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Usually they shorten the duration of menses, decrease the frequency of menses to 4 times\/year, or completely eliminate menses. These new oral contraceptives are given in the following regimens: 24 days followed by placebo for 4 days (24\/4), 84 days followed by placebo for 7 days (84\/7), or continuously (without placebo). These agents contain ethinyl estradiol 20 \u03bcg\u2010drospirenone 3 mg (24\/4); ethinyl estradiol 20 \u03bcg\u2010norethindrone 1 mg (24\/4); ethinyl estradiol 30 \u03bcg\u2010levonorgestrel 150 \u03bcg (84\/7); ethinyl estradiol 30 \u03bcg\u2010levonorgestrel 150 \u03bcg (84\/7) with very low\u2010dose ethinyl estradiol (10 \u03bcg\/day) for 7 days; and ethinyl estradiol 20 \u03bcg\u2010levonorgestrel 90 \u03bcg continuously. Clinical trials have demonstrated that extended\u2010 and continuous\u2010cycle oral contraceptives are as effective in preventing pregnancy as traditional oral contraceptives. These new agents also have similar adverse effects; however, the only significantly different adverse effect compared with traditional oral contraceptives in clinical trials was change in bleeding pattern. These oral contraceptives are associated with more breakthrough bleeding and spotting than the traditional pills. Long\u2010term effects on efficacy and safety are not known, as these new products generally have been used for only 1\u20132 years. Extended\u2010 and continuous\u2010cycle oral contraceptives are a new option for women desiring decreased menses or for whom decreased menses may alleviate symptoms of coexisting medical conditions.<\/jats:p>","DOI":"10.1592\/phco.28.8.1033","type":"journal-article","created":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T12:56:02Z","timestamp":1216990562000},"page":"1033-1040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Extended\u2010 and Continuous\u2010Cycle Oral Contraceptives"],"prefix":"10.1002","volume":"28","author":[{"given":"Sarah P.","family":"Shrader","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori M.","family":"Dickerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"S1","article-title":"Canadian consensus guideline on continuous and extended hormonal contraception, 2007. 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