{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:28:18Z","timestamp":1770978498514,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":1919,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1593\/neo.81150","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T13:00:30Z","timestamp":1429794030000},"page":"136-144","source":"Crossref","is-referenced-by-count":47,"title":["Enhanced Ovarian Cancer Tumorigenesis and Metastasis by the Macrophage Colony-Stimulating Factor"],"prefix":"10.1016","volume":"11","author":[{"given":"Eugene P.","family":"Toy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Azodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy L.","family":"Folk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina M.","family":"Zito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline J.","family":"Zeiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko K.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1593\/neo.81150_bib1","first-page":"999","article-title":"Overexpression of epithelial CSF-1 and CSF-1 receptor: a poor prognostic factor in epithelial ovarian cancer; contrasted with a positive effect of stromal CSF-1","volume":"3","author":"Chambers","year":"1997","journal-title":"Clin Cancer Res"},{"key":"10.1593\/neo.81150_bib2","first-page":"135","article-title":"Ovarian adenocarcinomas express fms complementary transcripts and fms antigen, often with co-expression of CSF-1","volume":"137","author":"Kacinski","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1593\/neo.81150_bib3","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/1097-0142(19910215)67:4<990::AID-CNCR2820670422>3.0.CO;2-8","article-title":"Expression of macrophage colony stimulating factor and its receptor in gynecologic malignancies","volume":"67","author":"Baiocchi","year":"1998","journal-title":"Cancer"},{"key":"10.1593\/neo.81150_bib4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/bjc.1994.62","article-title":"Circulating levels of colony-stimulating factor 1 as a prognostic indicator in 82 patients with epithelial ovarian cancer","volume":"62","author":"Scholl","year":"1994","journal-title":"Br J Cancer"},{"key":"10.1593\/neo.81150_bib5","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0002-9378(93)90485-2","article-title":"Colony stimulating factor-1 in primary ascites of ovarian cancer is a significant predictor of survival","volume":"168","author":"Price","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1593\/neo.81150_bib6","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0002-9378(12)90761-9","article-title":"Increased serum levels of macrophage colony stimulating factor in ovarian cancer","volume":"165","author":"Xu","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1593\/neo.81150_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0360-3016(89)90383-0","article-title":"Circulating levels of CSF-1 (CSF-1) a lymphohematopoietic cytokine may be a useful marker of disease status in patients with malignant ovarian neoplasms","volume":"17","author":"Kacinski","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1593\/neo.81150_bib8","first-page":"667","article-title":"Colony Stimulating Factor 1 (macrophage colony stimulating factor)","volume":"95","author":"Sherr","year":"1990"},{"issue":"9","key":"10.1593\/neo.81150_bib9","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1158\/0008-5472.CAN-04-3954","article-title":"Glyceraldehyde-3-phosphate dehydrogenase binds to the AU-rich 3\u2032-untranslated region of colony-stimulating factor (CSF-1) messenger RNA in human ovarian cancer cells: possible role in CSF-1 post-transcriptional regulation and tumor phenotype","volume":"65","author":"Bonafe","year":"2005","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81150_bib10","first-page":"1578","article-title":"Macrophage colony stimulating factor mediates invasion of ovarian cancer cells through urokinase","volume":"55","author":"Chambers","year":"1995","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81150_bib11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1525-1438.1998.09818.x","article-title":"Urokinase-type plasminogen activator in epithelial ovarian cancer: a poor prognostic factor, associated with advanced stage","volume":"8","author":"Chambers","year":"1998","journal-title":"Int J Gynecol Cancer"},{"key":"10.1593\/neo.81150_bib12","first-page":"2513","article-title":"High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with a poor prognosis","volume":"53","author":"Grondahl-Hansen","year":"1993","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81150_bib13","first-page":"3668","article-title":"Comparative properties of five human ovarian adenocarcinoma cell lines","volume":"45","author":"Buick","year":"1985","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81150_bib14","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.3493529","article-title":"Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein","volume":"235","author":"Wong","year":"1987","journal-title":"Science (Washington DC)"},{"key":"10.1593\/neo.81150_bib15","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1021\/bi00591a005","article-title":"Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease","volume":"18","author":"Chirgwin","year":"1979","journal-title":"Biochemistry"},{"key":"10.1593\/neo.81150_bib16","first-page":"529","article-title":"Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoids","volume":"10","author":"Sapi","year":"1995","journal-title":"Oncogene"},{"key":"10.1593\/neo.81150_bib17","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.ajog.2004.01.021","article-title":"An unexpected effect of glucocorticoids on stimulation of c-fms proto-oncogene expression in choriocarcinoma cells expressing little glucocorticoid receptor","volume":"190","author":"Chambers","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1593\/neo.81150_bib18","series-title":"Methods in Molecular Medicine, Ovarian Cancer","first-page":"179","article-title":"In vitro invasion assays","author":"Chambers","year":"2000"},{"key":"10.1593\/neo.81150_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0304-3835(87)90209-6","article-title":"A simple quantitative assay for studying the invasive potential of high and low human metastatic variants","volume":"38","author":"Hendrix","year":"1987","journal-title":"Cancer Lett"},{"key":"10.1593\/neo.81150_bib20","first-page":"2553","article-title":"Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines: an important new class of selective synthetic urokinase inhibitor","volume":"53","author":"Towle","year":"1993","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81150_bib21","first-page":"3610","article-title":"Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B","volume":"52","author":"Kobayashi","year":"1992","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81150_bib22","first-page":"3696","article-title":"Recombinant human uteroglobin inhibits the in vitro invasiveness of human metastatic prostate tumor cells and the release of arachidonic acid stimulated by fibroblast-conditioned medium","volume":"54","author":"Leyton","year":"1994","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81150_bib23","first-page":"4366","article-title":"Suppression of malignancy by the 3\u2032 untranslated regions of ribonucleotide reductase R1 and R2 messsenger RNAs","volume":"56","author":"Fan","year":"1996","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81150_bib24","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0092-8674(93)90579-F","article-title":"Genetic complementation reveals a novel regulatory role for 3\u2032 untranslated regions in growth and differentiation","volume":"72","author":"Rastinejad","year":"1993","journal-title":"Cell"},{"key":"10.1593\/neo.81150_bib25","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/0092-8674(93)90320-P","article-title":"Tumor suppression by RNA from the 3\u2032 untranslated region of \u03b1-tropomyosin","volume":"75","author":"Rastinejad","year":"1993","journal-title":"Cell"},{"issue":"8","key":"10.1593\/neo.81150_bib26","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1158\/1541-7786.MCR-07-2170","article-title":"The multifunctional protein glyceraldehyde-3-phosphate dehydrogenase is both regulated and controls CSF-1 mRNA stability in ovarian cancer","volume":"6","author":"Zhou","year":"2008","journal-title":"Mol Cancer Res"},{"issue":"8","key":"10.1593\/neo.81150_bib27","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/ncb1616","article-title":"Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion","volume":"9","author":"Wolf","year":"2007","journal-title":"Nat Cell Biol"},{"issue":"2","key":"10.1593\/neo.81150_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/med.20078","article-title":"Can anti-migratory drugs be screened in vitro? A review of 2D and 3D assays for the quantitative analysis of cell migration","volume":"27","author":"Decaestecker","year":"2007","journal-title":"Med Res Rev"},{"key":"10.1593\/neo.81150_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrc1256","article-title":"Tumour-educated macrophages promote tumour progression and metastasis","volume":"4","author":"Pollard","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1593\/neo.81150_bib30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2174\/138955708783744074","article-title":"Strategies for in vivo siRNA delivery in cancer","volume":"8","author":"Sanguino","year":"2008","journal-title":"Mini Rev Med Chem"},{"issue":"7175","key":"10.1593\/neo.81150_bib31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nature06487","article-title":"Endogenous human microRNAs that suppress breast cancer metastasis","volume":"451","author":"Tavazoie","year":"2008","journal-title":"Nature"},{"issue":"11","key":"10.1593\/neo.81150_bib32","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1158\/1078-0432.CCR-07-2020","article-title":"Nonviral nanoscale-based delivery of antisense oligonucleotides targeted to hypoxia-inducible factor 1 alpha enhances the efficacy of chemotherapy in drug-resistant tumor","volume":"14","author":"Wang","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1593\/neo.81150_bib33","first-page":"5704","article-title":"Independent regulation of invasion and anchorageindependent growth by different autophosphorylation sites of the macrophage colony-stimulating factor 1 receptor","volume":"56","author":"Sapi","year":"1996","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81150_bib34","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/gyno.2000.6070","article-title":"The activated macrophage colony stimulating factor (CSF-1) receptor as an indicator of poor outcome in advanced epithelial ovarian carcinoma","volume":"80","author":"Toy","year":"2001","journal-title":"Gynecol Oncol"},{"key":"10.1593\/neo.81150_bib35","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.193.6.727","article-title":"Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy","volume":"193","author":"Lin","year":"2001","journal-title":"J Exp Med"},{"key":"10.1593\/neo.81150_bib36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1158\/1078-0432.CCR-0699-3","article-title":"Macrophage colony-stimulating factor-1 receptor expression is associated with poor outcome in breast cancer by large cohort tissue microarray analysis","volume":"10","author":"Kluger","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1593\/neo.81150_bib37","series-title":"Ovarian Cancer","article-title":"Biomarker targets and novel therapeutics","author":"Clouser","year":"2008"},{"issue":"4","key":"10.1593\/neo.81150_bib38","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1525-1438.2007.00882.x","article-title":"Phase II trial of imatinib mesylate in recurrent, biomarker positive, ovarian cancer (Southwest Oncology Group Protocol S0211)","volume":"17","author":"Alberts","year":"2007","journal-title":"Int J Gynecol Cancer"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558609800262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558609800262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T07:50:14Z","timestamp":1537689014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558609800262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S1476558609800262"],"URL":"https:\/\/doi.org\/10.1593\/neo.81150","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}