{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:40:14Z","timestamp":1790073614889,"version":"4.0.1"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal of this study was to evaluate the craniofacial morphology at 5 and 10 years of age and at the completion of growth, the need for final orthognathic surgery, and the orthodontic burden in a sample of patients with unilateral cleft lip and palate consecutively treated by the same surgeon with the same two-step protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A sample of 62 adult patients with unilateral cleft lip and palate was retrospectively collected (mean age, 17.5 years). Lateral cephalograms at three time points were traced. The need for orthognathic surgery was assessed, subdividing the sample into an orthognathic surgery group and nonorthognathic surgery group. Time and modality of orthodontic treatment were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cephalometric values related to maxillary growth (SNA, SNAns) and maxillomandibular relation (ANB, NAPg) were significantly different between the two groups already at 5 and 10 years of age. All patients presenting an ANB smaller than 2\u00b0 at 5 years needed a Le Fort I osteotomy. Mandibular protrusion (SNB, SNPg) was not different at 5 and 10 years, but was different at the completion of growth. Patients with the same initial maxillomandibular relation did not show better growth when subjected to earlier or longer orthodontic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients needing final jaw surgery had a more severe skeletal discrepancy during early childhood. The ANB angle at 5 years allowed doctors to identify 45% of the need for orthognathic surgery. The final craniofacial pattern does not seem to change significantly with early or prolonged orthodontic treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/12-211","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T16:49:46Z","timestamp":1374598186000},"page":"688-697","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":50,"title":["Long-Term Follow-Up of UCLP Patients: Surgical and Orthodontic Burden of Care during Growth and Final Orthognathic Surgery Need"],"prefix":"10.1177","volume":"52","author":[{"given":"Maria Costanza","family":"Meazzini","sequence":"first","affiliation":[{"name":"Regional Center for Cleft Lip and Palate, Smile House, Department of Maxillofacial Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Varacca","family":"Capello","sequence":"additional","affiliation":[{"name":"Orthodontics, Department of Orthodontics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ventrini","sequence":"additional","affiliation":[{"name":"Orthodontics, Department of Orthodontics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Autelitano","sequence":"additional","affiliation":[{"name":"Cleft Lip and Palate Unit, Regional Center for Cleft Lip and Palate, Smile House, Department of Maxillofacial Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Morabito","sequence":"additional","affiliation":[{"name":"Department of Biomedical Statistics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Garattini","sequence":"additional","affiliation":[{"name":"Orthodontics, Department of Orthodontics, Smile House"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Brusati","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery, Regional Center for Cleft Lip and Palate, Smile House, Department of Maxillofacial Surgery, San Paolo Hospital, University of Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"bibr1-12-211","first-page":"316","volume":"72","author":"Baccetti T.","year":"2002","journal-title":"Angle Orthod."},{"key":"bibr2-12-211","doi-asserted-by":"publisher","DOI":"10.3109\/02844319209035185"},{"key":"bibr3-12-211","volume-title":"Statistical Power Analysis of the Behavioral Sciences.","author":"Cohen J.","year":"1988","edition":"2"},{"key":"bibr4-12-211","volume-title":"Statistical Methods for Medical and Biological Students.","author":"Dahlberg G.","year":"1940"},{"key":"bibr5-12-211","doi-asserted-by":"publisher","DOI":"10.1597\/08-176.1"},{"key":"bibr6-12-211","first-page":"121","volume-title":"Il trattamento chirurgico e ortodontico della labio-palatoschisi: La ricostruzione dell' equilibrio funzionale.","author":"Delaire J.","year":"1989"},{"key":"bibr7-12-211","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1990_027_0354_eoucla_2.3.co_2"},{"key":"bibr8-12-211","doi-asserted-by":"publisher","DOI":"10.1597\/04-093.1"},{"key":"bibr9-12-211","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.03.020"},{"key":"bibr10-12-211","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2000_037_0533_ototpw_2.0.co_2"},{"key":"bibr11-12-211","doi-asserted-by":"publisher","DOI":"10.1597\/07-098.1"},{"key":"bibr12-12-211","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2009.06.001"},{"key":"bibr13-12-211","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000256064.74938.72"},{"key":"bibr14-12-211","doi-asserted-by":"publisher","DOI":"10.3109\/2000656X.2011.583493"},{"key":"bibr15-12-211","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2007.09.168"},{"key":"bibr16-12-211","doi-asserted-by":"publisher","DOI":"10.1597\/06-053.1"},{"key":"bibr17-12-211","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2003_040_0337_arpcto_2.0.co_2"},{"key":"bibr18-12-211","first-page":"5","volume":"24","author":"Ross R.B.","year":"1987","journal-title":"Cleft Palate J."},{"key":"bibr19-12-211","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1991_028_0001_asofgi_2.3.co_2"},{"key":"bibr20-12-211","first-page":"28","volume-title":"Facial Clefts and Craniosynostosis. 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