{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T05:15:45Z","timestamp":1740546945280,"version":"3.38.0"},"reference-count":119,"publisher":"Begell House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Crit Rev Immunol"],"published-print":{"date-parts":[[2025]]},"abstract":"<p>Neonatal candidiasis poses significant clinical challenges due to its potential for severe morbidity and mortality in vulnerable infants. Due to their underdeveloped immune system, neonates are at a higher risk for infections caused by &lt;i&gt;Candida &lt;\/i&gt;species. They can vary from mild to severe, including penetrating deep tissues, bloodstream spread, and dissemination to organs. The immune system of newborns is marked by a limited innate immune response, with lower levels of pro-inflammatory cytokines. Adaptive immunity, important for lasting protection, also experiences delayed maturation with weakened Th1 and Th17 responses. These shortcomings result in a higher vulnerability to &lt;i&gt;Candida&lt;\/i&gt; infections during infancy. Murine models have been crucial in understanding the reasons behind this susceptibility. These models assist in examining how different immune elements, like neutrophils, macrophages, and T cells, and their interactions are involved in &lt;i&gt;Candida&lt;\/i&gt; infections. Moreover, they offer an understanding of how early-life exposure to &lt;i&gt;Candida&lt;\/i&gt; affects immune responses and may aid in developing possible therapeutic plans. In this article we review current results from research to provide a thorough summary and critical insights into neonatal immune response to &lt;i&gt;Candida&lt;\/i&gt;, highlighting the importance of using murine models in this field of study. Understanding these immune dynamics is essential for creating specific treatments and preventive strategies to prevent newborns from &lt;i&gt;Candida &lt;\/i&gt;infections, ultimately improving neonatal health outcomes.\n<\/p>","DOI":"10.1615\/critrevimmunol.2024055053","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T21:49:13Z","timestamp":1734126553000},"page":"63-76","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal Immunity to Candida: Current Understanding and Contributions of Murine Models"],"prefix":"10.1615","volume":"45","author":[{"given":"Angel","family":"Palacios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fides Myles C.","family":"Caliwag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Becerril-Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"613","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Yapar N. 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