{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:40:42Z","timestamp":1761489642741},"reference-count":36,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":216,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1593\/neo.131368","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T13:12:02Z","timestamp":1429794722000},"page":"1184-1195","source":"Crossref","is-referenced-by-count":20,"title":["A Novel Ras Inhibitor (MDC-1016) Reduces Human Pancreatic Tumor Growth in Mice"],"prefix":"10.1016","volume":"15","author":[{"given":"Gerardo G","family":"Mackenzie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren E","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Papayannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninche","family":"Alston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kvetoslava","family":"Vrankova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nengtai","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basil","family":"Rigas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1593\/neo.131368_bib1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1056\/NEJMra0901557","article-title":"Pancreatic cancer","volume":"362","author":"Hidalgo","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1593\/neo.131368_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/caac.20138","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"10.1593\/neo.131368_bib3","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3748\/wjg.v18.i8.736","article-title":"Developments in metastatic pancreatic cancer: is gemcitabine still the standard?","volume":"18","author":"Ying","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1593\/neo.131368_bib4","first-page":"545","article-title":"K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization","volume":"143","author":"Hruban","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1593\/neo.131368_bib5","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrc2899","article-title":"KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma","volume":"10","author":"Morris","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1593\/neo.131368_bib6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1158\/1541-7786.MCR-11-0399","article-title":"Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1","volume":"10","author":"Botta","year":"2012","journal-title":"Mol Cancer Res"},{"key":"10.1593\/neo.131368_bib7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1158\/2159-8290.CD-11-0347","article-title":"A central role for RAF\u2192MEK\u2192ERK signaling in the genesis of pancreatic ductal adenocarcinoma","volume":"2","author":"Collisson","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1593\/neo.131368_bib8","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1158\/0008-5472.CAN-04-2848","article-title":"Pharmacologic inhibition of RAF\u2192MEK\u2192ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1","volume":"65","author":"Gysin","year":"2005","journal-title":"Cancer Res"},{"key":"10.1593\/neo.131368_bib9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1172\/JCI12807","article-title":"Therapeutic targeting of the MEK\/MAPK signal transduction module in acute myeloid leukemia","volume":"108","author":"Milella","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1593\/neo.131368_bib10","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.2174\/1381612023393026","article-title":"BAY 43-9006: preclinical data","volume":"8","author":"Wilhelm","year":"2002","journal-title":"Curr Pharma Des"},{"key":"10.1593\/neo.131368_bib11","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/sj.leu.2402824","article-title":"Involvement of PI3K\/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy","volume":"17","author":"Chang","year":"2003","journal-title":"Leukemia"},{"key":"10.1593\/neo.131368_bib12","doi-asserted-by":"crossref","first-page":"11712","DOI":"10.1073\/pnas.1634990100","article-title":"Akt as a mediator of cell death","volume":"100","author":"Luo","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1593\/neo.131368_bib13","first-page":"3279","article-title":"The role of Akt activation in the response to chemotherapy in pancreatic cancer","volume":"30","author":"Parsons","year":"2010","journal-title":"Anticancer Res"},{"key":"10.1593\/neo.131368_bib14","first-page":"989","article-title":"Inhibition of the phosphatidylinositol 3\u2032-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo","volume":"1","author":"Bondar","year":"2002","journal-title":"Mol Cancer Ther"},{"key":"10.1593\/neo.131368_bib15","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1053\/j.gastro.2013.01.071","article-title":"Roles for KRAS in pancreatic tumor development and progression","volume":"144","author":"di Magliano","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1593\/neo.131368_bib16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1172\/JCI59227","article-title":"Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice","volume":"122","author":"Collins","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1593\/neo.131368_bib17","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s10637-012-9818-6","article-title":"Integrated preclinical and clinical development of S-trans, trans-farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer","volume":"30","author":"Laheru","year":"2012","journal-title":"Invest New Drugs"},{"key":"10.1593\/neo.131368_bib18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0076-6879(07)00432-6","article-title":"The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer","volume":"439","author":"Rotblat","year":"2008","journal-title":"Methods Enzymol"},{"key":"10.1593\/neo.131368_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1021\/jm801165r","article-title":"New derivatives of farnesylthiosalicylic acid (Salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models","volume":"52","author":"Goldberg","year":"2009","journal-title":"J Med Chem"},{"key":"10.1593\/neo.131368_bib20","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/j.1476-5381.2010.01162.x","article-title":"The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats","volume":"162","author":"Huang","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1593\/neo.131368_bib21","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1158\/0008-5472.CAN-11-2349","article-title":"Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds","volume":"71","author":"Huang","year":"2011","journal-title":"Cancer Res"},{"key":"10.1593\/neo.131368_bib22","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1053\/j.gastro.2010.06.044","article-title":"Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice","volume":"139","author":"Mackenzie","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1593\/neo.131368_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061532","article-title":"Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice","volume":"8","author":"Mackenzie","year":"2013","journal-title":"PLoS One"},{"key":"10.1593\/neo.131368_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/ijc.23477","article-title":"Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-\u03baB and STAT3 pathways in Hodgkin's lymphoma cells","volume":"123","author":"Mackenzie","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1593\/neo.131368_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00280-007-0451-6","article-title":"Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice","volume":"61","author":"Haklai","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1593\/neo.131368_bib26","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1158\/1940-6207.CAPR-11-0067","article-title":"Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice","volume":"4","author":"Mackenzie","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1593\/neo.131368_bib27","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1056\/NEJM199305203282001","article-title":"International Pancreatitis Study Group Pancreatitis and the risk of pancreatic cancer","volume":"328","author":"Lowenfels","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1593\/neo.131368_bib28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ccr.2007.01.012","article-title":"Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice","volume":"11","author":"Guerra","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1593\/neo.131368_bib29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ccr.2011.03.002","article-title":"Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression","volume":"19","author":"Fukuda","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1593\/neo.131368_bib30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1158\/1940-6207.CAPR-08-0042","article-title":"Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial","volume":"1","author":"Meyskens","year":"2008","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1593\/neo.131368_bib31","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ccr.2011.03.009","article-title":"Stat3\/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer","volume":"19","author":"Lesina","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1593\/neo.131368_bib32","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1124\/jpet.111.183533","article-title":"Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents","volume":"338","author":"Sun","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1593\/neo.131368_bib33","doi-asserted-by":"crossref","first-page":"R20","DOI":"10.1186\/bcr3105","article-title":"Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system","volume":"14","author":"Sun","year":"2012","journal-title":"Breast Cancer Res"},{"key":"10.1593\/neo.131368_bib34","first-page":"227","article-title":"AKT: a novel target in pancreatic cancer therapy","volume":"2","author":"Mortenson","year":"2004","journal-title":"Cancer Ther"},{"key":"10.1593\/neo.131368_bib35","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol Rev"},{"key":"10.1593\/neo.131368_bib36","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1158\/0008-5472.CAN-11-0908","article-title":"STAT3 plays acriticalrolein KRAS-induced pancreatic tumorigenesis","volume":"71","author":"Corcoran","year":"2011","journal-title":"Cancer Res"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147655861380108X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147655861380108X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T07:27:02Z","timestamp":1537687622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147655861380108X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S147655861380108X"],"URL":"https:\/\/doi.org\/10.1593\/neo.131368","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}