{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:52:23Z","timestamp":1790927543680,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>The 22q11.2 deletion syndrome is characterized by wide phenotypic variability, frequently involving characteristic craniofacial features, cardiac malformations, and learning difficulties. Skeletal anomalies are also common and include an obtuse angle of the cranial base, retrognathia, and cervical spine abnormalities. Despite these anomalies, sleep-disturbed breathing is not reported frequently in patients with 22q11.2 deletion syndrome. We describe a patient with an obstructive sleep disturbance that was successfully treated with a tonsillectomy followed by mandibular distraction osteogenesis. She also had central sleep apnea, initially attributed to spinal cord impingement from cervical instability. Posterior cervical fusion was associated with a decrease in the number of central apneic events.<\/jats:p>","DOI":"10.1597\/05-196","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T02:35:11Z","timestamp":1157596511000},"page":"340-346","source":"Crossref","is-referenced-by-count":23,"title":["Sleep Disturbances in 22q11.2 Deletion Syndrome: A Case with Obstructive and Central Sleep Apnea"],"prefix":"10.1177","volume":"44","author":[{"given":"Carrie L.","family":"Heike","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Craniofacial Medicine, University of Washington and Children's Hospital and Regional Medical Center, Seattle, Washington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Avellino","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington and Children's Hospital and Regional Medical Center, Seattle, 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