{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T20:27:17Z","timestamp":1781382437103,"version":"3.54.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine mortality rate and cause of death in infants born with orofacial clefts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case note review of all children with orofacial clefts within the East of England Cleft Network who have died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 2002 and 2010, of 638 children born with orofacial clefts, 23 died at a median age of 5 months (range, 1 day to 4 years). The overall mortality rate was 36 per 1000 cleft births. A total of 21 deaths were in the isolated cleft palate group, with a calculated death rate of 68.1 per 1000. One child each from the cleft lip and the cleft lip and palate groups died. Of the children who died, 21 (91%) had other structural abnormalities. Of these children, 19 (83%) died before their first birthday. The causes of death were mainly due to associated congenital anomalies (61%) and infection (17%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children born with cleft palate have a 15-fold increase in mortality compared with the regional East of England infant mortality rate and at least a 10-fold increase when compared with other clefts. Pediatricians should be involved in the care of these complicated patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/10-179","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T16:50:03Z","timestamp":1311353403000},"page":"508-511","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Mortality among Infants Born with Orofacial Clefts in a Single Cleft Network"],"prefix":"10.1177","volume":"49","author":[{"given":"Sok-Leng","family":"Kang","sequence":"first","affiliation":[{"name":"Basildon Hospital, Essex, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidambara Subramanian","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Watford General Hospital, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilf","family":"Kelsall","sequence":"additional","affiliation":[{"name":"Addenbrookes Hospital, Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"bibr1-10-179","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38106.559120.7C"},{"key":"bibr2-10-179","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200011)20:11<870::AID-PD940>3.0.CO;2-J"},{"key":"bibr3-10-179","volume-title":"Cleft Lip and\/or Palate. Report of a CSAG Committee.","author":"Clinical Standards Advisory Group (CSAG).","year":"1998"},{"key":"bibr4-10-179","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6447"},{"key":"bibr5-10-179","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70577-6"},{"key":"bibr6-10-179","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1992_029_0451_fymaiw_2.3.co_2"},{"key":"bibr7-10-179","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7472"},{"key":"bibr8-10-179","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60695-4"},{"key":"bibr9-10-179","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500072854"},{"key":"bibr10-10-179","unstructured":"Northamptonshire Observatory. Live births by usual residence area of mother. Data subset: 2002\u20132009. Extracted from http:\/\/www.northamptonshireobservatory.org.uk\/. Accessed June 17, 2011."},{"key":"bibr11-10-179","unstructured":"Office for National Statistics. Infant and perinatal mortality 2006: health areas, England and Wales. Health Stat Q. 2007: 35. Available at http:\/\/www.statistics.gov.uk\/downloads\/theme_health\/Infant_and_perinatal_report_HSQ35.pdf. Accessed November 5, 2010."},{"key":"bibr12-10-179","unstructured":"Office for National Statistics. Mortality statistics: childhood, infant and perinatal 2007. Review of the National Statistician on deaths in England and Wales, 2007. Series DH3 No. 40. Available at http:\/\/www.statistics.gov.uk\/downloads\/theme_health\/DH3_40_2007\/DH3_40_2007.pdf Accessed June 17, 2011."},{"key":"bibr13-10-179","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.177089"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/10-179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1597\/10-179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/10-179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:17:06Z","timestamp":1777393026000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1597\/10-179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1597\/10-179"],"URL":"https:\/\/doi.org\/10.1597\/10-179","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}