{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:54:32Z","timestamp":1782431672628,"version":"3.54.5"},"reference-count":67,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":888,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>Venous thromboembolism, a condition that includes deep vein thrombosis and pulmonary embolism, is a significant medical problem that affects more than 1 million patients each year. In addition to the immense impact of venous thromboembolism on morbidity and mortality, the economic burden of the disease is considerable, costing the health care system in the United States more than $1.5 billion\/year. The cost of managing an initial episode of deep vein thrombosis is estimated at $7712\u201010,804, and for an initial pulmonary embolism event $9566\u201016,644. Management of acute venous thromboembolism in patients with cancer costs more than $20,000. Although much of the costs of venous thromboembolism are associated with managing the acute event, there are also significant costs associated with its long\u2010term complications such as recurrent venous thromboembolism, post\u2010thrombotic syndrome, and pulmonary hypertension. Data from numerous robust clinical trials have demonstrated that with appropriate prophylaxis, many of these venous thromboembolism events can be prevented in both surgical and medical patients. Even though the strong evidence supporting venous thromboembolism prophylaxis spans several decades, a number of large American and global registries have documented very poor use of appropriate venous thromboprophylaxis. Because of increasing regulatory requirements, hospitals nationwide are developing necessary documentation of appropriate venous thromboembolism prophylaxis programs for both surgical and medical patients. Hospitals and clinicians must have a firm understanding of not only the clinical impact but also the economic impact of failing to use appropriate prophylaxis and of the cost\u2010effectiveness of different venous thromboprophylaxis methods.<\/jats:p>","DOI":"10.1592\/phco.29.8.943","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T10:17:45Z","timestamp":1248776265000},"page":"943-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Economic Burden of Venous Thromboembolism in Hospitalized Patients"],"prefix":"10.1002","volume":"29","author":[{"given":"Paul P.","family":"Dobesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0656"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.22.17.1564.34124"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(75)80017-X"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400050081016"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1182\/blood.V106.11.910.910","article-title":"Estimated annual number of incident and recurrent, non\u2010fatal and fatal venous thromboembolism (VTE) events in the U.S","volume":"106","author":"Heit JA","year":"2005","journal-title":"[abstract] Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.1.108"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20983"},{"issue":"23","key":"e_1_2_1_9_2","first-page":"I4","article-title":"The epidemiology of venous thromboembolism","volume":"107","author":"White RH","year":"2003","journal-title":"Circulation"},{"key":"e_1_2_1_10_2","first-page":"101","article-title":"Prevention and treatment of venous thromboembolism: international consensus statement (guidelines according to scientific evidence)","volume":"25","author":"Cardiovascular Disease Educational and Research Trust; Cyprus Cardiovascular Disease Educational and Research Trust; European Venous Forum; International Surgical Thrombosis Forum; International Union of Angiology; Union Internationale de Phl\u00e9bologie","year":"2006","journal-title":"Int Angiol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909093411103"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138928.83266.24"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38733.466748.7C"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060388"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.01.018"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2007.13.6.475"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.14.1471"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2993"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.6.761"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6778.709"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcp.0000239543.40078.17"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032274"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.81.2.151"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.6.809"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060389"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.9.963"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.09.057"},{"key":"e_1_2_1_28_2","unstructured":"The Joint Commission.National consensus standards for prevention and care of venous thromboembolism (VTE). 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