{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:50:19Z","timestamp":1773802219756,"version":"3.50.1"},"reference-count":0,"publisher":"Association for the Advancement of Artificial Intelligence (AAAI)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AAAI"],"abstract":"<jats:p>Standardized microplates are used to conduct large-scale biomedical research. The design of microplate layouts plays an essential role in handling so-called plate effects, i.e., systematic variations across the geometry of a microplate. An effective layout allows us to detect and negate plate effects. The randomized placement of controls and compounds produces layouts of limited effectiveness, so specific approaches are needed. A previously developed system, PLAID, proposed a constraint satisfaction model to construct effective plate layouts. However, PLAID does not scale well with microplate dimensions. To improve on PLAID, we propose Constraint Optimization of MicroPlate Designs (COMPD), which allows for greater flexibility and higher quality of the layouts.<\/jats:p>","DOI":"10.1609\/aaai.v40i17.38438","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:30:37Z","timestamp":1773793837000},"page":"14243-14250","source":"Crossref","is-referenced-by-count":0,"title":["Constraint Optimization of MicroPlate Designs"],"prefix":"10.1609","volume":"40","author":[{"given":"Ramiz","family":"Gindullin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Andre\u00edna Francisco","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9382","published-online":{"date-parts":[[2026,3,14]]},"container-title":["Proceedings of the AAAI Conference on Artificial Intelligence"],"original-title":[],"link":[{"URL":"https:\/\/ojs.aaai.org\/index.php\/AAAI\/article\/download\/38438\/42400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojs.aaai.org\/index.php\/AAAI\/article\/download\/38438\/42400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:30:38Z","timestamp":1773793838000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.aaai.org\/index.php\/AAAI\/article\/view\/38438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,14]]},"references-count":0,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,3,17]]}},"URL":"https:\/\/doi.org\/10.1609\/aaai.v40i17.38438","relation":{},"ISSN":["2374-3468","2159-5399"],"issn-type":[{"value":"2374-3468","type":"electronic"},{"value":"2159-5399","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,14]]}}}