{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:20:14Z","timestamp":1787023214314,"version":"build-2736575974"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study explored posterior nasopharyngeal augmentation with an acellular dermal matrix sheeting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Evaluation of the persistence and safety of a submucosal implant of rolled acellular dermis over a 3-month period in a piglet model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Institute Hills Facility, part of the Mayo Clinic Rochester health care facility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Fifteen 5-week-old domestic piglets of unspecified gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Twelve piglets were implanted at age 5 weeks with a rolled sheet of acellular dermal matrix (Strattice). Implants were inserted in a submucosal pocket in the soft palate. Three piglets underwent sham operations, with creation of submucosal pockets without implantation. After a 3-month observation period, the palates were harvested for evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Grossly, persistence of bulk at the surgical site in 5 of the 12 implanted piglets was noted at 3 months. Histologically, no persistence of the dermal matrix could be observed. Incorporation and\/or resorption of the dermal matrix occurred with minimal to no host inflammatory response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This experiment demonstrated the safety of a rolled acellular dermal implant in a submucosal location in a pig model, without surgical complication, host inflammatory reaction, or rejection. Minimal, if any, bulk of the implant persisted in the implanted location after 3 months. Although acellular dermal matrix sheeting appears to be safe and well-tolerated, it does not offer a long-term treatment option for posterior pharyngeal augmentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/13-158","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T17:03:06Z","timestamp":1393347786000},"page":"198-202","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["In Vivo Durability and Safety of Rolled Acellular Dermis in a Submucosal Pocket in Pigs"],"prefix":"10.1177","volume":"52","author":[{"given":"Ashley G.","family":"O'reilly","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin J.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelagh A.","family":"Cofer","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"bibr1-13-158","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.110"},{"key":"bibr2-13-158","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2004.03.013"},{"key":"bibr3-13-158","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200112000-00015"},{"key":"bibr4-13-158","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3181c1fec6"},{"key":"bibr5-13-158","first-page":"771","volume":"23","author":"Passavant G.","year":"1879","journal-title":"Arch Klin Chir."},{"key":"bibr6-13-158","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.3.2.101"},{"key":"bibr7-13-158","doi-asserted-by":"publisher","DOI":"10.1177\/000348947708600417"},{"key":"bibr8-13-158","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)32341-5"},{"key":"bibr9-13-158","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000279523.58632.0f"},{"key":"bibr10-13-158","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1993_030_0387_osasts_2.3.co_2"},{"key":"bibr11-13-158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.06.010"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/13-158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1597\/13-158","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1597\/13-158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:18:17Z","timestamp":1777393097000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1597\/13-158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1597\/13-158"],"URL":"https:\/\/doi.org\/10.1597\/13-158","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}