{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:26:23Z","timestamp":1791066383788,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Individuals with oral clefts exhibit considerably more dental anomalies than do individuals without clefts. Our aim was to evaluate the prevalence of tooth agenesis in a sample composed of 124 children (81 boys and 43 girls, mean age 12.5 years) with clefts registered with the Cleft Palate Center in Strasbourg (France).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cleft types and dental agenesis were assessed by clinical and radiographic examination. Cleft types were divided into four groups according to the clinical extent of the cleft (cleft lip only [CL, 12.9%], cleft lip and alveolus [CLA, 4%], cleft lip and palate [CLP, 49.2%], and cleft palate only [CP, 33.9%]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the subjects 63% had evidence of hypodontia: maxillary lateral incisors (54%) and upper and lower premolars (32%) were the most common missing teeth. The number of dental ageneses associated with CP (54%) and CLP (79%) was significantly higher than that with CL (33%). All these anomalies were found in proportionately higher frequencies as the severity of the cleft increased, and we found left side predominance for hypodontia (p &lt; .01) irrespective of cleft sidedness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both right-sided and left-sided clefts were more frequently correlated with left-sided dental agenesis. This left-sided prevalence suggests that common signaling malfunctions might be involved, both in dental development anomalies and cleft genesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/11-025","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T21:50:22Z","timestamp":1315605022000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Left-Sided Predominance of Hypodontia Irrespective of Cleft Sidedness in a French Population"],"prefix":"10.1177","volume":"49","author":[{"given":"Olivier","family":"Matern","sequence":"first","affiliation":[{"name":"P\u00f4le de M\u00e9decine et Chirurgie bucco-dentaires, Unit\u00e9 Fonctionnelle d'Orthop\u00e9die Dento-Faciale, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik-Andr\u00e9","family":"Sauleau","sequence":"additional","affiliation":[{"name":"P\u00f4le de M\u00e9decine et Chirurgie bucco-dentaires, Unit\u00e9 Fonctionnelle d'Orthop\u00e9die Dento-Faciale, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Tschill","sequence":"additional","affiliation":[{"name":"P\u00f4le de M\u00e9decine et Chirurgie bucco-dentaires, Unit\u00e9 Fonctionnelle d'Orthop\u00e9die Dento-Faciale, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Perrin-Schmitt","sequence":"additional","affiliation":[{"name":"UDS-Facult\u00e9 de M\u00e9decine, UMR977-INSERM, Laboratoire de Biochimie G\u00e9n\u00e9rale-NHC-CHRU, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Grollemund","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaires, D\u00e9partement de Sant\u00e9 Publique, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"bibr1-11-025","doi-asserted-by":"publisher","DOI":"10.1597\/03-126.1"},{"key":"bibr2-11-025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2009.00698.x"},{"key":"bibr3-11-025","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10171"},{"key":"bibr4-11-025","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2003_040_0343_dabgqa_2.0.co_2"},{"key":"bibr5-11-025","unstructured":"GraberT.M., VanarsdallR.L., BigK.W.L. Orthodontics: Current Principles and Techniques. 4th ed. St. Louis: Elsevier; 2005: 109\u2013110."},{"key":"bibr6-11-025","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2005.02.029"},{"key":"bibr7-11-025","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20295"},{"key":"bibr8-11-025","doi-asserted-by":"publisher","DOI":"10.1597\/09-159"},{"key":"bibr9-11-025","doi-asserted-by":"publisher","DOI":"10.1080\/02844319850158813"},{"key":"bibr10-11-025","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601013"},{"key":"bibr11-11-025","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100410"},{"key":"bibr12-11-025","doi-asserted-by":"publisher","DOI":"10.1597\/07-064.1"},{"key":"bibr13-11-025","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81472-5"},{"key":"bibr14-11-025","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.779"},{"key":"bibr15-11-025","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5426.403"},{"key":"bibr16-11-025","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500612"},{"key":"bibr17-11-025","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.57182"},{"key":"bibr18-11-025","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.01.031"},{"key":"bibr19-11-025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00158.x"},{"key":"bibr20-11-025","first-page":"234","volume":"16","author":"Robert E.","year":"1996","journal-title":"J Craniofac Genet Dev Biol."},{"key":"bibr21-11-025","doi-asserted-by":"publisher","DOI":"10.1038\/ng0494-348"},{"key":"bibr22-11-025","first-page":"16","volume":"70","author":"Shapira Y.","year":"2000","journal-title":"Angle Orthod."},{"key":"bibr23-11-025","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2003_040_0274_gasocl_2.0.co_2"},{"key":"bibr24-11-025","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh052"},{"key":"bibr25-11-025","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1992_029_0380_mliosw_2.3.co_2"},{"key":"bibr26-11-025","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-417"},{"key":"bibr27-11-025","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181833793"},{"key":"bibr28-11-025","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300913"},{"key":"bibr29-11-025","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31620"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/11-025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1597\/11-025","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/11-025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:17:02Z","timestamp":1777393022000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1597\/11-025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1597\/11-025"],"URL":"https:\/\/doi.org\/10.1597\/11-025","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}