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Therapy is directed primarily at resolving the symptoms of microscopic colitis; bismuth subsalicylate, aminosalicylates, traditional corticosteroids, and budesonide have been evaluated. Compared with other therapies, budesonide has the strongest evidence for effectiveness in decreasing the volume and frequency of stools and improving the quality of life; it is, however, a costly drug. We reviewed all available primary English\u2010language literature accounts of treatment of microscopic colitis. We performed searches of MEDLINE and International Pharmaceutical Abstracts, as well as reviewing the bibliographies from key articles, to procure pertinent reports. Microscopic colitis can be successfully treated with pharmacotherapy. Based on cost and adverse\u2010effect profiles, antidiarrheals and bismuth subsalicylate are reasonable first options, but many patients may require budesonide to achieve remission.<\/jats:p>","DOI":"10.1592\/phco.27.3.425","type":"journal-article","created":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T11:21:56Z","timestamp":1172229716000},"page":"425-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacotherapy for Microscopic Colitis"],"prefix":"10.1002","volume":"27","author":[{"given":"Geoffrey C.","family":"Wall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori L.","family":"Schirmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Page","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.4065\/78.5.614"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i35.5535"},{"key":"e_1_2_1_4_2","first-page":"87","article-title":"Collagenous colitis with watery diarrhea: a new entity?","volume":"11","author":"Lindstrom CG","year":"1976","journal-title":"Pathol Eur"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90575-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.014431"},{"issue":"2","key":"e_1_2_1_7_2","first-page":"A124","article-title":"The epidemiology of microscopic colitis: a population\u2010based study in Olmstead County, Minnesota [abstract]","volume":"126","author":"Pardi DS","year":"2004","journal-title":"Gastroenterology"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91030-L"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05595.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1155\/2003\/404857","article-title":"Lymphocytic and collagenous colitis: the emerging entity of microscopic colitis. 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