{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:01:45Z","timestamp":1785013305603,"version":"3.55.0"},"reference-count":3,"publisher":"Begell House","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Crit Rev Oncog"],"published-print":{"date-parts":[[2026]]},"abstract":"<p>This article provides a personal and professional retrospective of the life and career of Professor Zelig Eshhar, a visionary immunologist whose work laid the foundation for Chimeric Antigen Receptor (CAR) T-cell therapy. Authored by Tova Waks, his long-time collaborator of 55 years.<\/p>","DOI":"10.1615\/critrevoncog.2026063205","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T15:36:27Z","timestamp":1768232187000},"page":"xv-xix","source":"Crossref","is-referenced-by-count":0,"title":["Zelig Eshhar: The Pioneer Who Re-Engineered the T-Cells and Brought CAR-T into the World"],"prefix":"10.1615","volume":"31","author":[{"given":"Tova","family":"Waks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"613","reference":[{"key":"2","doi-asserted-by":"crossref","unstructured":"Eshhar Z. Specificity of heterologous antisera to components solubilized from rat thymocyte membranes. Eur J Immunol. 1973;3:668.","DOI":"10.1002\/eji.1830031103"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Kaufmann Y, Berke G, Eshhar Z. Cytotoxic T lymphocyte hybridomas that mediate specific tumor-cell lysis in vitro. Proc Natl Acad Sci USA. 1981;78:2502.","DOI":"10.1073\/pnas.78.4.2502"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Eshhar Z, Waks T, Gross G, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci USA. 1993;90:720-724.","DOI":"10.1073\/pnas.90.2.720"}],"container-title":["Critical Reviews\u2122 in Oncogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dl.begellhouse.com\/download\/article\/1ebb23361866d2e0\/CRO-63205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T20:33:53Z","timestamp":1785011633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dl.begellhouse.com\/journals\/439f422d0783386a,5a518e4904bba712,1ebb23361866d2e0.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":3,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1615\/critrevoncog.2026063205","relation":{},"ISSN":["0893-9675"],"issn-type":[{"value":"0893-9675","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}