{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:24:27Z","timestamp":1777523067426,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine if Chinese individuals with nonsyndromic cleft lip with or without cleft palate (CL\/P) display more bilateral asymmetry than do their unaffected relatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Subjects<\/jats:title>\n                    <jats:p>A case-control study of 313 individuals with CL\/P from Shanghai, China, with 201 unaffected relatives as controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Size-adjusted asymmetry scores were defined by data on middle-finger length, palm length, palpebral fissure width, and ear length. Case-control comparisons used a multivariate repeated measures analysis of variance, paired t tests, and the Wilcoxon signed rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ear-length measure showed a significant increase in fluctuating asymmetry (FA) in individuals with CL\/P compared with their unaffected relatives, which was most pronounced in the female cleft lip and palate subgroup (p = .04). No other measures showed any increase in FA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Evidence was found for increased FA, as measured by overall ear length, in Chinese individuals with nonsyndromic CL\/P, compared with their unaffected family members. The use of bilateral measurements other than dermatoglyphics may prove to be a valuable means of assessing overall developmental stability in individuals with developmental malformations and in their families.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/03-032.1","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T11:21:07Z","timestamp":1109935267000},"page":"192-196","source":"Crossref","is-referenced-by-count":15,"title":["Bilateral Asymmetry in Chinese Families with Cleft Lip with or without Cleft Palate"],"prefix":"10.1177","volume":"42","author":[{"given":"Katherine","family":"Neiswanger","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret E.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-e","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhabei Eye Hospital, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan-ning","family":"Hu","sequence":"additional","affiliation":[{"name":"Tissue Culture Center, New York Eye and Ear Infirmary and Department of Ophthalmology, New York Medical College, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Melnick","sequence":"additional","affiliation":[{"name":"Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth M.","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L.","family":"Marazita","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania."},{"name":"Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,3,1]]},"reference":[{"key":"bibr1-03-032.1","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300011071"},{"key":"bibr2-03-032.1","first-page":"309","volume-title":"On Growth and Form: Spatio-temporal Pattern Formation in Biology.","author":"Auffray J-C","year":"1999"},{"key":"bibr3-03-032.1","first-page":"341","volume":"30","author":"Balgir R.S.","year":"1993","journal-title":"Indian Pediatr."},{"key":"bibr4-03-032.1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2000_037_0274_deoncl_2.3.co_2"},{"key":"bibr5-03-032.1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.24.3.163"},{"key":"bibr6-03-032.1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980827)79:1<42::AID-AJMG11>3.0.CO;2-M"},{"key":"bibr7-03-032.1","first-page":"222","volume":"14","author":"DeBie S.","year":"1977","journal-title":"Cleft Palate J."},{"key":"bibr8-03-032.1","first-page":"814","volume":"70","author":"Deshmukh R.N.","year":"1979","journal-title":"Indian J Med Res."},{"key":"bibr9-03-032.1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg174"},{"key":"bibr10-03-032.1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1997.0115"},{"key":"bibr11-03-032.1","doi-asserted-by":"publisher","DOI":"10.1080\/03014460110112060"},{"key":"bibr12-03-032.1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8644(199701)102:1<133::AID-AJPA11>3.0.CO;2-1"},{"key":"bibr13-03-032.1","first-page":"1","volume":"23","author":"Kobyliansky E.","year":"1999","journal-title":"Coll Antropol."},{"key":"bibr14-03-032.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290409"},{"key":"bibr15-03-032.1","first-page":"441","volume":"63","author":"Livshits G.","year":"1991","journal-title":"Hum Biol."},{"key":"bibr16-03-032.1","doi-asserted-by":"publisher","DOI":"10.1080\/03014468400007431"},{"key":"bibr17-03-032.1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-971905"},{"key":"bibr18-03-032.1","doi-asserted-by":"publisher","DOI":"10.1086\/341944"},{"key":"bibr19-03-032.1","first-page":"648","volume":"51","author":"Marazita M.L.","year":"1992","journal-title":"Am J Hum Genet."},{"key":"bibr20-03-032.1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.160.4.467"},{"key":"bibr21-03-032.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(02)00262-9"},{"key":"bibr22-03-032.1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961202)66:1<15::AID-AJMG4>3.0.CO;2-V"},{"key":"bibr23-03-032.1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0544.2002.02196.x"},{"key":"bibr24-03-032.1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010715)101:4<359::AID-AJMG1421>3.0.CO;2-S"},{"key":"bibr25-03-032.1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.es.17.110186.002135"},{"key":"bibr26-03-032.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320300117"},{"key":"bibr27-03-032.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(00)00044-X"},{"key":"bibr28-03-032.1","first-page":"34","volume":"22","author":"Rintala A.E.","year":"1985","journal-title":"Cleft Palate J."},{"key":"bibr29-03-032.1","volume-title":"SAS* Procedures Guide, Version 6.12","author":"SAS Institute Inc.","year":"1994"},{"key":"bibr30-03-032.1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a019142"},{"key":"bibr31-03-032.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1983.tb01068.x"},{"key":"bibr32-03-032.1","first-page":"417","volume":"71","author":"Trivers R.","year":"1999","journal-title":"Hum Biol."},{"key":"bibr33-03-032.1","first-page":"649","volume":"15","author":"Vormittag W.","year":"1979","journal-title":"Birth Defects: Original Article Series."},{"key":"bibr34-03-032.1","first-page":"156","volume":"11","author":"Ward R.E.","year":"1991","journal-title":"J Craniofac Genet Dev Biol."},{"key":"bibr35-03-032.1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1998.0463"},{"key":"bibr36-03-032.1","first-page":"141","volume":"17","author":"Wentzlaff K.A.","year":"1997","journal-title":"J Craniofac Genet Dev Biol."},{"key":"bibr37-03-032.1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1996.0125"},{"key":"bibr38-03-032.1","doi-asserted-by":"publisher","DOI":"10.1159\/000243963"},{"key":"bibr39-03-032.1","first-page":"400","volume":"28","author":"Woolf C.M.","year":"1976","journal-title":"Am J Hum Genet."},{"key":"bibr40-03-032.1","first-page":"503","volume":"29","author":"Woolf C.M.","year":"1977","journal-title":"Am J Hum Genet."}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/03-032.1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/03-032.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:19:30Z","timestamp":1777393170000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1597\/03-032.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1597\/03-032.1"],"URL":"https:\/\/doi.org\/10.1597\/03-032.1","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}