{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:15:02Z","timestamp":1777522502256,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Many types of soft tissue grafts have been used for the reconstruction of oral mucosal defects. The best results are achieved with mucosal grafts; however, when large areas must be grafted, sufficient donor tissue is not available. Tissue engineering represents an alternative method to obtain sufficient autologous tissue for reconstructing oral wounds. Herein we present a pediatric patient with hemifacial microsomia and congenital ankyloglossia requiring multiple surgical interventions, and in which an autologous full-thickness tissue-engineered oral mucosa was used for successful oral reconstruction. Our study demonstrates that even under challenging conditions, robust tissue-engineered products, such as the fibrin-based oral mucosa described here, can achieve successful tissue regeneration.<\/jats:p>","DOI":"10.1597\/12-245","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T16:49:46Z","timestamp":1374598186000},"page":"246-251","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Tissue-Engineered Oral Mucosa for Mucosal Reconstruction in a Pediatric Patient with Hemifacial Microsomia and Ankyloglossia"],"prefix":"10.1177","volume":"51","author":[{"given":"Sara","family":"Llames","sequence":"first","affiliation":[{"name":"Tissue Engineering Unit, Centro Comunitario de Sangre y Tejidos del Principado de Asturias, Oviedo, Spain. Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER U714), Oviedo, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Recuero","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgeons, Oral and Maxillofacial Surgery Department, Hospital Universitario 12 de Octobre, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Romance","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgeons, Oral and Maxillofacial Surgery Department, Hospital Universitario 12 de Octobre, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Tissue Engineering Unit, Centro Comunitario de Sangre y Tejidos del Principado de Asturias, Oviedo, Spain, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER U714), Oviedo, Spain, Bioengineering Department, Universidad Carlos III, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Department, Hospital Universitario Central de Asturias, Oviedo, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro Fern\u00e1ndez","family":"Del Valle","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Department, Hospital Universitario Central de Asturias, Oviedo, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Meana","sequence":"additional","affiliation":[{"name":"Tissue Engineering Unit, Centro Comunitario de Sangre y Tejidos del Principado de Asturias, Oviedo, Spain, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER U714), Oviedo, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Larcher","sequence":"additional","affiliation":[{"name":"Bioengineering Department, Universidad Carlos III, Madrid, Spain, Epithelial Biomedicine Division, CIEMAT, Madrid, Spain, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER U714), Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Del R\u00edo","sequence":"additional","affiliation":[{"name":"Universidad Carlos III, Madrid, Spain, Epithelial Biomedicine Division, CIEMAT, Madrid, Spain. 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