{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:10:56Z","timestamp":1792343456488,"version":"4.4.0"},"reference-count":10,"publisher":"Begell House","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Crit Rev Immunol"],"published-print":{"date-parts":[[2023]]},"abstract":"<p>Angioedema is a condition characterized by swelling of the skin or mucosa resulting from loss of vascular integrity that leads to swelling of mucosal tissues and can lead to life-threatening respiratory compromise. Drug-induced angioedema is not a frequent side effect seen with angiotensin receptor blockers (ARBs), particularly when there are no other contributing risk factors like a prior episode. Few studies reported subsequent angioedema episodes after ARB use in patients who had a prior episode with angiotensin converting enzyme inhibitors; however, there are very few cases that documented non-fatal angioedema after ARB as the only therapy. We report a rare case of life-threatening anaphylaxis after losartan use. We hope that our case will bring awareness to this rare but fatal side effect in order to quickly recognize it and encourage further research.\n<\/p>","DOI":"10.1615\/critrevimmunol.2023050290","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T14:42:03Z","timestamp":1694011323000},"page":"11-13","source":"Crossref","is-referenced-by-count":2,"title":["Losartan-Induced Angioedema with Acute Hypoxemic Respiratory Failure (Anaphylaxis): A Case Report"],"prefix":"10.1615","volume":"43","author":[{"given":"Yusuf","family":"Kagzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Bradley","family":"Money","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asa Zoe","family":"Oxner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alifiya","family":"Kagzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"613","reference":[{"key":"2","doi-asserted-by":"crossref","unstructured":"Niazi BA, Kaur M, Mosseri M, Lo A. A rare case of dose-dependent losartan-induced angioedema. Cureus. 2022;14(4):e24110.","DOI":"10.7759\/cureus.24110"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Chiu AG, Krowiak EJ, Deeb ZE. Angioedema associated with angiotensin II receptor antagonists: Challenging our knowledge of angioedema and its etiology. Laryngoscope. 2001;111(10):1729-31.","DOI":"10.1097\/00005537-200110000-00011"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Patel G, Pongracic JA. Hereditary and acquired angioedema. Allergy Asthma Proc. 2019;40(6):441-5.","DOI":"10.2500\/aap.2019.40.4267"},{"key":"5","unstructured":"Hill RD, Vaidya PN. Angiotensin II receptor blockers (ARB). Treasure Island, FL: StatPearls Publishing; 2023."},{"key":"6","doi-asserted-by":"crossref","unstructured":"Van Rijnsoever EW, Kwee-Zuiderwijk WJM, Feenstra J. Angioneuroticedema attributed to the use of losartan. Arch Intern Med. 1998;158:2063-5","DOI":"10.1001\/archinte.158.18.2063"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Brown, T, Gonzalez, J, Monteleone, C. Angiotensin-converting enzyme inhibitor-induced angioedema: A review of the literature. J Clin Hypertens. 2017;19:1377-82.","DOI":"10.1111\/jch.13097"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Makani H, Messerli FH, Romero J, Wever-Pinzon O, Korniyenko A, Berrios RS, Bangalore S. Meta-analysis of randomized trials of angioedema as an adverse event of renin-angiotensin system inhibitors. Am J Cardiol. 2012;110(3):383-91.","DOI":"10.1016\/j.amjcard.2012.03.034"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Fuchs SA, Meyboom RH, van Puijenbroek EP, Guchelaar HJ. Use of angiotensin receptor antagonists in patients with ACE inhibitor induced angioedema. Pharm World Sci. 2004;26(4):191-2.","DOI":"10.1023\/B:PHAR.0000035902.67235.5c"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Dasarathy Y, Lanzillo JJ, Fanburg BL. Stimulation of bovine pulmonaryartery endothelial cell ACE by dexamethasone: Involvement of steroid receptors. Am J Physiol. 1992;263:L645-9.","DOI":"10.1152\/ajplung.1992.263.6.L645"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Bas M, Greve J, Stelter K, Bier H, Stark T, Hoffmann TK, Kojda G. Therapeutic efficacy of icatibant in angioedema induced by angiotensin-converting enzyme inhibitors: A case series. Ann Emerg Med. 2010;56(3):278-82.","DOI":"10.1016\/j.annemergmed.2010.03.032"}],"container-title":["Critical Reviews in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dl.begellhouse.com\/download\/article\/6b5746551556f1d0\/CRI-50290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:23:08Z","timestamp":1696922588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dl.begellhouse.com\/journals\/2ff21abf44b19838,440a6c482b840700,6b5746551556f1d0.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1615\/critrevimmunol.2023050290","relation":{},"ISSN":["1040-8401"],"issn-type":[{"value":"1040-8401","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}