{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:01:20Z","timestamp":1784869280095,"version":"3.55.0"},"reference-count":35,"publisher":"Begell House","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Environ Pathol Toxicol Oncol"],"published-print":{"date-parts":[[2025]]},"abstract":"<p>&lt;b&gt;Background:&lt;\/b&gt; Circular RNAs (circRNAs) play a pivotal part in the advancement of multiple tumors. Nonetheless, the influence of &lt;i&gt;Helicobacter pylori (H. pylori)&lt;\/i&gt; infection on the expression of circRNA in gastric cancer remains less studied.\n\n&lt;b&gt;Aim: &lt;\/b&gt;The objective of this research is to clarify the function and underlying mechanism of circ_0075829 in the context of gastric cancer and its relation to &lt;i&gt;H. pylori &lt;\/i&gt;infection.\n\n&lt;b&gt;Methods:&lt;\/b&gt; The circ_0075829 expression in tissue specimens and cells was evaluated utilizing quantitative real-time PCR (RT-qPCR). &lt;i&gt;H. pylori &lt;\/i&gt;infection and transfection were treated in gastric cancer cells to measure circ_0075829 expression changes and their effects on cellular behaviors. Kaplan-Meier curve was conducted to assess the clinical prognostic performance of circ_0085729 in patients with gastric cancer. Bioinformatics and dua-luciferase reporter assay were performed to validate the downstream miRNA and mRNA. CCK-8 proliferation assay and transwell experiments were carried out to investigate the influence of circ_0075829-miR-149-5p-AGO1 on cellular activities.\n\n&lt;b&gt;Results:&lt;\/b&gt; Circ_0075829 expression was increased in gastric cancer and correlated with several clinical characteristics and shorter overall survival. Besides, &lt;i&gt;H. pylori &lt;\/i&gt;infection increased circ_0075829 expression in cancer cells. miR-149-5p was a direct target miRNA of circ_0075829 and was downregulated in gastric cancer. Downregulation of circ_0075829 could repress the proliferative abilities, migratory capacities, and invasion potential of cancer cells by mediating miR-149-5p to regulate AGO1 expression.\n\n&lt;b&gt;Conclusion:&lt;\/b&gt; Circ_0075829 seems to play an oncogenic role in &lt;i&gt;H. pylori&lt;\/i&gt;-associated gastric malignancies and may serve as a promising indicator for predicting outcomes in gastric cancer, which underpins a more theoretical basis for the progression of new therapeutic approaches to treating gastric cancer.<\/p>","DOI":"10.1615\/jenvironpatholtoxicoloncol.2025054934","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T10:43:47Z","timestamp":1736246627000},"page":"1-13","source":"Crossref","is-referenced-by-count":1,"title":["Increased hsa_circ_0075829 Facilitates the Progression of Gastric Cancer and Its Relationship with Helicobacter Pylori Infection"],"prefix":"10.1615","volume":"44","author":[{"given":"Zhentao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"613","reference":[{"key":"2","doi-asserted-by":"crossref","unstructured":"L\u00f3pez MJ, Carbajal J, Alfaro AL, Saravia LG, Zanabria D, Araujo JM, Quispe L, Zevallos A, Buleje JL, Cho CE, Sarmiento M, Pinto JA, Fajardo W. Characteristics of gastric cancer around the world. Crit Rev Oncol Hematol. 2023;181:103841.","DOI":"10.1016\/j.critrevonc.2022.103841"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Ling LX, Ouyang Y, Hu Y. Research trends on nanomaterials in gastric cancer: A bibliometric analysis from 2004 to 2023. J Nanobiotechnol. 2023;21(1):248.","DOI":"10.1186\/s12951-023-02033-8"},{"key":"4","doi-asserted-by":"crossref","unstructured":"He F, Wang S, Zheng R, Gu J, Zeng H, Sun K, Chen R, Li L, Han B, Li X, Wei W, He J. Trends of gastric cancer burdens attributable to risk factors in China from 2000 to 2050. 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