{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:50:17Z","timestamp":1780483817719,"version":"3.54.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to evaluate the transverse craniofacial form in families with nonsyndromic cleft lip and palate (NSCLP). It was hypothesized that affected as well as noncleft NSCLP family members are characterized by a common array of craniofacial features that differ from the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This was a prospective cross-sectional investigation that included affected children with NSCLP and their noncleft parents and siblings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients, Participants<\/jats:title>\n                    <jats:p>A total of 114 subjects (14 affected girls, 17 affected girls, 15 unaffected male siblings, 10 unaffected female siblings, 29 unaffected biological mothers, and 29 unaffected biological fathers) were included. Subject records comprised of posteroanterior cephalometric radiographs obtained from all 114 subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>The width of midfacial structures, including the orbit and nose, was increased in NSCLP families, compared with published norms. Interestingly, the face was disproportionally wider in relation to total facial height. The transverse craniofacial form of children with or without clefts significantly correlated with that of their parents. Mothers displayed strong correlation with their affected and unaffected sons, whereas fathers correlated to their daughters, suggesting a possible sex-linked developmental influence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Better understanding of the genetic inheritance of craniofacial features associated with cleft lip and palate may ultimately contribute to the development of cleft risk assessment methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/02-134.1","type":"journal-article","created":{"date-parts":[[2004,5,19]],"date-time":"2004-05-19T18:03:35Z","timestamp":1084989815000},"page":"256-261","source":"Crossref","is-referenced-by-count":15,"title":["Transverse Craniofacial Features and Their Genetic Predisposition in Families with Nonsyndromic Unilateral Cleft Lip and Palate"],"prefix":"10.1177","volume":"41","author":[{"given":"Young-Jooh","family":"Yoon","sequence":"first","affiliation":[{"name":"Eastman Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York"},{"name":"Department of Orthodontics, College of Dentistry, Chosun University, Gwang-Ju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja R.","family":"Perkiomaki","sequence":"additional","affiliation":[{"name":"Department of Oral Development and Orthodontics, Institute of Dentistry, University of Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross H.","family":"Tallents","sequence":"additional","affiliation":[{"name":"Prosthodontics and Program Director of Temporomandibular Joint Disorders, University of Rochester, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Barillas","sequence":"additional","affiliation":[{"name":"Institute of Reconstructive Plastic Surgery, Craniofacial Center, Medical Center, and Clinical Consultant for Surgical Orthodontics, Cleft Lip and Palate Clinic, National Children's Hospital, San Jos\u00e9, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Herrera-Guido","sequence":"additional","affiliation":[{"name":"Cleft Lip and Palate Clinic, National Children's Hospital, San Jos\u00e9, and Medical Director in Hospital Cima, San Jos\u00e9, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-To","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Rochester, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanos","family":"Kyrkanides","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, and Craniofacial Research Core Coordinator, Eastman Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,5,1]]},"reference":[{"key":"bibr1-02-134.1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040208"},{"key":"bibr2-02-134.1","first-page":"270","volume":"50","author":"Farrall M.","year":"1992","journal-title":"Am J Hum Genet."},{"key":"bibr3-02-134.1","first-page":"247","volume":"16","author":"Figalova P.","year":"1974","journal-title":"Acta Chir Plast."},{"key":"bibr4-02-134.1","first-page":"336","volume":"22","author":"Fraser F.C.","year":"1970","journal-title":"Am J Hum 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