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Methemoglobinemia develops in the presence of oxidizing agents, such as benzocaine\u2010containing topical anesthetic sprays, and it is characterized by cyanosis. If untreated, methemoglobinemia may prove lethal. We describe two patients who developed methemoglobinemia after they were administered benzocaine\u2010containing topical anesthetic sprays. Using the Naranjo adverse drug reaction probability scale, the relationship between the administration of the benzocaine\u2010containing spray and the development of methemoglobinemia was probable (score of 7) in both patients. Collaboration among health care providers is necessary to efficiently recognize, treat, and manage this condition.<\/jats:p>","DOI":"10.1592\/phco.27.8.1206","type":"journal-article","created":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T09:57:57Z","timestamp":1185530277000},"page":"1206-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Benzocaine\u2010Induced Methemoglobinemia in Two Patients: Interdisciplinary Collaboration, Management, and Near Misses"],"prefix":"10.1002","volume":"27","author":[{"given":"Melinda J.","family":"Throm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margie Dale","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"U.S. Food and Drug Administration.Anesthetic sprays and methemoglobinemia. 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