{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:35:27Z","timestamp":1760985327319},"reference-count":58,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":2103,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1593\/neo.08402","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T13:06:15Z","timestamp":1429794375000},"page":"817-IN15","source":"Crossref","is-referenced-by-count":21,"title":["Generation and Characterization of Novel Local and Metastatic Human Neuroblastoma Variants"],"prefix":"10.1016","volume":"10","author":[{"given":"Ido","family":"Nevo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit","family":"Sagi-Assif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat Edry","family":"Botzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Amar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelly","family":"Maman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naam","family":"Kariv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor E.","family":"Leider-Trejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Savelyeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilana","family":"Yron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac P.","family":"Witz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1593\/neo.08402_bib1","unstructured":"National Cancer Institute, Surveillance, Epidemiology, and End Results Database. Available at: http:\/\/seer.cancer.gov. Accessed July 2007."},{"key":"10.1593\/neo.08402_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00268-004-7820-7","article-title":"Gene profiling of high risk neuroblastoma","volume":"29","author":"Vasudevan","year":"2005","journal-title":"World J Surg"},{"key":"10.1593\/neo.08402_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrc1014","article-title":"Neuroblastoma: biological insights into a clinical enigma","volume":"3","author":"Brodeur","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1593\/neo.08402_bib4","series-title":"Principles and Practice of Pediatric Oncology","first-page":"761","article-title":"Chapter 29. Neuroblastoma","author":"Brodeur","year":"1997"},{"key":"10.1593\/neo.08402_bib5","series-title":"Clinical Pediatric Oncology","first-page":"437","article-title":"Chapter 24: Neuroblastoma and other peripheral neuroectodermal tumors","author":"Brodeur","year":"1991"},{"key":"10.1593\/neo.08402_bib6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/(SICI)1096-911X(199706)28:6<429::AID-MPO7>3.0.CO;2-I","article-title":"Lung involvement in neuroblas-toma: incidence and characteristics","volume":"28","author":"Cowie","year":"1997","journal-title":"Med Pediatr Oncol"},{"key":"10.1593\/neo.08402_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2214\/ajr.138.1.75","article-title":"Pulmonary metastases in neuroblastoma","volume":"138","author":"Towbin","year":"1982","journal-title":"AJR Am J Roentgenol"},{"key":"10.1593\/neo.08402_bib8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2214\/ajr.176.3.1760755","article-title":"Pulmonary metastases at diagnosis of neuroblastoma in pediatric patients: CT findings and prognosis","volume":"176","author":"Kammen","year":"2001","journal-title":"AJR Am J Roentgenol"},{"key":"10.1593\/neo.08402_bib9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer metastasis: building a framework","volume":"127","author":"Gupta","year":"2006","journal-title":"Cell"},{"key":"10.1593\/neo.08402_bib10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10555-006-9028-9","article-title":"Mechanisms of invasion and metastasis in human neuroblastoma","volume":"25","author":"Ara","year":"2006","journal-title":"Cancer Metastasis Rev"},{"key":"10.1593\/neo.08402_bib11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrc1098","article-title":"The pathogenesis of cancer metastasis: the \u201cseed and soil\u201d hypothesis revisited","volume":"3","author":"Fidler","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1593\/neo.08402_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/0008-5472.CAN-07-2917","article-title":"Yin-yang activities and vicious cycles in the tumor microenvironment","volume":"68","author":"Witz","year":"2008","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/ijc.1210","article-title":"Murine models for experimental therapy of pediatric solid tumors with poor prognosis","volume":"92","author":"Beltinger","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1593\/neo.08402_bib14","first-page":"77","article-title":"Biologically relevant orthotopic neuroblastoma xenograft models: primary adrenal tumor growth and spontaneous distant metastasis","volume":"16","author":"Khanna","year":"2002","journal-title":"In Vivo"},{"key":"10.1593\/neo.08402_bib15","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10585-004-4091-5","article-title":"A fluorescent orthotopic mouse model for reliable measurement and genetic modulation of human neuroblastoma metastasis","volume":"21","author":"Henriksson","year":"2004","journal-title":"Clin Exp Metastasis"},{"key":"10.1593\/neo.08402_bib16","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1002\/(SICI)1097-0142(19970501)79:9<1757::AID-CNCR18>3.0.CO;2-X","article-title":"A comparative review of the immunobiology of murine neuroblastoma and human neuroblastoma","volume":"79","author":"Ziegler","year":"1997","journal-title":"Cancer"},{"key":"10.1593\/neo.08402_bib17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/(SICI)1097-0215(19960729)67:3<379::AID-IJC12>3.0.CO;2-3","article-title":"A metastatic neuroblastoma model in SCID mice","volume":"67","author":"Bogenmann","year":"1996","journal-title":"Int J Cancer"},{"key":"10.1593\/neo.08402_bib18","first-page":"1943","article-title":"In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice","volume":"48","author":"Morikawa","year":"1988","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib19","first-page":"5532","article-title":"Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice","volume":"9","author":"Onn","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1593\/neo.08402_bib20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/sj.neo.7900005","article-title":"In vivo selection and characterization of metastatic variants from human pancreatic adenocar-cinoma by using orthotopic implantation in nude mice","volume":"1","author":"Bruns","year":"1999","journal-title":"Neoplasia"},{"key":"10.1593\/neo.08402_bib21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1368-8375(98)80003-1","article-title":"Isolation of a highly metastatic cell line to lymph node in human oral squamous cell carcinoma by orthotopic implantation in nude mice","volume":"34","author":"Matsui","year":"1998","journal-title":"Oral Oncol"},{"key":"10.1593\/neo.08402_bib22","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s00432-004-0564-9","article-title":"Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics","volume":"130","author":"Li","year":"2004","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1593\/neo.08402_bib23","first-page":"3751","article-title":"Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones","volume":"38","author":"Biedler","year":"1978","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib24","first-page":"1329","article-title":"Characterization of a continuous cell line (MHH-NB-11) derived from advanced neuroblastoma","volume":"8","author":"Pietsch","year":"1988","journal-title":"Anticancer Res"},{"key":"10.1593\/neo.08402_bib25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4049\/jimmunol.123.1.342","article-title":"Use of a monoclonal antibody (W6\/32) in structural studies of HLA-A,B,C, antigens","volume":"123","author":"Parham","year":"1979","journal-title":"J Immunol"},{"key":"10.1593\/neo.08402_bib26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4049\/jimmunol.126.1.317","article-title":"Monoclonal antibodies to mouse MHC antigens: III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression","volume":"126","author":"Ozato","year":"1981","journal-title":"J Immunol"},{"key":"10.1593\/neo.08402_bib27","first-page":"2383","article-title":"Differential tumorigenicity of 3T3 cells transformed in vitro with polyoma virus and in vivo selection for high tumorigenicity","volume":"49","author":"Halachmi","year":"1989","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib28","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/cyto.10159","article-title":"Flow cytometric immunophenotyping test for staging\/monitoring neuroblastoma patients","volume":"50","author":"Warzynski","year":"2002","journal-title":"Cytometry"},{"key":"10.1593\/neo.08402_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cyto.2004.10.003","article-title":"Cellular characteristics of neuroblas-toma cells: regulation by the ELR-CXC chemokine CXCL10 and expression of a CXCR3-like receptor","volume":"29","author":"Goldberg-Bittman","year":"2005","journal-title":"Cytokine"},{"key":"10.1593\/neo.08402_bib30","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/0959-8049(95)00055-N","article-title":"Antiproliferative potential of cytostatic drugs on neuroblastoma cells in vitro","volume":"31A","author":"Fulda","year":"1995","journal-title":"Eur J Cancer"},{"key":"10.1593\/neo.08402_bib31","first-page":"1749","article-title":"Antineuroblastoma activity of desferoxamine in human cell lines","volume":"47","author":"Blatt","year":"1987","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib32","first-page":"7189","article-title":"Deferoxamine inhibition of human neuroblas-toma viability and proliferation","volume":"48","author":"Becton","year":"1988","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib33","first-page":"2347","article-title":"D-CECaT as preoperative chemotherapy for unresectable neuroblastoma in children over one year of age","volume":"15","author":"Donfrancesco","year":"1995","journal-title":"Anticancer Res"},{"key":"10.1593\/neo.08402_bib34","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/0959-8049(95)00068-T","article-title":"Deferoxamine followed by cyclophos-phamide, etoposide, carboplatin, thiotepa, induction regimen in advanced neu-roblastoma: preliminary results. Italian Neuroblastoma Cooperative Group","volume":"31A","author":"Donfrancesco","year":"1995","journal-title":"Eur J Cancer"},{"key":"10.1593\/neo.08402_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10555-006-7886-9","article-title":"Matrix metalloproteinases and tumor metastasis","volume":"25","author":"Deryugina","year":"2006","journal-title":"Cancer Metastasis Rev"},{"key":"10.1593\/neo.08402_bib36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrc1821","article-title":"Tumour microenvironment\u2014opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy","volume":"6","author":"Overall","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1593\/neo.08402_bib37","first-page":"E73","article-title":"The role of the hypoxia-inducible factor in tumor metabolism growth and invasion","volume":"93","author":"Brahimi-Horn","year":"2006","journal-title":"Bull Cancer"},{"key":"10.1593\/neo.08402_bib38","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1023\/A:1022939318102","article-title":"The hypoxic tumour microenvironment and metastatic progression","volume":"20","author":"Subarsky","year":"2003","journal-title":"Clin Exp Metastasis"},{"key":"10.1593\/neo.08402_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.critrevonc.2005.12.003","article-title":"Regulation of angiogenesis by hypoxia-inducible factor 1","volume":"59","author":"Hirota","year":"2006","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1593\/neo.08402_bib40","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature03799","article-title":"Genes that mediate breast cancer metastasis to lung","volume":"436","author":"Minn","year":"2005","journal-title":"Nature"},{"key":"10.1593\/neo.08402_bib41","series-title":"Neuroblastoma","author":"Cheung","year":"2005"},{"key":"10.1593\/neo.08402_bib42","first-page":"449","article-title":"Human neuroblastoma I-type cells are malignant neural crest stem cells","volume":"6","author":"Ross","year":"1995","journal-title":"Cell Growth Differ"},{"key":"10.1593\/neo.08402_bib43","first-page":"1383","article-title":"Coordinate changes in neuronal phenotype and surface antigen expression in human neu-roblastoma cell variants","volume":"47","author":"Rettig","year":"1987","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib44","first-page":"5396","article-title":"Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy","volume":"58","author":"Keshelava","year":"1998","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib45","first-page":"2643","article-title":"Morphology and growth, tumor-igenicity, and cytogenetics of human neuroblastoma cells in continuous culture","volume":"33","author":"Biedler","year":"1973","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib46","first-page":"3058","article-title":"Differences in drug sensitivity among tumor cells from parental tumors, selected variants, and spontaneous metastases","volume":"41","author":"Tsuruo","year":"1981","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib47","first-page":"959","article-title":"Differential drug sensitivity of human neuroblastoma cells","volume":"70","author":"Spengler","year":"1986","journal-title":"Cancer Treat Rep"},{"key":"10.1593\/neo.08402_bib48","first-page":"37","article-title":"Gelatinase-mediated migration and invasion of cancer cells","volume":"1755","author":"Bjorklund","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1593\/neo.08402_bib49","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0024-3205(00)01030-4","article-title":"Angiogenesis extent and expression of matrix me-talloproteinase-2 and -9 correlate with progression in human neuroblastoma","volume":"68","author":"Ribatti","year":"2001","journal-title":"Life Sci"},{"key":"10.1593\/neo.08402_bib50","first-page":"2209","article-title":"Matrix metalloproteinases-2 and -9 are expressed in human neuroblastoma: contribution of stromal cells to their production and correlation with metastasis","volume":"58","author":"Sugiura","year":"1998","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib51","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nrc1949","article-title":"Cysteine cathepsins: multifunctional enzymes in cancer","volume":"6","author":"Mohamed","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1593\/neo.08402_bib52","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.4049\/jimmunol.167.8.4747","article-title":"A possible role for CXCR4 and its ligand, the CXC che-mokine stromal cell-derived factor-1, in the development of bone marrow me-tastases in neuroblastoma","volume":"167","author":"Geminder","year":"2001","journal-title":"J Immunol"},{"key":"10.1593\/neo.08402_bib53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.imlet.2003.10.019","article-title":"The tumor microenvironment: CXCR4 is associated with distinct protein expression patterns in neuroblastoma cells","volume":"92","author":"Nevo","year":"2004","journal-title":"Immunol Lett"},{"key":"10.1593\/neo.08402_bib54","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1158\/0008-5472.CAN-05-1631","article-title":"Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells","volume":"66","author":"Holland","year":"2006","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08402_bib55","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.imbio.2005.12.003","article-title":"Differences in CXCR4-mediated signaling in B cells","volume":"211","author":"Palmesino","year":"2006","journal-title":"Immunobiology"},{"key":"10.1593\/neo.08402_bib56","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1182\/blood.V82.12.3610.3610","article-title":"Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction","volume":"82","author":"Wang","year":"1993","journal-title":"Blood"},{"key":"10.1593\/neo.08402_bib57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10585-007-9057-y","article-title":"Involvement of Hif-1 in desferrioxamine-induced invasion of glioblastoma cells","volume":"24","author":"Elstner","year":"2007","journal-title":"Clin Exp Metastasis"},{"key":"10.1593\/neo.08402_bib58","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10555-007-9062-2","article-title":"Hypoxia-driven selection of the metastatic phenotype","volume":"26","author":"Sullivan","year":"2007","journal-title":"Cancer Metastasis Rev"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558608800358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558608800358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T18:51:50Z","timestamp":1691607110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558608800358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S1476558608800358"],"URL":"https:\/\/doi.org\/10.1593\/neo.08402","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}