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Various natural products obtained from medicinal plants; that is, phytochemicals have been reported to possess aluminum toxicity ameliorative potential. Still now, there is no comprehensive review in this regard. A compilation of research has been published over the past 21 years on the protective properties of plant-derived phytochemicals against the toxicity of aluminum. Reportedly, 45 phytochemicals of diverse chemical classes mitigate the toxicity of experimental aluminum in animals\/cells\/tissues, leading to marked reduction of aluminum-induced pathophysiological complications, by multiple mechanisms; the prime typical modes, among others, are modulation of oxidative stress-inflammatory pathways and anti-cholinesterase activity. These recent advances may help to develop a potential nutraceutical or phytomedicinal candidate against aluminum toxicity and neurodegenerative diseases for humans.<\/p>","DOI":"10.1615\/jenvironpatholtoxicoloncol.2025056997","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:29:56Z","timestamp":1770049796000},"page":"79-97","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemicals for Ameliorating Aluminum Toxicity: Dissecting the Mechanisms for Therapeutic Potential"],"prefix":"10.1615","volume":"45","author":[{"given":"Sanjib","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"613","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Alasfar RH and Isaifan RJ. Aluminum environmental pollution, the silent killer. 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