{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:26:26Z","timestamp":1777523186482,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Twenty-four patients were evaluated to better characterize neurological and neuroradiological aspects of midline facial defects with ocular hypertelorism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After a clinical genetics evaluation, the individuals were divided into two groups: 12 isolated cases (group 1) and 12 associated with multiple congenital anomalies (group 2). The investigation protocol included medical and family history, as well as dysmorphological, neurological, and neuroradiological evaluations by magnetic resonance imaging or computed tomography scan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Because there was no significant difference concerning the neurological aspects of groups 1 and 2, they were analyzed together. Mild hypotonia (24 of 24), abnormalities in cranial shape (24 of 24), cranial nerves (19 of 24), motor coordination (18 of 24), dynamic equilibrium (14 of 24), and language problems (8 of 24) were noted. Measurements of the posterior fossa showed hypoplastic cerebellar vermis (8 of 17), the cerebellum at lower normality limits (5 of 17), and signs of cerebellar hypoplasia (3 of 7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study clearly demonstrates the presence of structural and functional neurological abnormalities related to midline facial defects with ocular hypertelorism, as well as involvement of the cerebellum. It provides a basis for future investigation of midline facial defects with ocular hypertelorism and should be considered during planning of rehabilitation treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/04-179.1","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T13:26:27Z","timestamp":1157635587000},"page":"466-470","source":"Crossref","is-referenced-by-count":4,"title":["Cerebellar Involvement in Midline Facial Defects with Ocular Hypertelorism"],"prefix":"10.1177","volume":"43","author":[{"given":"Silvyo David Ara\u00fajo","family":"Giffoni","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica M\u00e9dica, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas (UNICAMP), Campinas-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanda Maria Gimenes","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Departamento de Neurologia, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas (UNICAMP), Campinas-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f4nica Ara\u00fajo","family":"Zanardi","sequence":"additional","affiliation":[{"name":"Departamento de Radiologia, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas (UNICAMP), Campinas-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera Lucia","family":"Gil-da-Silva-Lopes","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica M\u00e9dica, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas (UNICAMP), Campinas-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,7,1]]},"reference":[{"key":"bibr1-04-179.1","volume-title":"An\u00e1lise Biom\u00e9trica e Estabelecimento de \u00cdndices de Normalidade Para o Estudo do Quarto Ventr\u00edculo Cerebral Atrav\u00e9s de Estudo por Resson\u00e2ncia Magn\u00e9tica.","author":"Abdala N.","year":"1998"},{"key":"bibr2-04-179.1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1999)8:4<226::AID-HBM6>3.0.CO;2-4"},{"key":"bibr3-04-179.1","volume-title":"Exame Neurol\u00f3gico Evolutivo da Crian\u00e7a Normal de 3 a 7 Anos de Idade: Contribui\u00e7\u00e3o Para a Avalia\u00e7\u00e3o da Fidedignidade das Provas.","author":"Bachiega M.C.M.","year":"1979"},{"key":"bibr4-04-179.1","volume-title":"Curso Pr\u00e1tico de Bioestat\u00edstica: 4 Edi\u00e7\u00e3o.","author":"Beiguelman B.","year":"1996"},{"key":"bibr5-04-179.1","unstructured":"CohenM.M.Jr, MacLeanR.E. 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