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In recent years, use of newer antifungal therapies for invasive candidiasis has increased given the rise in infections with <jats:italic>non\u2010albicans<\/jats:italic> species of <jats:italic>Candida.<\/jats:italic> To identify current practices of the management of endogenous candida endophthalmitis and relevant antifungal drug research in this disease state, we conducted a MEDLINE search (1967\u20132006) and bibliographic search of the English\u2010language literature. Treatments for candida endophthalmitis have not been evaluated through well\u2010designed, well\u2010powered clinical trials. Data have mainly been presented in case reports, case series, animal studies, pharmacokinetic studies, and as small subsets of larger trials. Traditional systemic therapies have been amphotericin B with or without flucytosine or fluconazole. Cure rates with antifungal drugs alone appear to be much higher in patients with chorioretinitis than in endophthalmitis with vitreal involvement. Pars plana vitrectomy with or without intravitreal amphotericin B injections has been advocated particularly for patients with moderate\u2010to\u2010severe vitritis and substantial vision loss. Information on new antifungal agents for endophthalmitis is limited, despite increasing use in patients with candidemia. Voriconazole may be a particularly attractive agent to consider for infections with fluconazole\u2010resistant, voriconazole\u2010susceptible strains. The current patchwork of animal studies and small patient reports provide clinicians with some insight into the role of newer agents in the treatment of candida endophthalmitis. In general, it appears that chorioretinitis infections can be more readily cured with most systemic antifungal agents, whereas more aggressive treatment, often including vitrectomy with or without intravitreal antifungal administration, is needed for patients with endophthalmitis with vitritis.<\/jats:p>","DOI":"10.1592\/phco.27.12.1711","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:17:38Z","timestamp":1196155058000},"page":"1711-1721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Candida Endophthalmitis: Focus on Current and Future Antifungal Treatment Options"],"prefix":"10.1002","volume":"27","author":[{"given":"Fida 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