{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:14:58Z","timestamp":1784693698731,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the microbial etiology of suppurative chronic otitis media (SCOM) in patients with complete cleft lip and palate and isolated cleft palate and to determine the sensitivity of isolated microorganisms to antibiotics by drug diffusion from impregnated discs in agar and the minimum inhibitory concentration of each drug to these microorganisms by drug dilution in agar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Patients:<\/jats:title>\n                    <jats:p>Effusion samples of SCOM obtained from 40 patients with cleft lip and palate registered at the Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, at Bauru, Brazil, were bacteriologically analyzed by cultures. The isolated bacteria were submitted to an in vitro susceptibility test to clinically used drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Positive cultures were obtained in 100% of studied cases. Among the 57 strains observed, the most frequent were Pseudomonas aeruginosa (35%), Staphylococcus aureus (15.5%), Enterococcus faecalis (14%), and Proteus mirabilis (12%). The frequency of Gram-negative bacilli (enterobacteriaceae and nonfermentative bacilli) was 67%. Pseudomonas aeruginosa presented the highest sensitivity to ciprofloxacin, and enterobacteriaceae exhibited the highest sensitivity to gentamicin. The strains of S. aureus and E. faecalis presented the highest sensitivity to imipenem and sulfamethoxazole\/trimethoprim, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients with cleft lip and palate presenting with SCOM exhibited 100% positive cultures, with the highest frequency of Pseudomonas and enterobacteriaceae. With regard to the action of antibiotics, imipenem was effective against the four species of isolated microorganisms, followed by ciprofloxacin, which was effective against 75% of isolated species.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/08-144.1","type":"journal-article","created":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T14:33:33Z","timestamp":1251902013000},"page":"461-467","source":"Crossref","is-referenced-by-count":16,"title":["Chronic Suppurative Otitis Media in Cleft Palate: Microorganism Etiology and Susceptibilities"],"prefix":"10.1177","volume":"46","author":[{"given":"Paulo Henrique","family":"Weckwerth","sequence":"first","affiliation":[{"name":"University of Sagrado Cora\u00e7\u00e3o, Bauru, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"de Magalh\u00e3es Lopes","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University \u201cJulio de Mesquita Filho,\u201d Botucatu, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio H\u00fangaro","family":"Duarte","sequence":"additional","affiliation":[{"name":"University of Sagrado Cora\u00e7\u00e3o, Bauru, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Villas B\u00f4as","family":"Weckwerth","sequence":"additional","affiliation":[{"name":"Scientific Investigator, Sector of Microbiology, Institute Lauro de Souza Lima, Bauru, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Henrique Ferreira","family":"Martins","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingos Lam\u00f4nica","family":"Neto","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder Fernandes","family":"de Aguiar","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"bibr1-08-144.1","volume-title":"Bailey and Scott's Diagnostic Microbiology.","author":"Baron E.J.","year":"1994","edition":"9"},{"key":"bibr2-08-144.1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90168-6"},{"key":"bibr3-08-144.1","first-page":"195","volume-title":"Ortodontia para fonoaudiologia.","author":"Capelozza Filho L.","year":"1994"},{"key":"bibr4-08-144.1","first-page":"233","volume":"78","author":"Capelozza Filho L.","year":"1988","journal-title":"Rev Bras Cir."},{"key":"bibr5-08-144.1","first-page":"220","volume":"61","author":"Carvalho 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