{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:05:03Z","timestamp":1762506303288,"version":"build-2065373602"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1593\/tlo.13274","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T09:58:55Z","timestamp":1395741535000},"page":"398-404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Vascular Endothelial Growth Factor C-Induced Lymphangiogenesis Decreases Tumor Interstitial Fluid Pressure and Tumor"],"prefix":"10.1016","volume":"6","author":[{"given":"Matthias","family":"Hofmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Pflanzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja Nicole","family":"Z\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"August","family":"Bernd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diamant","family":"Thaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Bereiter-Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hirohata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kippenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1593\/tlo.13274_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/00365518209168067","article-title":"Interstitial fluid pressure in DMBA-induced rat mammary tumours","volume":"42","author":"Wiig","year":"1982","journal-title":"Scan J Clin Lab Invest"},{"key":"10.1593\/tlo.13274_bib2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/scientificamerican0794-58","article-title":"Barriers to drug delivery in solid tumors","volume":"271","author":"Jain","year":"1994","journal-title":"Sci Am"},{"key":"10.1593\/tlo.13274_bib3","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nm0698-655","article-title":"The next frontier of molecular medicine: delivery of therapeutics","volume":"4","author":"Jain","year":"1998","journal-title":"Nat Med"},{"key":"10.1593\/tlo.13274_bib4","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrc1456","article-title":"High interstitial fluid pressure\u2014an obstacle in cancer therapy","volume":"4","author":"Heldin","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1593\/tlo.13274_bib5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/mvre.1999.2184","article-title":"Interstitial fluid pressure and capillary diameter distribution in human melanoma xenografts","volume":"58","author":"Tufto","year":"1999","journal-title":"Microvasc Res"},{"key":"10.1593\/tlo.13274_bib6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"10.1593\/tlo.13274_bib7","first-page":"4324","article-title":"Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation","volume":"60","author":"Leu","year":"2000","journal-title":"Cancer Res"},{"key":"10.1593\/tlo.13274_bib8","first-page":"3039","article-title":"Transport of molecules in the tumor interstitium: a review","volume":"47","author":"Jain","year":"1987","journal-title":"Cancer Res"},{"key":"10.1593\/tlo.13274_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0168-3659(01)00306-6","article-title":"Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function","volume":"74","author":"Jain","year":"2001","journal-title":"J Control Release"},{"key":"10.1593\/tlo.13274_bib10","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1158\/0008-5472.CAN-06-4102","article-title":"Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model","volume":"67","author":"Jain","year":"2007","journal-title":"Cancer Res"},{"key":"10.1593\/tlo.13274_bib11","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/427695a","article-title":"Pathology: cancer cells compress intratumour vessels","volume":"427","author":"Padera","year":"2004","journal-title":"Nature"},{"key":"10.1593\/tlo.13274_bib12","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1158\/0008-5472.CAN-04-0752","article-title":"Peritumor lymphatics induced by vascular endothelial growth factor-c exhibit abnormal function","volume":"64","author":"Isaka","year":"2004","journal-title":"Cancer Res"},{"key":"10.1593\/tlo.13274_bib13","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1126\/science.1071420","article-title":"Lymphatic metastasis in the absence of functional intratumor lymphatics","volume":"296","author":"Padera","year":"2002","journal-title":"Science"},{"key":"10.1593\/tlo.13274_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1593\/neo.05469","article-title":"Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model","volume":"8","author":"Hofmann","year":"2006","journal-title":"Neoplasia"},{"key":"10.1593\/tlo.13274_bib15","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.jbiomech.2006.10.039","article-title":"Long-term lowering of tumour interstitial fluid pressure reduces Ki-67 expression","volume":"40","author":"Hofmann","year":"2007","journal-title":"J Biomech"},{"key":"10.1593\/tlo.13274_bib16","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1593\/neo.09662","article-title":"Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumor model","volume":"11","author":"Hofmann","year":"2009","journal-title":"Neoplasia"},{"key":"10.1593\/tlo.13274_bib17","first-page":"41","article-title":"Structure, expression and receptor-binding properties of novel vascular endothelial growth factors","volume":"237","author":"Eriksson","year":"1999","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1593\/tlo.13274_bib18","first-page":"1","article-title":"Vascular endothelial growth factor: molecular and biological aspects","volume":"237","author":"Ferrara","year":"1999","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1593\/tlo.13274_bib19","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1242\/dev.122.12.3829","article-title":"VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development","volume":"122","author":"Kukk","year":"1996","journal-title":"Development"},{"key":"10.1593\/tlo.13274_bib20","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/01.RES.85.11.992","article-title":"Vascular endothelial growth factor (VEGF) and VEGF-C show overlapping binding sites in embryonic endothelia and distinct sites in differentiated adult endothelia","volume":"85","author":"Lymboussaki","year":"1999","journal-title":"Circ Res"},{"key":"10.1593\/tlo.13274_bib21","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1126\/science.276.5317.1423","article-title":"Hyperplasia of lymphatic vessels in VEGF-C transgenic mice","volume":"276","author":"Jeltsch","year":"1997","journal-title":"Science"},{"key":"10.1593\/tlo.13274_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/dbio.1997.8639","article-title":"VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane","volume":"188","author":"Oh","year":"1997","journal-title":"Dev Biol"},{"issue":"4","key":"10.1593\/tlo.13274_bib23","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/028418601750288262","article-title":"Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy","volume":"40","author":"Baumann","year":"2001","journal-title":"Acta Oncol"},{"key":"10.1593\/tlo.13274_bib24","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1111\/j.1349-7006.2012.02381.x","article-title":"Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis","volume":"103","author":"Obika","year":"2012","journal-title":"Cancer Sci"},{"key":"10.1593\/tlo.13274_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0026-2862(77)90138-8","article-title":"Interstitial fluid pressure in rats measured with a modified wick technique","volume":"14","author":"Fadnes","year":"1997","journal-title":"Microvasc Res"},{"key":"10.1593\/tlo.13274_bib26","first-page":"291","article-title":"Ultrasonic quantification of tumor interstitial fluid pressure through scanning acoustic microscopy","volume":"31","author":"Pflanzer","year":"2012"},{"key":"10.1593\/tlo.13274_bib27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00535-009-0152-5","article-title":"Expression of LYVE-1 in sinusoidal endothelium is reduced in chronically inflamed human livers","volume":"45","author":"Arimoto","year":"2010","journal-title":"J Gastroenterol"},{"key":"10.1593\/tlo.13274_bib28","first-page":"2814","article-title":"Diffusion and convection in normal and neoplastic tissues","volume":"34","author":"Swabb","year":"1974","journal-title":"Cancer Res"},{"key":"10.1593\/tlo.13274_bib29","first-page":"5110","article-title":"Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse","volume":"52","author":"Boucher","year":"1992","journal-title":"Cancer Res"},{"issue":"3","key":"10.1593\/tlo.13274_bib30","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/bjc.1994.89","article-title":"Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline","volume":"69","author":"Lee","year":"1994","journal-title":"Br J Cancer"},{"key":"10.1593\/tlo.13274_bib31","first-page":"1993","article-title":"Interstitial hypertension in head and neck tumors in patients: correlation with tumor size","volume":"52","author":"Gutmann","year":"1992","journal-title":"Cancer Res"},{"key":"10.1593\/tlo.13274_bib32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF03187139","article-title":"Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma","volume":"1","author":"Nathanson","year":"1994","journal-title":"Ann Surg Oncol"},{"key":"10.1593\/tlo.13274_bib33","first-page":"4251","article-title":"Oncotic pressure in solid tumors is elevated","volume":"60","author":"Stohrer","year":"2000","journal-title":"Cancer Res"},{"key":"10.1593\/tlo.13274_bib34","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1002\/jor.20633","article-title":"Tumor interstitial fluid pressure may regulate angiogenic factors in osteosarcoma","volume":"26","author":"Nathan","year":"2008","journal-title":"J Orthop Res"},{"key":"10.1593\/tlo.13274_bib35","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"Cursiefen","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1593\/tlo.13274_bib36","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1182\/blood-2007-01-066811","article-title":"VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes","volume":"110","author":"Halin","year":"2007","journal-title":"Blood"},{"key":"10.1593\/tlo.13274_bib37","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1084\/jem.20041896","article-title":"VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis","volume":"201","author":"Hirakawa","year":"2005","journal-title":"J Exp Med"},{"key":"10.1593\/tlo.13274_bib38","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/84635","article-title":"VEGF-D promotes the metastatic spread of tumor cells via the lymphatics","volume":"7","author":"Stacker","year":"2001","journal-title":"Nat Med"},{"key":"10.1593\/tlo.13274_bib39","doi-asserted-by":"crossref","first-page":"e000877","DOI":"10.1161\/JAHA.112.000877","article-title":"Therapeutic lymphangiogenesis with implantation of adipose-derived regenerative cells","volume":"1","author":"Shimizu","year":"2012","journal-title":"J Am Heart Assoc"},{"key":"10.1593\/tlo.13274_bib40","first-page":"671","article-title":"Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis","volume":"20","author":"Mandiota","year":"2001","journal-title":"EMBO J"}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523313800605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523313800605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T14:29:15Z","timestamp":1761834555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523313800605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S1936523313800605"],"URL":"https:\/\/doi.org\/10.1593\/tlo.13274","relation":{},"ISSN":["1936-5233"],"issn-type":[{"type":"print","value":"1936-5233"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular Endothelial Growth Factor C-Induced Lymphangiogenesis Decreases Tumor Interstitial Fluid Pressure and Tumor","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1593\/tlo.13274","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Neoplasia Press, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}