{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:17:52Z","timestamp":1777522672117,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to describe the orofacial features of 26 unrelated Brazilian patients with mucopolysaccharidosis and to verify any possible associations between these findings and specific types of mucopolysaccharidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were diagnosed with mucopolysaccharidosis and clinically evaluated. Following consent, a clinical assessment form was completed. Facial and intraoral examination was performed by evaluating facial pattern, malocclusions, dental caries, and tooth identification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Midface deficiency, increased lower facial third, anterior open bite, convex profile, macroglossia, gingival enlargement, and spaced arches were the most frequently observed features. These findings did not allow a differential diagnosis among the different types of mucopolysaccharidosis, except for pitting enamel, which significantly associated with mucopolysaccharidosis IVA ( P &lt; .001). Open bite was associated with mucopolysaccharidosis types I, II, III, and VI; however, only one patient with mucopolysaccharidosis IVA expressed this feature ( P = .043).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that pitted enamel in patients with mucopolysaccharidosis is most likely a feature of mucopolysaccharidosis type IVA; whereas, open bite is rarely observed in these patients. Orofacial features in mucopolysaccharidosis may help pediatric dentists recognize this disorder and minimize the delay between the initial signs\/symptoms and diagnosis of the disease. Future studies should focus on the longitudinal manifestations, expression, and severity of mucopolysaccharidosis-associated orofacial anomalies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/13-204","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T15:43:04Z","timestamp":1402501384000},"page":"352-358","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["A Clinical Multicenter Study of Orofacial Features in 26 Brazilian Patients with Different Types of Mucopolysaccharidosis"],"prefix":"10.1177","volume":"52","author":[{"given":"Erlane Marques","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane S.R.","family":"Fonteles","sequence":"additional","affiliation":[{"name":"Pediatric Dental Unit, Special Care Clinic, Postgraduate Program\u2013Dentistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Bezerra","family":"Freitas","sequence":"additional","affiliation":[{"name":"Pediatric Dental Unit, Special Care Clinic, Postgraduate Program\u2013Dentistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla Shangela","family":"Da Silva Alves","sequence":"additional","affiliation":[{"name":"Dentistry, Department of Clinical Dentistry, Federal University of Cear\u00e1, Fortaleza, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Jalles","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Statistics and Applied Mathematics, Federal University of Cear\u00e1, Fortaleza, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Ant\u00f4nio","family":"Bruno Da Silva","sequence":"additional","affiliation":[{"name":"Health Sciences, Department of Endocrinology and Metabolism, Federal University of Rio Grande do Norte, Caic\u00f3, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,5,1]]},"reference":[{"key":"bibr1-13-204","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.06.023"},{"key":"bibr2-13-204","first-page":"33","volume":"62","author":"Beck M.","year":"2010","journal-title":"Life."},{"key":"bibr3-13-204","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3282f161f2"},{"key":"bibr4-13-204","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13640.x"},{"key":"bibr5-13-204","first-page":"461","volume":"75","author":"Defraia E.","year":"2005","journal-title":"Angle Orthod."},{"key":"bibr6-13-204","first-page":"98","volume":"17","author":"Downs A.T.","year":"1995","journal-title":"Am Acad Pediatr 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