{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:40:33Z","timestamp":1790772033821,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To characterize the craniofacial phenotype of a mouse model for Crouzon syndrome by a quantitative analysis of skull morphology in mutant and wild-type mice and to compare the findings with skull features observed in humans with Crouzon syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      MicroCT scans and skeletal preparations were obtained on previously described Fgfr2\n                      <jats:sup>C342Y\/+<\/jats:sup>\n                      Crouzon mutant mice and wild-type mice at 6 weeks of age. Three-dimensional coordinate data from biologically relevant landmarks on the skulls were collected. Euclidean Distance Matrix Analysis was used to quantify and compare skull shapes using these landmark data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Obliteration of bilateral coronal sutures was observed in 80% of skulls, and complete synostosis of the sagittal suture was observed in 70%. In contrast, fewer than 40% of lambdoid sutures were found to be fully fused. In each of the 10 Fgfr2\n                      <jats:sup>C342Y\/+<\/jats:sup>\n                      mutant mice analyzed, the presphenoid-basisphenoid synchondrosis was fused. Skull height and width were increased in mutant mice, whereas skull length was decreased. Interorbital distance was also increased in Fgfr2\n                      <jats:sup>C342Y\/+<\/jats:sup>\n                      mice as compared with wild-type littermates. Upper-jaw length was shorter in the Fgfr2\n                      <jats:sup>C342Y\/+<\/jats:sup>\n                      mutant skulls, as was mandibular length.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Skulls of Fgfr2\n                      <jats:sup>C342Y\/+<\/jats:sup>\n                      mice differ from normal littermates in a comparable manner with differences between the skulls of humans with Crouzon syndrome and those of unaffected individuals. These findings were consistent across several regions of anatomic interest. Further investigation into the molecular mechanisms underlying the anomalies seen in the Crouzon mouse model is currently under way.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/05-212","type":"journal-article","created":{"date-parts":[[2006,4,15]],"date-time":"2006-04-15T02:33:20Z","timestamp":1145068400000},"page":"740-747","source":"Crossref","is-referenced-by-count":77,"title":["The Craniofacial Phenotype of the Crouzon Mouse: Analysis of a Model for Syndromic Craniosynostosis Using Three-Dimensional MicroCT"],"prefix":"10.1177","volume":"43","author":[{"given":"Chad A.","family":"Perlyn","sequence":"first","affiliation":[{"name":"Division of Plastic Surgery, Washington University School of Medicine, St. Louis, Missouri."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie B.","family":"DeLeon","sequence":"additional","affiliation":[{"name":"Center for Functional Anatomy and Evolution, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Babbs","sequence":"additional","affiliation":[{"name":"Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Govier","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Washington University School of Medicine, St. Louis, Missouri."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Burell","sequence":"additional","affiliation":[{"name":"Micro CT Imaging Facility, University of Utah, Salt Lake City, Utah."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tron","family":"Darvann","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Kreiborg","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Morriss-Kay","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"key":"bibr1-05-212","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.73.874.11271900"},{"key":"bibr2-05-212","first-page":"28","volume":"23","author":"Burdi A.R.","year":"1986","journal-title":"Cleft Palate J."},{"key":"bibr3-05-212","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1994_031_0201_cscaae_2.3.co_2"},{"key":"bibr4-05-212","first-page":"361","volume-title":"Craniosynostosis. Diagnosis, Evaluation, and Management.","author":"Cohen M.M.","year":"2000","edition":"2"},{"key":"bibr5-05-212","first-page":"380","volume-title":"Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis.","author":"Cohen M.M.","year":"2003"},{"key":"bibr6-05-212","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320440121"},{"key":"bibr7-05-212","first-page":"545","volume":"33","author":"Crouzon O.","year":"1912","journal-title":"Bull Soc Med Paris."},{"key":"bibr8-05-212","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2001_038_0134_teonso_2.0.co_2"},{"key":"bibr9-05-212","first-page":"40","volume":"138","author":"Devine P.","year":"1984","journal-title":"Am J Dis Child."},{"key":"bibr10-05-212","doi-asserted-by":"publisher","DOI":"10.1136\/adc.46.247.394"},{"key":"bibr11-05-212","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405031101"},{"key":"bibr12-05-212","first-page":"2659","volume":"30","author":"Ford-Hutchinson A.F.","year":"2003","journal-title":"J Rheumatol."},{"key":"bibr13-05-212","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/53.3-4.325"},{"key":"bibr14-05-212","first-page":"345","volume":"8","author":"Hartsfield J.K.","year":"1998","journal-title":"J Craniofac Genet Devel Biol."},{"key":"bibr15-05-212","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(39)91227-4"},{"issue":"18","key":"bibr16-05-212","first-page":"1","volume":"15","author":"Kreiborg S.","year":"1981","journal-title":"Scand J Plast Reconstr Surg Suppl."},{"key":"bibr17-05-212","doi-asserted-by":"publisher","DOI":"10.3109\/02844318109103433"},{"key":"bibr18-05-212","first-page":"158","volume-title":"Craniosynostosis. 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