{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:25:58Z","timestamp":1761708358280,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":949,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p><jats:bold>Study Objective.<\/jats:bold> To determine the effects of hawthorn (<jats:italic>Crataegus oxycantha<\/jats:italic>) on left ventricular remodeling and function in pressure overload\u2010induced heart failure in an animal model.<\/jats:p><jats:p><jats:bold>Design.<\/jats:bold> Randomized, parallel, dose\u2010ranging animal study.<\/jats:p><jats:p><jats:bold>Setting.<\/jats:bold> University research facility.<\/jats:p><jats:p><jats:bold>Animals.<\/jats:bold> Seventy\u2010four male Sprague\u2010Dawley rats; 44 were included in the final analysis.<\/jats:p><jats:p><jats:bold>Intervention.<\/jats:bold> Rats underwent a sham operation or aortic constriction. Rats subjected to the sham operation were treated with vehicle (10% agar\u2010agar), and those subjected to aortic constriction were treated with vehicle or hawthorn (<jats:italic>C. oxycantha<\/jats:italic> special extract WS 1442) 1.3, 13, or 130 mg\/kg for 5 months.<\/jats:p><jats:p><jats:bold>Measurements and Main Results.<\/jats:bold> Rats and their hearts were weighed, and echocardiographic measurements were performed at baseline and at 2, 3, 4, and 5 months after aortic constriction. Protein expression for markers of fibrosis and for atrial natriuretic factor was also measured. Aortic constriction increased the left ventricular:body weight ratio by 53% in vehicle\u2010treated rats; Hawthorn treatment did not significantly affect the aortic constriction\u2010induced increase in this ratio. Left ventricular volumes and dimensions at systole and diastole significantly increased 5 months after aortic constriction compared with baseline in rats given vehicle (&gt; 20% increase, p&lt;0.05) but not in those given hawthorn 130 mg\/kg (&lt; 10% increase). After aortic constriction, the velocity of circumferential shortening significantly decreased in the vehicle group but not in the medium\u2010 or high\u2010dose groups. In the aortic constriction\u2010vehicle group, the induced increases in messenger RNA expression for atrial natriuretic factor (\u223c1000%) and fibronectin (\u223c80%) were significantly attenuated by highdose hawthorn treatment by approximately 80% and 50%, respectively.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold> Hawthorn treatment exhibited modest beneficial effects on cardiac remodeling and function during long\u2010term, pressure overload\u2010induced heart failure in rats.<\/jats:p>","DOI":"10.1592\/phco.29.6.639","type":"journal-article","created":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T22:02:24Z","timestamp":1243548144000},"page":"639-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Hawthorn on the Progression of Heart Failure in a Rat Model of Aortic Constriction"],"prefix":"10.1002","volume":"29","author":[{"given":"Hyun Seok","family":"Hwang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin O.","family":"Boluyt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimber","family":"Converso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry E.","family":"Bleske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021498"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000211745.70831.75"},{"key":"e_1_2_1_4_2","first-page":"H643","article-title":"Cardiac adaptations to aortic constriction in adult and aged rats","volume":"257","author":"Boluyt M.O.","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.3.1410"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1992.262.6.H1861"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020689.12472.E0"},{"key":"e_1_2_1_8_2","unstructured":"National Center for Complementary and Alternative Medicine National Institutes of Health.The use of complementary and alternative medicine in the United States. 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Presented at the 8th annual scientific meeting of the Heart Failure Society of America Toronto Ontario Canada September 1215 2004."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2008.10.004"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-008-6082-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01026.2003"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.75.1.23"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200005000-00004"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00476-7"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.09.050"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-9218-3"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959493"},{"key":"e_1_2_1_21_2","first-page":"191","article-title":"Phenolic constituents and antioxidant capacities of Crataegus monogyna (hawthorn) callus extracts","volume":"47","author":"Bahourn T.","year":"2003","journal-title":"Food"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(00)00137-6"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0620719"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000198029.22472.d9"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00608-1"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.11.014"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000070101.70534.38"},{"key":"e_1_2_1_28_2","first-page":"H1003","article-title":"Age\u2010associated increase in rat ventricular ANP gene expression correlates with cardiac hypertrophy","volume":"269","author":"Younes A.","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-9248-x"},{"issue":"3","key":"e_1_2_1_30_2","first-page":"25","article-title":"Myocardial fibrosis: role of ventricular systolic pressure, arterial hypertension, and circulating hormones","volume":"86","author":"Weber K.T.","year":"1991","journal-title":"Basic Res Cardiol"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1592%2Fphco.29.6.639","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1592\/phco.29.6.639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:08:15Z","timestamp":1761062895000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1592\/phco.29.6.639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1592\/phco.29.6.639"],"URL":"https:\/\/doi.org\/10.1592\/phco.29.6.639","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"2012-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}