{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:17:17Z","timestamp":1777522637817,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this work was to fine-map the region 6q23.1, which obtained suggestive linkage signal (logarithm of the odds [LOD] score = 2.22 under a recessive model) to cleft lip with or without cleft palate (CL\u00b1P) in our previous genome-wide linkage scan to identify possible genetic variants that may contribute to CL\u00b1P.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We used densely spaced markers spanning the entire 6q23.1 region to test for association with CL\u00b1P in a family cohort sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Clinical information and DNA samples were obtained from families in the Philippines at their homes or primary health care clinics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The study sample consisted of 477 subjects (224 females and 253 males), segregating isolated CL\u00b1P, from 72 living in the same area in the Philippines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure<\/jats:title>\n                    <jats:p>Overtransmission of alleles to persons born with CL\u00b1P.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found statistical evidence of association between a marker of TULP4 (rs651333) with CL\u00b1P ( P = .00007).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results further support the linkage results for the chromosome 6q region and reveal a novel candidate gene for CL\u00b1P.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/13-023","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T14:17:02Z","timestamp":1380118622000},"page":"128-134","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Fine Mapping of 6q23.1 Identifies\n                    <i>TULP4<\/i>\n                    as Contributing to Clefts"],"prefix":"10.1177","volume":"52","author":[{"given":"Alexandre R.","family":"Vieira","sequence":"first","affiliation":[{"name":"Department of Oral Biology and Center for Craniofacial and Dental Genetics and Department of Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia M.","family":"De Carvalho","sequence":"additional","affiliation":[{"name":"Department of Genetics, Institute of Biology, Center of Health Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Johnson","sequence":"additional","affiliation":[{"name":"Health Information Management, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"DeVos","sequence":"additional","affiliation":[{"name":"Department of Oral Biology; School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa L.","family":"Swailes","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dental Medicine, and Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan L.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Deeley","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"bibr1-13-023","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1203"},{"key":"bibr2-13-023","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"bibr3-13-023","first-page":"469","volume":"35","author":"Beaty T.H.","year":"2011","journal-title":"Genet Epidemiol."},{"key":"bibr4-13-023","doi-asserted-by":"publisher","DOI":"10.1086\/381000"},{"key":"bibr5-13-023","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn186"},{"key":"bibr6-13-023","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.08.004"},{"key":"bibr7-13-023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.06.020"},{"key":"bibr8-13-023","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20461"},{"key":"bibr9-13-023","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2004.11.011"},{"key":"bibr10-13-023","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970627)70:4<377::AID-AJMG9>3.0.CO;2-Q"},{"key":"bibr11-13-023","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200625"},{"key":"bibr12-13-023","doi-asserted-by":"publisher","DOI":"10.1038\/nature02168"},{"key":"bibr13-13-023","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242009000100006"},{"key":"bibr14-13-023","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510370004"},{"key":"bibr15-13-023","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000185138.65820.7f"},{"key":"bibr16-13-023","doi-asserted-by":"publisher","DOI":"10.1038\/ng.506"},{"key":"bibr17-13-023","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(03)00138-X"},{"key":"bibr18-13-023","doi-asserted-by":"publisher","DOI":"10.1086\/422475"},{"key":"bibr19-13-023","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-225"},{"key":"bibr20-13-023","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1997_034_0007_caesoc_2.3.co_2"},{"key":"bibr21-13-023","doi-asserted-by":"publisher","DOI":"10.1086\/301904"},{"key":"bibr22-13-023","unstructured":"Philippine Daily Inquirer.\n                      More Filipino women beer drinkers than men, says Radio Veritas study. October 22, 2012. Available at http:\/\/newsinfo.inquirer.net\/293788\/more-filipino-women-beer-drinkers-than-men-says-radio-veritas-study. Accessed February 4, 2013."},{"key":"bibr23-13-023","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1101\/gr.157801","volume":"11","author":"Ranade K.","year":"2001","journal-title":"Genome Res."},{"key":"bibr24-13-023","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn325"},{"key":"bibr25-13-023","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32295"},{"key":"bibr26-13-023","unstructured":"World Health Organization. World Health Statistics 2012. Geneva, Switzerland: World Health Organization; 2012. Available at http:\/\/www.who.int\/gho\/publications\/world_health_statistics\/EN_WHS2012_Full.pdf. 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