{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:32:35Z","timestamp":1758040355050,"version":"3.44.0"},"reference-count":90,"publisher":"Begell House","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Crit Rev Immunol"],"published-print":{"date-parts":[[2025]]},"abstract":"<p>Stemming from human immune organs, tonsil-derived mesenchymal stem cells (TMSCs) hold unique strengths in differentiation potential and immune regulatory functions. These characteristics make them valuable for therapeutic applications, particularly in regenerative medicine and autoimmune disease treatment, as they can modulate immune responses and promote tissue repair. Their ability to interact with various cell types and secrete a range of bioactive molecules further enhances their role in orchestrating healing processes, making them a promising avenue for innovative therapies aimed at restoring balance in the immune system and facilitating recovery from injury or disease. TMSCs are crucial elements of the tonsillar microenvironment, playing a key role in preserving the balance of the immune system. They regulate immune responses by producing cytokines and growth factors, influencing neighboring immune cells, and facilitating communication within tonsillar tissue to maintain a controlled response to pathogens and prevent excessive inflammation. As understanding of TMSCs continues to evolve, their integration into clinical practices could revolutionize approaches to treating a wide array of conditions, highlighting the importance of continued investigation in this promising field.<\/p>","DOI":"10.1615\/critrevimmunol.2025059511","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T10:43:56Z","timestamp":1750761836000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Immunomodulatory Roles of Tonsil-Derived Mesenchymal Stem Cells"],"prefix":"10.1615","volume":"45","author":[{"given":"Yue","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Gui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinliang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"613","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Wagar LE, Salahudeen A, Constantz CM, Wendel BS, Lyons MM, Mallajosyula V, Jatt LP, Adamska JZ, Blum LK, Gupta N, Jackson KJL, Yang F, Roltgen K, Roskin KM, Blaine KM, Meister KD, Ahmad IN, Cortese M, Dora EG, Tucker SN, Sperling AI, Jain A, Davies DH, Felgner PL, Hammer GB, Kim PS, Robinson WH, Boyd SD, Kuo CJ, and Davis MM. 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