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Clopidogrel has been shown to prevent stent thrombosis in patients undergoing percutaneous coronary intervention (PCI) and reduces major adverse cardiovascular events in patients with unstable angina or non\u2013ST\u2010segment elevation myocardial infarction (non\u2010STEMI). Recent studies have left clinicians with many questions regarding the role and dosing regimens of clopidgrel in STEMI, PCI, and primary or secondary prevention. Based on an analysis of the data, clopidogrel should be given in addition to aspirin and fibrinolytic therapy to patients with STEMI. In patients undergoing PCI, a loading dose of clopidogrel 600 mg should be given if the procedure needs to be performed within 15 hours of initial presentation. If PCI can be delayed for 15 hours or more, a loading dose of 300 mg can be used. Evidence also suggests that clopidogrel should not be prescribed for primary prevention in high\u2010risk patients.<\/jats:p>","DOI":"10.1592\/phco.27.4.553","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T08:47:38Z","timestamp":1174898858000},"page":"553-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Contemporary Issues in Clopidogrel Therapy: New Evidence Shaping Clinical Practice"],"prefix":"10.1002","volume":"27","author":[{"given":"Kristi L.","family":"Emmons","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-5-199809010-00009"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.15.1667"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.19.2411"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010746"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09457-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05701-4"},{"key":"e_1_2_1_8_2","unstructured":"BraunwaldE AntmanEM BeasleyJW et al.ACC\/AHA 2002 guideline update for the management of patients with unstable angina and non\u2014ST\u2010segment elevation myocardial infarction: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines (committee on the management of patients with unstable angina) 2002. 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