{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:29:50Z","timestamp":1777523390282,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We report that a 4-year-old boy presented with right unilateral complete cleft lip and palate, right anophthalmos, left congenital nystagmus, absence of the vomer bone, mental-motor retardation, and normal lymphocyte karyotype (46, XY).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>For reconstruction of the deformities, we performed cleft lip repair by Millard's rotation-advancement technique and planned cleft palate repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This combination of cleft lip and palate, anophthalmos, congenital nystagmus, absent vomer bone, and mental-motor retardation has not, to our knowledge, previously been described. We suggest that this represents either another case of the rare Fryns \u201canophthalmia-plus\u201d syndrome or a new syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/06-249","type":"journal-article","created":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T12:48:13Z","timestamp":1227530893000},"page":"256-260","source":"Crossref","is-referenced-by-count":1,"title":["Anophthalmia, Cleft Lip\/Palate, Absent Vomer Bone, Nystagmus, and Mental-Motor Retardation: A New Syndrome or Fryns\u201cAnophthalmia-Plus\u201d Syndrome?"],"prefix":"10.1177","volume":"45","author":[{"given":"Derya","family":"\u00d6z\u00e7elik","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive, and Aesthetic Surgery, D\u00fczce University, D\u00fczce Medical Faculty, D\u00fczce, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim","family":"Sa\u011flam","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, D\u00fczce University, D\u00fczce Medical Faculty, D\u00fczce, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"S\u0131lan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, D\u00fczce University, D\u00fczce Medical Faculty, D\u00fczce, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclbin","family":"Sezen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, D\u00fczce University, D\u00fczce Medical Faculty, D\u00fczce, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toygar","family":"\u00dcnveren","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, and Aesthetic Surgery, D\u00fczce University, D\u00fczce Medical Faculty, D\u00fczce, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"bibr1-06-249","first-page":"145","volume":"16","author":"Akalin I.","year":"2005","journal-title":"Genet Couns."},{"key":"bibr2-06-249","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1981.tb00695.x"},{"key":"bibr3-06-249","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320580204"},{"key":"bibr4-06-249","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320500108"},{"key":"bibr5-06-249","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31566"},{"key":"bibr6-06-249","first-page":"2627","volume-title":"Plastic Surgery.","author":"Millard R.","year":"1990"},{"key":"bibr7-06-249","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470523"},{"key":"bibr8-06-249","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051180"},{"key":"bibr9-06-249","doi-asserted-by":"publisher","DOI":"10.1097\/00019605-199507000-00010"},{"key":"bibr10-06-249","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20232"},{"key":"bibr11-06-249","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(76)80013-6"},{"key":"bibr12-06-249","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971128)73:1<36::AID-AJMG8>3.0.CO;2-N"},{"key":"bibr13-06-249","doi-asserted-by":"publisher","DOI":"10.1097\/00019605-200301000-00007"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/06-249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/06-249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:20:44Z","timestamp":1777393244000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1597\/06-249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1597\/06-249"],"URL":"https:\/\/doi.org\/10.1597\/06-249","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}