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Two affected brothers from a second family, also born to first-cousin parents, shared a region of homozygosity that included the second gene known to cause the 3MC syndrome, MASP1. We discuss the diagnostic approach of craniofacial disorders born to consanguineous parents and highlight a literature search and reference a helpful dysmorphology solution powered by FDNA (Facial Dysmorphology Novel Analysis) technology.<\/jats:p>","DOI":"10.1597\/15-151","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T19:19:40Z","timestamp":1467227980000},"page":"739-748","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Familial Recurrence of 3MC Syndrome in Consanguineous Families: A Clinical and Molecular Diagnostic Approach with review of the Literature"],"prefix":"10.1177","volume":"54","author":[{"given":"Olivia K.","family":"Gardner","sequence":"first","affiliation":[{"name":"Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, 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