{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:35:10Z","timestamp":1789940110053,"version":"4.0.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Can a synthetic bone substitute be used to repair the alveolar cleft to bypass donor site morbidity as well as to shorten the operating time? In earlier experimental studies, micro-structured beta-tricalcium phosphate (\u03b2-TCP) provided similar bone healing when compared with grafting with iliac crest bone. This justifies the clinical evaluation of this bone substitute in the human alveolar cleft situation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective clinical study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Seven patients, all with unilateral alveolar cleft, were randomly included for alveolar cleft repair with \u03b2-TCP in 2010 and 2011.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>In all patients, the alveolar cleft was repaired by micro-structured \u03b2-TCP grafting. Our assessments were distilled from cone beam computed tomography scans taken preoperatively, 1 week postoperatively, and 6 months postoperatively. A volumetric outcome could be realized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six months after the operative grafting of micro-structured \u03b2-TCP into the alveolar cleft, the bone volume thus acquired was satisfactory. We found an average bone volume percentage of 73% \u00b1 6% compared with the original cleft volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Previous experimental and clinical studies and the initial findings of this pilot study now elucidate a path toward the clinical use of micro-structured \u03b2-TCP bone substitute for repair of the alveolar cleft.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/13-260","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T15:43:04Z","timestamp":1402501384000},"page":"336-340","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Micro-structured Beta-Tricalcium Phosphate for Repair of the Alveolar Cleft in Cleft Lip and Palate Patients: A Pilot Study"],"prefix":"10.1177","volume":"52","author":[{"given":"Ad","family":"De Ruiter","sequence":"first","affiliation":[{"name":"University Medical Centre, Department of Oral and Maxillofacial Surgery, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nard","family":"Janssen","sequence":"additional","affiliation":[{"name":"University Medical Centre, Department of Oral and Maxillofacial Surgery, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Van Es","sequence":"additional","affiliation":[{"name":"University Medical Centre, Department of Oral and Maxillofacial Surgery, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Frank","sequence":"additional","affiliation":[{"name":"University Medical Centre, Department of Oral and Maxillofacial Surgery, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Meijer","sequence":"additional","affiliation":[{"name":"Radboud University Medical Centre, Department of Periodontology and Biomaterials, Nijmegen, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Koole","sequence":"additional","affiliation":[{"name":"University Medical Centre, Department of Oral and Maxillofacial Surgery, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toine","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"University Medical Centre, Department of Oral and Maxillofacial Surgery, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,1]]},"reference":[{"key":"bibr1-13-260","first-page":"389","volume":"76","author":"Andra A.","year":"1988","journal-title":"Zahn Mund Kieferheilkd 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