{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:43:36Z","timestamp":1772639016647,"version":"3.50.1"},"reference-count":38,"publisher":"Begell House","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Crit Rev Immunol"],"published-print":{"date-parts":[[2025]]},"abstract":"<p>Galectin-10(Gal-10)\/CLC(Charcot-Leyden crystal) has been discovered to be related to ECRSwNP characterized by high eosinophilic infiltration. We aimed to investigate the effects of Gal-10 on ECRSwNP. A total of 36 tissue samples were collected, including 11 ECRSwNP samples, 15 non-ECRSwNP samples, and 10 Control samples. Human eosinophils were divided into 3 groups: Control, siRNA-NC, and Gal-10 interference groups. Immunohistochemistry (IHC), Western blotting and quantitative real-time PCR (qRT-PCR) detected the expression of Gal-10 in the tissues samples and expression of p-p38 and p-p65 in human eosinophils. Enzyme-Linked Immunosorbent Assay (ELISA) was adopted to measure the expression levels of IL-4, IL-5, IL-8, MBP, ECP, and TNF-&amp;alpha; in the human eosinophils. We found the expression of Gal-10 was significantly higher in ECRSwNP group (&lt;i&gt;P&lt;\/i&gt; &amp;#60; 0.05). The expression levels of IL-4, IL-5, IL-8, MBP and TNF-&amp;alpha; in the Gal-10 interference group were lower (&lt;i&gt;P&lt;\/i&gt; &amp;#60;  0.05), but ECP had no statistical difference in human eosinophils. There showed the expression levels of p-p38 and p-p65 proteins in the Gal-10 interference group were lower (&lt;i&gt;P&lt;\/i&gt; &amp;#60;  0.05). The deletion of Gal-10 in eosinophils down-regulates the expression of cytokines and granule cationic proteins in ECRSwNP which may be caused by the p38MAPK\/ NF-&amp;kappa;B pathway.\n<\/p>","DOI":"10.1615\/critrevimmunol.2025060503","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T14:32:53Z","timestamp":1755613973000},"page":"67-78","source":"Crossref","is-referenced-by-count":1,"title":["Galectin-10 Silencing Reduces Eosinophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps by Inhibiting the p38\/MAPK\/NF-&amp;kappa;B Pathway"],"prefix":"10.1615","volume":"45","author":[{"given":"Chunhua","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HongBing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"613","reference":[{"key":"2","doi-asserted-by":"crossref","unstructured":"Liu Z, Chen J, Cheng L, Li H, Zhang L. 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