{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:21:20Z","timestamp":1777522880725,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the frequency of delayed puberty in adolescents with cleft lip and\/or cleft palate (CL\/P).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This was a cross-sectional study of 203 patients with CL\/P and no associated syndromes treated at the Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru, Brazil. We evaluated boys aged 14-19 years and girls aged 13-18 years. The patients were classified according to Tanner stages of sexual development. The age of menarche was recorded. Patients were assigned to three groups according to cleft type: isolated cleft lip (CL), cleft lip and palate (CLP), and isolated cleft palate (CP). The results were expressed as frequencies and averages and compared with pubertal changes described for typically developing adolescents as reported in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subjects were 115 boys and 88 girls. All boys in the CL group and the CP group had already started puberty, and two boys in the CLP group (2.3%) had delayed puberty. All girls had started puberty. The average age at menarche was 12.3 years in the CL group, 12.1 years in the CLP group, and 12.5 years in the CP group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The frequency of delayed puberty and the average age at menarche in adolescents with CL\/P and no associated genetic syndromes or anomalies were within the expected range for typically developing adolescents (i.e., those without CL\/P) in the same age group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1597\/14-175","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T14:40:06Z","timestamp":1445956806000},"page":"464-468","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Delayed Puberty in Adolescents with Cleft Lip\/Palate"],"prefix":"10.1177","volume":"53","author":[{"given":"Maria Cristina","family":"Cr\u00eas","sequence":"first","affiliation":[{"name":"Pediatrician Endocrinologist, Hospital Estadual Bauru, FAMESP\/Organiza\u00e7\u00e3o Social de Sa\u00fade, Bauru, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilza Lazarini","family":"Marques","sequence":"additional","affiliation":[{"name":"Pediatrician and Director of Medical Service, Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heloisa","family":"Bettiol","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, Department of Pediatrics, Faculdade de Medicina de Ribeir\u00e3o Preto, Ribeir\u00e3o Preto, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"bibr1-14-175","doi-asserted-by":"publisher","DOI":"10.1597\/08-094"},{"key":"bibr2-14-175","first-page":"73","volume-title":"Fissuras Labiopalatinas: Uma Abordagem Inter disciplinar.","author":"Bertier C.E.","year":"2007"},{"key":"bibr3-14-175","doi-asserted-by":"publisher","DOI":"10.3109\/02844318709083572"},{"key":"bibr4-14-175","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31447"},{"key":"bibr5-14-175","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70097-0"},{"issue":"4","key":"bibr6-14-175","first-page":"30","volume":"9","author":"Garib D.G.","year":"2010","journal-title":"Ver Cl\u00edn Ortodon Dent Press."},{"key":"bibr7-14-175","first-page":"311","volume-title":"Fissuras Labiopalatinas: Uma Abordagem Interdisciplinar.","author":"Graciano M.I.G.","year":"2007"},{"key":"bibr8-14-175","doi-asserted-by":"publisher","DOI":"10.3109\/00016359509005963"},{"key":"bibr9-14-175","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.06.022"},{"key":"bibr10-14-175","first-page":"576","volume":"24","author":"Laron Z.","year":"1969","journal-title":"Helv Paediatr Acta."},{"key":"bibr11-14-175","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1795-9_106"},{"key":"bibr12-14-175","doi-asserted-by":"publisher","DOI":"10.1597\/08-105.1"},{"key":"bibr13-14-175","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"bibr14-14-175","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"issue":"6","key":"bibr15-14-175","first-page":"461","volume":"81","author":"Montagnoli L.C.","year":"2005","journal-title":"J Pediatr."},{"key":"bibr16-14-175","first-page":"162","volume-title":"Embriologia Cl\u00ednica.","author":"Moore L.K.","year":"2008"},{"key":"bibr17-14-175","first-page":"406","volume-title":"Embriologia Cl\u00ednica.","author":"Moore L.K.","year":"2008"},{"key":"bibr18-14-175","first-page":"830","volume":"4","author":"Muhamad A.H.","year":"2012","journal-title":"Indian J Dent Adv."},{"key":"bibr19-14-175","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.10.018"},{"key":"bibr20-14-175","first-page":"246","volume-title":"Pr\u00e1tica pedi\u00e1trica: endocrinologia.","author":"Nakamoto 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Health Organization. Global strategies to reduce the health-care burden of craniofacial anomalies. Geneva. 2002. Available at http:\/\/www.nidcr.nih.gov\/NR\/rdonlyres\/8BF00CA3-AA3D-468E-97A7-68674D58E673\/0\/CraniofacialA. 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