{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:43:25Z","timestamp":1774122205389,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":1891,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1593\/neo.81480","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T13:09:24Z","timestamp":1429794564000},"page":"298-304","source":"Crossref","is-referenced-by-count":20,"title":["The Angiopoietin\/Tie2 Axis Mediates Malignant Pleural Effusion Formation"],"prefix":"10.1016","volume":"11","author":[{"given":"Charalampos","family":"Moschos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Psallidas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Androniki","family":"Kollintza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Karabela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Papapetropoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyros","family":"Papiris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Light","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charis","family":"Roussos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios T.","family":"Stathopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Kalomenidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1593\/neo.81480_bib1","series-title":"Pleural Diseases","first-page":"108","author":"Light","year":"2001"},{"key":"10.1593\/neo.81480_bib2","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1164\/ajrccm.162.5.ats8-00","article-title":"Management of malignant pleural effusions","volume":"162","author":"Antony","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1593\/neo.81480_bib3","series-title":"Fishman\u2019s Pulmonary Diseases and Disorders","first-page":"1429","article-title":"Malignant Pleural Effusions","author":"Sahn","year":"1998"},{"key":"10.1593\/neo.81480_bib4","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1378\/chest.122.5.1506","article-title":"Talc for pleurodesis?","volume":"122","author":"Light","year":"2002","journal-title":"Chest"},{"key":"10.1593\/neo.81480_bib5","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/S0002-9440(10)64828-6","article-title":"Production of experimental malignant pleural effusions is dependent on invasion of the pleura and expression of vascular endothelial growth factor\/vascular permeability factor by human lung cancer cells","volume":"157","author":"Yano","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1593\/neo.81480_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1165\/rcmb.2005-0130OC","article-title":"Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion","volume":"34","author":"Stathopoulos","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1593\/neo.81480_bib7","doi-asserted-by":"crossref","first-page":"9825","DOI":"10.1158\/0008-5472.CAN-07-1064","article-title":"Tumor necrosis factor-alpha promotes malignant pleural effusion","volume":"67","author":"Stathopoulos","year":"2007","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81480_bib8","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1093\/jnci\/djn325","article-title":"Tumor-derived monocyte chemoattractant protein-1 promotes malignant pleural effusion","volume":"100","author":"Stathopoulos","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"10.1593\/neo.81480_bib9","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1517\/13543784.12.6.933","article-title":"Angiopoietins in angio-genesis and beyond","volume":"12","author":"Tsigkos","year":"2003","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1593\/neo.81480_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1618","article-title":"Angiopoietins in tumours: the angiogenic switch","volume":"204","author":"Tait","year":"2004","journal-title":"J Pathol"},{"key":"10.1593\/neo.81480_bib11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/10739680590960296","article-title":"Angiopoietin affects neutrophil migration","volume":"12","author":"Sturn","year":"2005","journal-title":"Microcirculation"},{"key":"10.1593\/neo.81480_bib12","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1182\/blood-2004-09-3531","article-title":"Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses.","volume":"105","author":"Lemieux","year":"2005","journal-title":"Blood"},{"key":"10.1593\/neo.81480_bib13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nm1351","article-title":"Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation","volume":"12","author":"Fiedler","year":"2006","journal-title":"Nat Med"},{"key":"10.1593\/neo.81480_bib14","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.1182\/blood-2006-10-053504","article-title":"Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer","volume":"109","author":"Venneri","year":"2007","journal-title":"Blood"},{"key":"10.1593\/neo.81480_bib15","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1124\/jpet.105.086553","article-title":"Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage","volume":"14","author":"Roviezzo","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1593\/neo.81480_bib16","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1378\/chest.129.5.1259","article-title":"Angiopoietin-2 levels are elevated in exudative pleural effusions","volume":"129","author":"Kalomenidis","year":"2006","journal-title":"Chest"},{"key":"10.1593\/neo.81480_bib17","first-page":"733","article-title":"Analysis of proliferative grade using anti-PCNA\/cyclin monoclonal antibodies in fixed, embedded tissues. Comparison with flow cytometric analysis","volume":"134","author":"Garcia","year":"1989","journal-title":"Am J Pathol"},{"key":"10.1593\/neo.81480_bib18","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0092-8674(01)00599-2","article-title":"IKK\u03b1 provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.","volume":"107","author":"Cao","year":"2001","journal-title":"Cell"},{"key":"10.1593\/neo.81480_bib19","first-page":"4557","article-title":"Comparative morphometric study of tumor vasculature in human squamous cell carcinomas and their xenotransplants in athymic nude mice","volume":"49","author":"Lauk","year":"1989","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81480_bib20","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1038\/sj.onc.1209464","article-title":"Autocrine IL-6\u2013 induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion","volume":"25","author":"Yeh","year":"2006","journal-title":"Oncogene"},{"key":"10.1593\/neo.81480_bib21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1593\/neo.06109","article-title":"Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth.","volume":"8","author":"Lee","year":"2006","journal-title":"Neoplasia"},{"key":"10.1593\/neo.81480_bib22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1158\/1541-7786.MCR-07-0072","article-title":"Angiopoietin: a TIE(d) balance in tumor angiogenesis","volume":"5","author":"Shim","year":"2007","journal-title":"Mol Cancer Res"},{"key":"10.1593\/neo.81480_bib23","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1097\/01.LAB.0000097189.79233.D8","article-title":"Angiopoietin\/Tek interactions regulate mmp-9 expression and retinal neovascularization","volume":"83","author":"Das","year":"2003","journal-title":"Lab Invest"},{"key":"10.1593\/neo.81480_bib24","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1089\/104303401750270968","article-title":"Systemically expressed soluble Tie2 inhibits intraocular neovascularization","volume":"12","author":"Hangai","year":"2001","journal-title":"Hum Gene Ther"},{"key":"10.1593\/neo.81480_bib25","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1161\/01.RES.87.7.603","article-title":"Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions","volume":"87","author":"Gamble","year":"2000","journal-title":"Circ Res"},{"key":"10.1593\/neo.81480_bib26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/hh1801.097034","article-title":"Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression","volume":"89","author":"Kim","year":"2001","journal-title":"Circ Res"},{"key":"10.1593\/neo.81480_bib27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccr.2005.08.002","article-title":"Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors","volume":"8","author":"De Palma","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1593\/neo.81480_bib28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cellimm.2005.06.001","article-title":"Expression and regulation of murine macrophage angiopoietin-2","volume":"234","author":"Hubbard","year":"2005","journal-title":"Cell Immunol"},{"key":"10.1593\/neo.81480_bib29","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.4049\/jimmunol.178.11.7405","article-title":"Expression of Tie-2 by human monocytes and their responses to angiopoietin-2","volume":"178","author":"Murdoch","year":"2007","journal-title":"J Immunol"},{"key":"10.1593\/neo.81480_bib30","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0002-9440(10)63998-3","article-title":"Angiopoietin-2 is implicated in the regulation of tumor angiogenesis","volume":"158","author":"Yu","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1593\/neo.81480_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.277.5322.55","article-title":"Angiopoietin2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis","volume":"277","author":"Maisonpierre","year":"1997","journal-title":"Science"},{"key":"10.1593\/neo.81480_bib32","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1038\/sj.onc.1203800","article-title":"Angiopoietin2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3\u2032-kinase\/Akt signal transduction pathway","volume":"19","author":"Kim","year":"2000","journal-title":"Oncogene"},{"key":"10.1593\/neo.81480_bib33","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0008-6363(00)00231-5","article-title":"Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2","volume":"49","author":"Teichert-Kuliszewska","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1593\/neo.81480_bib34","doi-asserted-by":"crossref","first-page":"15491","DOI":"10.1073\/pnas.0607538103","article-title":"Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells","volume":"103","author":"Daly","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1593\/neo.81480_bib35","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1096\/fj.03-1466com","article-title":"Biological characterization of angiopoietin-3 and angiopoietin-4","volume":"18","author":"Lee","year":"2004","journal-title":"FASEB J"},{"key":"10.1593\/neo.81480_bib36","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.cellsig.2006.02.015","article-title":"Angio-poietins-1 and -2 are both capable of mediating endothelial PAF synthesis: intra-cellular signalling pathways","volume":"18","author":"Maliba","year":"2006","journal-title":"Cell Signal"},{"key":"10.1593\/neo.81480_bib37","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/74725","article-title":"Angiopoietin-1 protects the adult vasculature against plasma leakage","volume":"6","author":"Thurston","year":"2000","journal-title":"Nat Med"},{"key":"10.1593\/neo.81480_bib38","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1593\/neo.06127","article-title":"Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure.","volume":"8","author":"Olsen","year":"2006","journal-title":"Neoplasia"},{"key":"10.1593\/neo.81480_bib39","doi-asserted-by":"crossref","first-page":"8829","DOI":"10.1073\/pnas.95.15.8829","article-title":"Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2","volume":"95","author":"Lin","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1593\/neo.81480_bib40","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1172\/JCI119740","article-title":"Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth","volume":"100","author":"Lin","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1593\/neo.81480_bib41","first-page":"3185","article-title":"Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway","volume":"59","author":"Siemeister","year":"1999","journal-title":"Cancer Res"},{"key":"10.1593\/neo.81480_bib42","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0002-9440(10)63137-9","article-title":"Targeting the Tie2\/Tek receptor in astrocytomas","volume":"164","author":"Zadeh","year":"2004","journal-title":"Am J Pathol"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558609801267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558609801267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T07:27:54Z","timestamp":1537687674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558609801267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S1476558609801267"],"URL":"https:\/\/doi.org\/10.1593\/neo.81480","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}