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However, to our knowledge, no case of rosuvastatin\u2010induced gynecomastia has been reported in the literature. We describe a 57\u2010year\u2010old man who developed bilateral gynecomastia after 2 months of rosuvastatin therapy. After switching to a different statin, atorvastatin, his symptoms resolved within 1 month. Use of the Naranjo adverse drug reaction probability scale indicated a possible relationship between the patient's development of gynecomastia and rosuvastatin therapy. The relatively strong effect of rosuvastatin on inhibiting steroidogenesis might have explained why our patient's gynecomastia occurred only with this agent. Clinicians should be aware of the possibility of adverse endocrine reactions when statins are prescribed, including newer agents such as rosuvastatin.<\/jats:p>","DOI":"10.1592\/phco.28.4.549","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T07:19:51Z","timestamp":1206515991000},"page":"549-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Gynecomastia Possibly Induced by Rosuvastatin"],"prefix":"10.1002","volume":"28","author":[{"given":"Alessandro","family":"Oteri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonietta","family":"Catania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Travaglini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saffi E.","family":"Giustini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille P.","family":"Caputi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Polimeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198010023031405"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp070677"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-42-10812P"},{"key":"e_1_2_1_5_2","first-page":"636","article-title":"Some recent advances in virilizing and feminizing syndromes and hirsutism","volume":"41","author":"Gabrilove JL","year":"1974","journal-title":"Mt Sinai J Med"},{"key":"e_1_2_1_6_2","first-page":"47","article-title":"Gynaecomastia","volume":"31","author":"Smals AG","year":"1987","journal-title":"Neth J Med"},{"key":"e_1_2_1_7_2","unstructured":"AlleeMR.Gynecomastia. 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