{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:15:45Z","timestamp":1777522545423,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between the TGFA:c.3851T &gt; C (rs11466285) and TGFA:c.3822G &gt; A (rs3771523) single-nucleotide polymorphisms (SNPs) and nonsyndromic cleft lip and\/or cleft palate (CL\/P) with microarray in north China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Setting<\/jats:title>\n                    <jats:p>Test association by both case-control and case-parent analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Two SNPs of 150 controls, 166 cases, and 271 of their parents were genotyped using microarray based on the allele-specific primer extension, and chi-square statistics and family-based association test analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both sequencing and microarray analysis produced identical results. We found significant evidence of overtransmission of the C allele of c.3851 T &gt; C and the A allele of C.3822G &gt; A in case-parent trios for CL\/P but not for cleft palate only (CP). Significant differences for both genotypic and allelic distributions between cases and controls were found at C.3822G &gt; A and c.3851 T &gt; C for CL\/P but not for CP. The TGFA [C; G] and [T; A] haplotypes showed significant overtransmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results support that two SNPs are associated with nonsyndromic CL\/P but not for CP in northern Chinese populations. It was demonstrated that this microarray is suitable to test SNPs associated with nonsyndromic CL\/P.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/12-145","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T14:10:20Z","timestamp":1370527820000},"page":"486-492","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Microarray Analysis of Two Single-Nucleotide Polymorphisms of Transforming Growth Factor Alpha in Patients with Nonsyndromic Cleft of North China"],"prefix":"10.1177","volume":"51","author":[{"given":"Wei","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory of Reproductive Health of Liaoning, Shenyang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weitian","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Health of Liaoning, Shenyang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongping","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Health of Liaoning, Shenyang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Stomatology, China Medical University, Shenyang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengjian","family":"Li","sequence":"additional","affiliation":[{"name":"School of Stomatology, China Medical University, Shenyang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Louisiana State University Health Science Center, Shreveport, Louisiana."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Stomatology, China Medical University, Shenyang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Li","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Research Institute of Family Planning, Shenyang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,7,1]]},"reference":[{"key":"bibr1-12-145","first-page":"348","volume":"5","author":"Ardinger H.H.","year":"1989","journal-title":"Am J Hum 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