{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:37:44Z","timestamp":1790883464697,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate longitudinally the effect of infant orthopedics (IO) on dentofacial cephalometric variables in unilateral cleft lip and palate (UCLP) patients from 4 to 6 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective two-arm randomized controlled clinical trial in three cleft palate centers in The Netherlands (Dutchcleft trial).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>Fifty-four children with complete UCLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>Patients were divided randomly into two groups. Half of the patients (IO+) had IO until surgical closure of the soft palate at the age of \u00b152 weeks; the other half (IO\u2212) received no intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Mean Outcome Measures:<\/jats:title>\n                    <jats:p>Cephalometric values representing soft tissue, hard tissue, and dental structures, measured on lateral headfilms made at 4 and 6 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the IO+ group, 21 patients were analyzed; in the IO\u2212 group, 20 patients were analyzed at age 4 and 22 at age 6. No differences were found between IO+ and IO\u2212, except for two measurements: The interincisal angle was larger and the mentolabial angle was smaller in the IO+ group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>For infants with UCLP whose surgical management included soft palate repair at 12 months and delayed hard palate closure, cephalometric outcomes at ages 4 and 6 provide no indication for the type of IO used in this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/08-034.1","type":"journal-article","created":{"date-parts":[[2009,11,10]],"date-time":"2009-11-10T15:19:14Z","timestamp":1257866354000},"page":"654-663","source":"Crossref","is-referenced-by-count":58,"title":["Infant Orthopedics and Facial Growth in Complete Unilateral Cleft Lip and Palate until Six Years of Age (Dutchcleft)"],"prefix":"10.1177","volume":"46","author":[{"given":"Catharina A. M.","family":"Bongaarts","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Center, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Prahl-Andersen","sequence":"additional","affiliation":[{"name":"Academic Center of Dentistry Amsterdam, and Former Head of the Department of Orthodontics, Erasmus MC University Medical Center Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewald M.","family":"Bronkhorst","sequence":"additional","affiliation":[{"name":"Department of Preventive and Curative Dentistry, Radboud University NijmegenMedical Center, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Prahl","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Ongkosuwito","sequence":"additional","affiliation":[{"name":"Craniofacial Center Rotterdam, Erasmus Medical Center, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfred A.","family":"Borstlap","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Kuijpers-Jagtman","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Oral Biology, and Head of the Cleft Palate Craniofacial Unit, Radboud University Nijmegen Medical Center, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,11,1]]},"reference":[{"key":"bibr1-08-034.1","first-page":"104","volume":"4","author":"Atherton J.D.","year":"1967","journal-title":"Cleft Pal J."},{"key":"bibr2-08-034.1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(71)90028-5"},{"key":"bibr3-08-034.1","doi-asserted-by":"publisher","DOI":"10.1597\/03-051.1"},{"key":"bibr4-08-034.1","doi-asserted-by":"publisher","DOI":"10.1597\/07-043.1"},{"key":"bibr5-08-034.1","doi-asserted-by":"publisher","DOI":"10.1597\/05-129"},{"key":"bibr6-08-034.1","doi-asserted-by":"publisher","DOI":"10.1597\/06-236.1"},{"key":"bibr7-08-034.1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200309000-00018"},{"issue":"57","key":"bibr8-08-034.1","first-page":"11","volume":"28","author":"Dahl E.","year":"1970","journal-title":"Acta Odontol 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