{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:06:25Z","timestamp":1777521985717,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>We present a patient with hemifacial microsomia and immune deficiency. The patient is a 5-year-old with grade III microtia and Pruzansky type I right mandibular hypoplasia. She developed 25 pulmonary infections in 3 years, required hospitalization every 6 weeks to receive antibiotics, and experienced recurrent herpes stomatitis and esophagitis, staphylococcal bacteremia, urinary tract, sinus, and ear infections. She had low total IgG, IgG1, IgG2, IgA, and anti-pneumococcal antibody levels. She was unable to maintain protective pneumococcal titers following vaccination. The patient's 7-year-old sister also suffered from recurrent infections, had a left facial skin tag, and a left arachnoid cyst. We conclude that immune deficiency can occur in association with hemifacial microsomia.<\/jats:p>","DOI":"10.1597\/08-169.1","type":"journal-article","created":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T14:33:33Z","timestamp":1251902013000},"page":"477-480","source":"Crossref","is-referenced-by-count":1,"title":["Humoral Immune Deficiency and Hemifacial Microsomia Seen in One Family"],"prefix":"10.1177","volume":"46","author":[{"given":"Zamaneh","family":"Mikhak","sequence":"first","affiliation":[{"name":"Harvard Medical School, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Mulliken","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Department of Plastic Surgery, Children's Hospital, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children's Hospital, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco A.","family":"Bonilla","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Clinical Immunology, Division of Immunology, Children's Hospital, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia E.","family":"Kimonis","sequence":"additional","affiliation":[{"name":"University of California Irvine Medical Center, Division of Genetics and Metabolism, Department of Pediatrics, Orange, California."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"bibr1-08-169.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31290"},{"key":"bibr2-08-169.1","first-page":"276","volume":"26","author":"Cohen M.M.","year":"1989","journal-title":"Cleft Palate J."},{"key":"bibr3-08-169.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.10.006"},{"key":"bibr4-08-169.1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.02088.x"},{"key":"bibr5-08-169.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(63)80233-4"},{"key":"bibr6-08-169.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81137-0"},{"key":"bibr7-08-169.1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2005.012"},{"key":"bibr8-08-169.1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1995_032_0405_opaoca_2.3.co_2"},{"key":"bibr9-08-169.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320430602"},{"key":"bibr10-08-169.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-0128(98)00023-2"},{"key":"bibr11-08-169.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10983"},{"key":"bibr12-08-169.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320150207"},{"key":"bibr13-08-169.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260215"},{"key":"bibr14-08-169.1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199506000-00023"},{"key":"bibr15-08-169.1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980724)78:4<345::AID-AJMG8>3.0.CO;2-K"},{"key":"bibr16-08-169.1","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0b013e328010d313"},{"key":"bibr17-08-169.1","doi-asserted-by":"publisher","DOI":"10.1597\/03-110.1"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/08-169.1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/08-169.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:15:58Z","timestamp":1777392958000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1597\/08-169.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1597\/08-169.1"],"URL":"https:\/\/doi.org\/10.1597\/08-169.1","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}