{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:05:05Z","timestamp":1791309905703,"version":"4.3.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":1919,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1593\/neo.08980","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T12:59:53Z","timestamp":1429793993000},"page":"167-IN9","source":"Crossref","is-referenced-by-count":121,"title":["Hodgkin Lymphoma Cell Lines Are Characterized by a Specific miRNA Expression Profile"],"prefix":"10.1016","volume":"11","author":[{"given":"Johan H.","family":"Gibcus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu Ping","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Harms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikst Nynke","family":"Schakel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tjasso","family":"Blokzijl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibrand","family":"Poppema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart-Jan","family":"Kroesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1593\/neo.08980_bib1","first-page":"159","article-title":"Hodgkin's disease: classification and differential diagnosis","volume":"12","author":"Harris","year":"1999","journal-title":"Mod Pathol"},{"key":"10.1593\/neo.08980_bib2","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1182\/blood-2002-03-0839","article-title":"Loss of the B-lineage-specific gene expression program in Hodgkin and Reed Sternberg cells of Hodgkin lymphoma","volume":"101","author":"Schwering","year":"2003","journal-title":"Blood"},{"key":"10.1593\/neo.08980_bib3","first-page":"1644","article-title":"Typing the histogenetic origin of the tumor cells of lymphocyte rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocytepredominance Hodgkin's lymphoma","volume":"63","author":"Brauninger","year":"2003","journal-title":"Cancer Res"},{"key":"10.1593\/neo.08980_bib4","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1182\/blood-2003-06-1841","article-title":"The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma","volume":"102","author":"Savage","year":"2003","journal-title":"Blood"},{"key":"10.1593\/neo.08980_bib5","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1593\/neo.08980_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","article-title":"MicroRNA targeting specificity in mammals: determinants beyond seed pairing","volume":"27","author":"Grimson","year":"2007","journal-title":"Mol Cell"},{"key":"10.1593\/neo.08980_bib7","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"10.1593\/neo.08980_bib8","doi-asserted-by":"crossref","first-page":"7080","DOI":"10.1073\/pnas.0702409104","article-title":"miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely","volume":"104","author":"Zhou","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1593\/neo.08980_bib9","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1038\/sj.leu.2404387","article-title":"The role of microRNAs in normal hematopoiesis and hematopoietic malignancies","volume":"20","author":"Kluiver","year":"2006","journal-title":"Leukemia"},{"key":"10.1593\/neo.08980_bib10","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.1141229","article-title":"Regulation of the germinal center response by microRNA-155","volume":"316","author":"Thai","year":"2007","journal-title":"Science"},{"key":"10.1593\/neo.08980_bib11","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1073\/pnas.0500613102","article-title":"Accumulation of miR-155 and BIC RNA in human B cell lymphomas","volume":"102","author":"Eis","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1593\/neo.08980_bib12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/path.1825","article-title":"BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas","volume":"207","author":"Kluiver","year":"2005","journal-title":"J Pathol"},{"key":"10.1593\/neo.08980_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/gcc.20273","article-title":"Lack of BIC and microRNA miR-155 expression in primary cases of Burkitt lymphoma","volume":"45","author":"Kluiver","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1593\/neo.08980_bib14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.immuni.2008.03.015","article-title":"MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase","volume":"28","author":"Teng","year":"2008","journal-title":"Immunity"},{"key":"10.1593\/neo.08980_bib15","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1093\/nar\/gni178","article-title":"Real-time quantification of microRNAs by stem-loop RT-PCR","volume":"33","author":"Chen","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1593\/neo.08980_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1261\/rna.234507","article-title":"Direct and sensitive miRNA profiling from low-input total RNA","volume":"13","author":"Wang","year":"2007","journal-title":"RNA"},{"key":"10.1593\/neo.08980_bib17","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1182\/blood-2005-06-2342","article-title":"Transformation of BCRdeficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas","volume":"106","author":"Bechtel","year":"2005","journal-title":"Blood"},{"key":"10.1593\/neo.08980_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/bioinformatics\/18.1.207","article-title":"Genesis: cluster analysis of microarray data","volume":"18","author":"Sturn","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1593\/neo.08980_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0076-6879(07)27004-1","article-title":"Computational methods for microRNA target prediction","volume":"427","author":"Watanabe","year":"2007","journal-title":"Methods Enzymol"},{"key":"10.1593\/neo.08980_bib20","doi-asserted-by":"crossref","first-page":"18277","DOI":"10.1074\/jbc.M601496200","article-title":"MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts","volume":"281","author":"Martin","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1593\/neo.08980_bib21","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"10.1593\/neo.08980_bib22","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1111\/j.1349-7006.2007.00618.x","article-title":"Downregulation of microRNAs-143 and -145 in B-cell malignancies","volume":"98","author":"Akao","year":"2007","journal-title":"Cancer Sci"},{"key":"10.1593\/neo.08980_bib23","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1182\/blood-2006-12-062398","article-title":"Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia","volume":"109","author":"Fulci","year":"2007","journal-title":"Blood"},{"key":"10.1593\/neo.08980_bib24","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1182\/blood-2007-06-096784","article-title":"MicroRNA expression profiling in classical Hodgkin lymphoma","volume":"111","author":"Navarro","year":"2008","journal-title":"Blood"},{"key":"10.1593\/neo.08980_bib25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2353\/ajpath.2008.080009","article-title":"MicroRNA-mediated down-regulation of PRDM1\/Blimp-1 in Hodgkin\/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas","volume":"173","author":"Nie","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1593\/neo.08980_bib26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jmb.2004.03.065","article-title":"Molecular evolution of a microRNA cluster","volume":"339","author":"Tanzer","year":"2004","journal-title":"J Mol Biol"},{"key":"10.1593\/neo.08980_bib27","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nsmb1250","article-title":"The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a","volume":"14","author":"Guil","year":"2007","journal-title":"Nat Struct Mol Biol"},{"key":"10.1593\/neo.08980_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/hon.804","article-title":"Global correlation of genome and transcriptome changes in classical Hodgkin lymphoma","volume":"25","author":"Kluiver","year":"2007","journal-title":"Hematol Oncol"},{"key":"10.1593\/neo.08980_bib29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000112062","article-title":"U-HO1, a new cell line derived from a primary refractory classical Hodgkin lymphoma","volume":"119","author":"Mader","year":"2007","journal-title":"Cytogenet Genome Res"},{"key":"10.1593\/neo.08980_bib30","doi-asserted-by":"crossref","first-page":"13944","DOI":"10.1073\/pnas.0506654102","article-title":"miR-15 and miR-16 induce apoptosis by targeting BCL2","volume":"102","author":"Cimmino","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1593\/neo.08980_bib31","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1200\/JCO.2005.04.358","article-title":"Expression of bcl-2 in classical Hodgkin's lymphoma: an independent predictor of poor outcome","volume":"23","author":"Sup","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1593\/neo.08980_bib32","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1038\/sj.onc.1210083","article-title":"miR-21-mediated tumor growth","volume":"26","author":"Si","year":"2007","journal-title":"Oncogene"},{"key":"10.1593\/neo.08980_bib33","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cell.2007.07.021","article-title":"MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb","volume":"131","author":"Xiao","year":"2007","journal-title":"Cell"},{"key":"10.1593\/neo.08980_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/path.2333","article-title":"miRNA analysis in B-cell chronic lymphocytic leukaemia: proliferation centres characterized by low miR-150 and high BIC\/miR-155 expression","volume":"215","author":"Wang","year":"2008","journal-title":"J Pathol"},{"key":"10.1593\/neo.08980_bib35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/gcc.20264","article-title":"Increased expression of microRNA- 155 in Epstein-Barr virus transformed lymphoblastoid cell lines","volume":"45","author":"Jiang","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1593\/neo.08980_bib36","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nature05992","article-title":"A viral microRNA functions as an orthologue of cellular miR-155","volume":"450","author":"Gottwein","year":"2007","journal-title":"Nature"},{"key":"10.1593\/neo.08980_bib37","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.4049\/jimmunol.179.8.5082","article-title":"Modulation of miR-155 and miR- 125b levels following lipopolysaccharide\/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock","volume":"179","author":"Tili","year":"2007","journal-title":"J Immunol"},{"key":"10.1593\/neo.08980_bib38","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1128\/JVI.02380-07","article-title":"MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways","volume":"82","author":"Yin","year":"2008","journal-title":"J Virol"},{"key":"10.1593\/neo.08980_bib39","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2007.10.009","article-title":"microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells","volume":"27","author":"Vigorito","year":"2007","journal-title":"Immunity"},{"key":"10.1593\/neo.08980_bib40","doi-asserted-by":"crossref","first-page":"16170","DOI":"10.1073\/pnas.0703942104","article-title":"Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development","volume":"104","author":"Gironella","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1593\/neo.08980_bib41","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.4049\/jimmunol.177.4.2527","article-title":"Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1\/IKK epsilon","volume":"177","author":"Harris","year":"2006","journal-title":"J Immunol"},{"key":"10.1593\/neo.08980_bib42","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1182\/blood-2002-08-2577","article-title":"Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma","volume":"101","author":"Barth","year":"2003","journal-title":"Blood"},{"key":"10.1593\/neo.08980_bib43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.regpep.2006.01.007","article-title":"Angiotensin II type 1 receptor expression on human leukocyte subsets: a flow cytometric and RT-PCR study","volume":"134","author":"Rasini","year":"2006","journal-title":"Regul Pept"},{"key":"10.1593\/neo.08980_bib44","doi-asserted-by":"crossref","first-page":"24262","DOI":"10.1074\/jbc.M701050200","article-title":"The human angiotensin II type 1 receptor +1166 A\/C polymorphism attenuates microrna-155 binding","volume":"282","author":"Martin","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1593\/neo.08980_bib45","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.modgep.2006.03.004","article-title":"Teashirt 3 expression in the chick embryo reveals a remarkable association with tendon development","volume":"6","author":"Manfroid","year":"2006","journal-title":"Gene Expr Patterns"},{"key":"10.1593\/neo.08980_bib46","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.1073\/pnas.1031851100","article-title":"Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia","volume":"100","author":"Ray","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1593\/neo.08980_bib47","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2141.2005.05881.x","article-title":"Inhibition of the phosphatidylinositol-3 kinase\/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma","volume":"132","author":"Georgakis","year":"2006","journal-title":"Br J Haematol"},{"key":"10.1593\/neo.08980_bib48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0002-9440(10)62238-9","article-title":"Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas","volume":"166","author":"Atayar","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1593\/neo.08980_bib49","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/ijc.2910260605","article-title":"Two neoplastic cell lines with unique features derived from Hodgkin's disease","volume":"26","author":"Schaadt","year":"1980","journal-title":"Int J Cancer"},{"key":"10.1593\/neo.08980_bib50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0002-9440(10)62238-9","article-title":"Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas","volume":"166","author":"Atayar","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1593\/neo.08980_bib51","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1182\/blood.V87.8.3429.bloodjournal8783429","article-title":"Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin\/Reed-Sternberg cells of a Hodgkin's lymphoma patient","volume":"87","author":"Kanzler","year":"1996","journal-title":"Blood"},{"key":"10.1593\/neo.08980_bib52","first-page":"399","article-title":"Phenotypic and genotypic analysis of Hodgkin's disease derived cell lines: histopathological and clinical implications","volume":"4","author":"Diehl","year":"1985","journal-title":"Cancer Surv"},{"key":"10.1593\/neo.08980_bib53","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.humpath.2006.01.018","article-title":"BCL6 alternative breakpoint region break and homozygous deletion of 17q24 in the nodular lymphocyte predominance type of Hodgkin's lymphoma-derived cell line DEV","volume":"37","author":"Atayar","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1593\/neo.08980_bib54","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1182\/blood-2002-07-2215","article-title":"Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma","volume":"101","author":"Copie-Bergman","year":"2003","journal-title":"Blood"},{"key":"10.1593\/neo.08980_bib55","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"10.1593\/neo.08980_bib56","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/gcc.20273","article-title":"Lack of BIC and microRNA miR- 155 expression in primary cases of Burkitt lymphoma","volume":"45","author":"Kluiver","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1593\/neo.08980_bib57","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1182\/blood-2005-06-2342","article-title":"Transformation of BCRdeficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas","volume":"106","author":"Bechtel","year":"2005","journal-title":"Blood"},{"key":"10.1593\/neo.08980_bib58","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0008-8749(92)90028-N","article-title":"Effects of IL-4, IL-5, and IL-6 on growth and immunoglobulin production of Epstein-Barr virus-infected human B cells","volume":"143","author":"Bende","year":"1992","journal-title":"Cell Immunol"}],"updated-by":[{"DOI":"10.1016\/j.neo.2017.11.008","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000}}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558609800298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558609800298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T21:52:36Z","timestamp":1747950756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558609800298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S1476558609800298"],"URL":"https:\/\/doi.org\/10.1593\/neo.08980","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}