{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:26:29Z","timestamp":1777523189129,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Type and prevalence rates of the symptoms of Hoffmeister's \u201cgenetically determined predisposition to disturbed development of the dentition\u201d were studied in patients with clefts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Data of 263 patients with nonsyndromic clefts of lip (alveolus and palate) or isolated cleft palates were examined in a retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The clefts were classified as cleft lip or cleft lip and alveolus, cleft palate, unilateral cleft lip and palate, and bilateral cleft lip and palate. All patients were scrutinized for 28 individual symptoms. Prevalences of the individual symptoms were statistically evaluated regarding cleft type and gender by using the chi-square test and were also compared with findings in patients without clefts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 97.7% of the patients with clefts, at least one symptom was found. Microdontia of individual teeth, hypodontia, and hyperodontia were the symptoms most frequently recorded. Comparison of the different cleft types revealed differences regarding the prevalences of supernumerary lateral incisors (p = .051), infraposition of deciduous molars (p &lt; .001), and atypical tooth bud position (p = .030). Comparison of the prevalences of 10 symptoms recorded in the patients with clefts with the prevalences recorded in patients without clefts showed nine symptoms were found much more frequently in the population with clefts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings support the hypothesis that clefting is part of a complex malformation associated with other dental anomalies resulting from disturbed development of the dentition. Patients with clefts are also likely to present other deficiencies of dental development and tooth eruption in both dentitions, even in regions not affected by the cleft.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/04-156.1","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T13:26:54Z","timestamp":1157635614000},"page":"457-465","source":"Crossref","is-referenced-by-count":31,"title":["Epidemiology of Hoffmeister's \u201cGenetically Determined Predisposition to Disturbed Development of the Dentition\u201d in Patients with Cleft Lip and Palate"],"prefix":"10.1177","volume":"43","author":[{"given":"Franka","family":"Stahl","sequence":"first","affiliation":[{"name":"Department of Orthodontics, University of Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie","family":"Grabowski","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University of Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Wigger","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University of Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,7,1]]},"reference":[{"key":"bibr1-04-156.1","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300011071"},{"key":"bibr2-04-156.1","first-page":"348","volume":"45","author":"Ardinger H.H.","year":"1989","journal-title":"Am J Hum Genet."},{"key":"bibr3-04-156.1","first-page":"145","volume":"11","author":"Bergstr\u00f6m K.","year":"1977","journal-title":"Swed Dent J."},{"key":"bibr4-04-156.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4802808"},{"key":"bibr5-04-156.1","first-page":"1","volume":"100","author":"Bjerklin K.","year":"1994","journal-title":"Swed Dent J."},{"key":"bibr6-04-156.1","doi-asserted-by":"publisher","DOI":"10.3109\/00016355009087225"},{"issue":"38","key":"bibr7-04-156.1","first-page":"1","volume":"21","author":"Bohn A.","year":"1963","journal-title":"Acta Odontol Scand."},{"key":"bibr8-04-156.1","first-page":"232","volume":"3","author":"Brabant H.","year":"1961","journal-title":"Bull Group Int Rech Sci Stomatol Odontol."},{"key":"bibr9-04-156.1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ejo.a036006"},{"key":"bibr10-04-156.1","first-page":"179","volume":"32","author":"Carr G.E.","year":"1965","journal-title":"J Dent Child."},{"key":"bibr11-04-156.1","first-page":"185","volume":"16","author":"Carretero-Quezada M.G.","year":"1988","journal-title":"J Biol Buccale."},{"key":"bibr12-04-156.1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196604000-00008"},{"key":"bibr13-04-156.1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2003_040_0343_dabgqa_2.0.co_2"},{"key":"bibr14-04-156.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4802819"},{"key":"bibr15-04-156.1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2001_038_0374_hatfig_2.0.co_2"},{"key":"bibr16-04-156.1","volume-title":"\u00dcber die Genetisch Determinierte St\u00f6anf\u00e4lligkeit des Menschlichen Gebisses.","author":"Exner-Holzheidt A.","year":"1992"},{"key":"bibr17-04-156.1","first-page":"303","volume":"37","author":"Fishman L.S.","year":"1970","journal-title":"J Dent Child."},{"key":"bibr18-04-156.1","first-page":"336","volume":"22","author":"Fraser F.C.","year":"1970","journal-title":"Am J Hum Genet."},{"key":"bibr19-04-156.1","first-page":"333","volume":"10","author":"Fukuhara T.","year":"1963","journal-title":"Bull Tokyo Med Dent Univ."},{"key":"bibr20-04-156.1","first-page":"303","volume":"67","author":"Haataja J.K.","year":"1971","journal-title":"Proc Finn Dent Soc."},{"key":"bibr21-04-156.1","first-page":"240","volume":"16","author":"Heckler F.R.","year":"1979","journal-title":"Cleft Palate J."},{"key":"bibr22-04-156.1","first-page":"246","volume-title":"Lippen-Kiefer-Gaumenspalten. 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