{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:45:32Z","timestamp":1761662732179,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":1041,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>A 75\u2010year\u2010old woman with diabetes mellitus, hypertension, and hyperlipidemia came to the emergency department with generalized and upper\u2010extremity weakness; she had experienced a fall 2 months earlier. On admission, her drug therapy included lovastatin 40 mg\/day, controlled\u2010release diltiazem 240 mg\/day, and glimepiride 1 mg\/day. Nineteen days earlier, sitagliptin 100 mg\/day had been started; it was discontinued 2 weeks later, and glimepiride was begun. A cardiology consultation performed on the day of admission determined that a markedly elevated creatine kinase\u2010myocardial band isoenzyme level and borderline\u2010high troponin I level were diagnostic of rhabdomyolysis secondary to statin use. Because the patient had been taking lovastatin for the past 12 years, the possibility that the rhabdomyolysis may have been caused by a drug interaction between lovastatin and a concomitant drug was evaluated. As it had been 10 months since her last dosage adjustment of diltiazem, it was unlikely that the statin\u2010induced rhabdomyolysis was precipitated by diltiazem. Use of the Drug Interaction Probability Scale to determine the strength of a lovastatin\u2010sitagliptin interaction indicated a possible association (score of 4). Multiple drug interactions have been reported with lovastatin. To our knowledge, however, this is the first case report of a possible sitagliptin\u2010lovastatin interaction that may have caused rhabdomyolysis. Studies must be performed to further evaluate the in vivo effect of sitagliptin on the cytochrome P450 3A4 enzyme system and to elucidate other mechanisms that may potentiate such a drug\u2010drug interaction. In the meantime, however, clinicians should be aware of this possible drug interaction.<\/jats:p>","DOI":"10.1592\/phco.29.3.352","type":"journal-article","created":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T09:55:55Z","timestamp":1235728555000},"page":"352-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Rhabdomyolysis Caused by a Potential Sitagliptin\u2010Lovastatin Interaction"],"prefix":"10.1002","volume":"29","author":[{"given":"Robert V.","family":"DiGregorio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanina","family":"Pasikhova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e318123f771"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-S004"},{"key":"e_1_2_1_4_2","unstructured":"National Cholesterol Education Program National Heart Lung and Blood Institute National Institutes of Health. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection evaluation and treatment of high blood cholesterol in adults (adult treatment panel III): final report. NIH publication no. 02\u20135215. September 2002. Available fromwww.nhlbi.nih.govguidelinescholesterolatp3full.pdf. AccessedNovember 10 2007."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2245"},{"volume-title":"Januvia (sitagliptin) package insert","year":"2007","author":"Merck & Co., Inc","key":"e_1_2_1_6_2"},{"volume-title":"Mevacor (lovastatin) package insert","year":"2007","author":"Merck & Co., Inc","key":"e_1_2_1_7_2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.09.003"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10228"},{"issue":"6","key":"e_1_2_1_10_2","article-title":"Rhabdomyolysis: diagnosis and treatment [online exclusive article]","volume":"56","author":"Jois\u2010Bilowich P","year":"2007","journal-title":"Resident Staff Physician"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3810\/psm.2004.04.197"},{"issue":"7","key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1093\/ajhp\/60.7.698","article-title":"High\u2010dose simvastatin and rhabdomyolysis","volume":"60","author":"Wratchford P","year":"2003","journal-title":"Am J Health Syst Pharm"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H423"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-8-200404200-00037-w1"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199510000-00040"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.50.221"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh745"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.07.233"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2006.03.022"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.22.2671"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.29.3.352","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.29.3.352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:45:30Z","timestamp":1761065130000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.29.3.352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1592\/phco.29.3.352"],"URL":"https:\/\/doi.org\/10.1592\/phco.29.3.352","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"2012-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}