{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:03:22Z","timestamp":1779159802335,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":764,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1593\/neo.12444","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T13:07:58Z","timestamp":1429794478000},"page":"311-323","source":"Crossref","is-referenced-by-count":36,"title":["Statins Impair Glucose Uptake in Tumor Cells"],"prefix":"10.1016","volume":"14","author":[{"given":"Agata","family":"Malenda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Skrobanska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Issat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Winiarska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Bil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bozenna","family":"Oleszczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Sinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Firczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz M.","family":"Bujnicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Chlebowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam D.","family":"Staruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliza","family":"Glodkowska-Mrowka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Kunikowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek","family":"Krolicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek","family":"Szablewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Gaciong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Koziak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Jakobisiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Golab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominika A.","family":"Nowis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1593\/neo.12444_bib1","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1126\/science.1193494","article-title":"The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes","volume":"330","author":"Levine","year":"2010","journal-title":"Science"},{"key":"10.1593\/neo.12444_bib2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrc2981","article-title":"Regulation of cancer cell metabolism","volume":"11","author":"Cairns","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1593\/neo.12444_bib3","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1002\/ijc.23449","article-title":"Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia","volume":"122","author":"Busk","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1593\/neo.12444_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10863-007-9085-y","article-title":"Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?","volume":"39","author":"Gillies","year":"2007","journal-title":"J Bioenerg Biomembr"},{"key":"10.1593\/neo.12444_bib5","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/ijc.20057","article-title":"Expression of GLUT-1 glucose transfer, cellular proliferation activity and grade of tumor correlate with [F-18]-fluorodeoxyglucose uptake by positron emission tomography in epithelial tumors of the ovary","volume":"109","author":"Kurokawa","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1593\/neo.12444_bib6","first-page":"22","article-title":"18F-FDG uptake in squamous cell carcinoma of the cervix is correlated with glucose transporter 1 expression","volume":"45","author":"Yen","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1593\/neo.12444_bib7","first-page":"1337","article-title":"Expression of glucose transporters in human pancreatic tumors compared with increased FDG accumulation in PET study","volume":"38","author":"Higashi","year":"1997","journal-title":"J Nucl Med"},{"key":"10.1593\/neo.12444_bib8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/iub.315","article-title":"The protein family of glucose transport facilitators: it's not only about glucose after all","volume":"62","author":"Augustin","year":"2010","journal-title":"IUBMB Life"},{"key":"10.1593\/neo.12444_bib9","first-page":"141","article-title":"Metabolic genes in cancer: their roles in tumor progression and clinical implications","volume":"1805","author":"Furuta","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1593\/neo.12444_bib10","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1200\/JCO.2009.27.4662","article-title":"Biologic correlation of 2-[18F]-fluoro-2-deoxy-d-glucose uptake on positron emission tomography in thymic epithelial tumors","volume":"28","author":"Kaira","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1593\/neo.12444_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1200\/JCO.20.2.379","article-title":"Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography","volume":"20","author":"Bos","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1593\/neo.12444_bib12","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1200\/JCO.2008.18.8383","article-title":"[18F]fluorodeoxyglucose positron emission tomography correlates with Akt pathway activity but is not predictive of clinical outcome during mTOR inhibitor therapy","volume":"27","author":"Ma","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1593\/neo.12444_bib13","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1371\/journal.pmed.0050064","article-title":"Statins impair antitumor effects of rituximab by inducing conformational changes of CD20","volume":"5","author":"Winiarska","year":"2008","journal-title":"PLoS Med"},{"key":"10.1593\/neo.12444_bib14","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nm0396-326","article-title":"HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: lovastatin specifically targets P-glycoprotein-expressing cells","volume":"2","author":"Dimitroulakos","year":"1996","journal-title":"Nat Med"},{"key":"10.1593\/neo.12444_bib15","doi-asserted-by":"crossref","first-page":"32770","DOI":"10.1074\/jbc.M110.148940","article-title":"Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors","volume":"285","author":"Allsopp","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1593\/neo.12444_bib16","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1074\/jbc.M608251200","article-title":"Membrane cholesterol content modulates ClC-2 gating and sensitivity to oxidative stress","volume":"282","author":"Hinzpeter","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1593\/neo.12444_bib17","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1074\/jbc.M410385200","article-title":"Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor","volume":"280","author":"Harikumar","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1593\/neo.12444_bib18","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.bbamem.2009.08.016","article-title":"Sphingolipid\/cholesterol regulation of neurotransmitter receptor conformation and function","volume":"1788","author":"Fantini","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1593\/neo.12444_bib19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1039\/C0MB00148A","article-title":"Molecular modeling of the human serotonin(1A) receptor: role of membrane cholesterol in ligand binding of the receptor","volume":"7","author":"Paila","year":"2011","journal-title":"Mol Biosyst"},{"key":"10.1593\/neo.12444_bib20","doi-asserted-by":"crossref","first-page":"L11","DOI":"10.1016\/j.bpj.2010.12.3698","article-title":"The morphology and composition of cholesterol-rich micellar nanostructures determine transmembrane protein (GPCR) activity","volume":"100","author":"O'Malley","year":"2011","journal-title":"Biophys J"},{"key":"10.1593\/neo.12444_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/srep00069","article-title":"Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor","volume":"1","author":"Baier","year":"2011","journal-title":"Sci Rep"},{"issue":"pt 2","key":"10.1593\/neo.12444_bib22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/bj3120471","article-title":"Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin","volume":"312","author":"Kaliman","year":"1995","journal-title":"Biochem J"},{"key":"10.1593\/neo.12444_bib23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s11307-009-0294-0","article-title":"Degree of tumor FDG uptake correlates with proliferation index in triple negative breast cancer","volume":"12","author":"Tchou","year":"2010","journal-title":"Mol Imaging Biol"},{"key":"10.1593\/neo.12444_bib24","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1593\/neo.12444_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2007.03.006","article-title":"The GLUT4 glucose transporter","volume":"5","author":"Huang","year":"2007","journal-title":"Cell Metab"},{"key":"10.1593\/neo.12444_bib26","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.bbalip.2010.02.003","article-title":"Limited cholesterol depletion causes aggregation of plasma membrane lipid rafts inducing T cell activation","volume":"1801","author":"Mahammad","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1593\/neo.12444_bib27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.clinbiochem.2007.03.016","article-title":"Mevalonate pathway: a review of clinical and therapeutical implications","volume":"40","author":"Buhaescu","year":"2007","journal-title":"Clin Biochem"},{"key":"10.1593\/neo.12444_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.molmed.2007.11.004","article-title":"Pleiotropic effects of statin therapy: molecular mechanisms and clinical results","volume":"14","author":"Wang","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.1593\/neo.12444_bib29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.45.120403.095748","article-title":"Pleiotropic effects of statins","volume":"45","author":"Liao","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1593\/neo.12444_bib30","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1593\/neo.12444_bib31","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1161\/01.CIR.103.3.357","article-title":"Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study","volume":"103","author":"Freeman","year":"2001","journal-title":"Circulation"},{"key":"10.1593\/neo.12444_bib32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(09)61965-6","article-title":"Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials","volume":"375","author":"Sattar","year":"2010","journal-title":"Lancet"},{"key":"10.1593\/neo.12444_bib33","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1001\/jama.2011.860","article-title":"Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis","volume":"305","author":"Preiss","year":"2011","journal-title":"JAMA"},{"key":"10.1593\/neo.12444_bib34","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/MOL.0b013e3282364add","article-title":"Niacin in cardiovascular prevention: mechanisms, efficacy, and safety","volume":"18","author":"Guyton","year":"2007","journal-title":"Curr Opin Lipidol"},{"key":"10.1593\/neo.12444_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1194\/jlr.R500012-JLR200","article-title":"Lipid posttranslational modifications. Farnesyl transferase inhibitors","volume":"47","author":"Basso","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1593\/neo.12444_bib36","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/89058","article-title":"Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site","volume":"7","author":"Weitz-Schmidt","year":"2001","journal-title":"Nat Med"},{"key":"10.1593\/neo.12444_bib37","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2007.02.049","article-title":"The role of coenzyme Q10 in statinassociated myopathy: a systematic review","volume":"49","author":"Marcoff","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1593\/neo.12444_bib38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ab.2009.09.020","article-title":"HPLC and mass spectrometry analysis of dolichol-phosphates at the cell culture scale","volume":"396","author":"Haeuptle","year":"2010","journal-title":"Anal Biochem"},{"key":"10.1593\/neo.12444_bib39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.atherosclerosis.2003.11.004","article-title":"Fluvastatin inhibits raft dependent Fc\u03b3 receptor signalling in human monocytes","volume":"172","author":"Hillyard","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1593\/neo.12444_bib40","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1172\/JCI200519935","article-title":"Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts","volume":"115","author":"Zhuang","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1593\/neo.12444_bib41","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature04399","article-title":"Role of cholesterol and lipid organization in disease","volume":"438","author":"Maxfield","year":"2005","journal-title":"Nature"},{"key":"10.1593\/neo.12444_bib42","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.290.5497.1721","article-title":"How cells handle cholesterol","volume":"290","author":"Simons","year":"2000","journal-title":"Science"},{"key":"10.1593\/neo.12444_bib43","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1073\/pnas.0809959106","article-title":"Effect of cholesterol on the structure of a phospholipid bilayer","volume":"106","author":"de Meyer","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1593\/neo.12444_bib44","doi-asserted-by":"crossref","first-page":"E141","DOI":"10.1152\/ajpendo.00712.2009","article-title":"Glucose transporters in the 21st century","volume":"298","author":"Thorens","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1593\/neo.12444_bib45","doi-asserted-by":"crossref","first-page":"E836","DOI":"10.1152\/ajpendo.00496.2009","article-title":"Will the original glucose transporter isoform please stand up!","volume":"297","author":"Carruthers","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1593\/neo.12444_bib46","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nmeth0610-429","article-title":"Making membrane proteins for structures: a trillion tiny tweaks","volume":"7","author":"Baker","year":"2010","journal-title":"Nat Methods"},{"key":"10.1593\/neo.12444_bib47","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nature06325","article-title":"Crystal structure of the human \u03b22 adrenergic G-protein-coupled receptor","volume":"450","author":"Rasmussen","year":"2007","journal-title":"Nature"},{"key":"10.1593\/neo.12444_bib48","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1126\/science.1161302","article-title":"Solution structure of the integral human membrane protein VDAC-1 in detergent micelles","volume":"321","author":"Hiller","year":"2008","journal-title":"Science"},{"key":"10.1593\/neo.12444_bib49","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-90-481-8622-8_9","article-title":"Cholesterol interaction with proteins that partition into membrane domains: an overview","volume":"51","author":"Epand","year":"2010","journal-title":"Subcell Biochem"},{"key":"10.1593\/neo.12444_bib50","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1093\/nar\/gkg557","article-title":"GeneSilico protein structure prediction meta-server","volume":"31","author":"Kurowski","year":"2003","journal-title":"Nucleic Acids Res"},{"issue":"suppl 6","key":"10.1593\/neo.12444_bib51","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/prot.10545","article-title":"A \u201cFRankenstein's monster\u201d approach to comparative modeling: merging the finest fragments of fold-recognition models and iterative model refinement aided by 3D structure evaluation","volume":"53","author":"Kosinski","year":"2003","journal-title":"Proteins"},{"key":"10.1593\/neo.12444_bib52","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/pros.21131","article-title":"Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells","volume":"70","author":"Parikh","year":"2010","journal-title":"Prostate"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558612800686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558612800686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T21:53:14Z","timestamp":1747950794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558612800686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S1476558612800686"],"URL":"https:\/\/doi.org\/10.1593\/neo.12444","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}