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The species were generally regarded as nonpathogenic and of little importance in clinical microbiology until several occurrences of <jats:italic>Leuconostoc<\/jats:italic> infections were reported in the literature. Unlike many gram\u2010positive bacteria, <jats:italic>Leuconostoc<\/jats:italic> species commonly demonstrate high\u2010level resistance to vancomycin, with preserved sensitivity to most other antibacterial agents. We describe a 55\u2010year\u2010old man who developed endocarditis caused by <jats:italic>Leuconostoc<\/jats:italic> species sensitive to vancomycin. 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