{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:48:03Z","timestamp":1767008883054,"version":"3.40.5"},"reference-count":25,"publisher":"Begell House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Long Term Eff Med Implants"],"published-print":{"date-parts":[[2025]]},"abstract":"<p>Carrageenans are the sulfated polysaccharides, extracted from the extracellular matrix of red seaweeds. Peri-implantitis is a pathological condition occurring in tissues around dental implants. Management of peri-implantitis should be concerned with control of infection, detoxification of the implant site and regeneration of alveolar bone. The goal of our study was to develop a membrane infused with carrageenan and fucoidan silica nanoparticles for guided bone regeneration around implant sites. Carrageenan (2&amp;#37;) was boiled for 2 min and 5&amp;#37; of fucoidan were added and boiled at 60&amp;deg;C and further 4000 &amp;mu;L of PEG was added, then film casting of membrane was done. 10 ml of silica nanoparticles were mixed in 0.1 g of SiO&lt;sub&gt;2&lt;\/sub&gt; nanoparticles and were added to prepared carrageenan and fucoidan solution. Then film casting was done and air dried for 24 h. Antimicrobial assay, antioxidant activity, swelling and degradation analysis, FTIR test, tensile strength testing and SEM analysis were performed. The antimicrobial effect of carrageenan membrane showed better inhibitory effect against &lt;i&gt;Streptococcus mutans&lt;\/i&gt;. Antioxidant activity of the membrane infused with carrageenan and fucoidan silica nanoparticles shows 52.93 &amp;#177; 0.35 SC effect percentage. The maximum force of tensile stress at break for carrageenan fucoidan incorporated with silica nanoparticles was about 5.76 MPa and for control sample membrane was 4.34 Mpa. Carrageenan and fucoidan based silica nanoparticles developed membrane showed good tensile strength and proven to have better antimicrobial, antioxidant activity with water absorption capacity which can be effectively used for guided bone regeneration around implant sites.\n<\/p>","DOI":"10.1615\/jlongtermeffmedimplants.2024049789","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T19:31:07Z","timestamp":1731353467000},"page":"25-32","source":"Crossref","is-referenced-by-count":5,"title":["Preparation of a Carrageenan and Fucoidan Silica Nanoparticle-Based Membrane for Guided Bone Regeneration in Dental Implant Sites"],"prefix":"10.1615","volume":"35","author":[{"given":"L.","family":"Akshayaa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balaji S.","family":"Ganesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"613","reference":[{"issue":"11","key":"2","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.2174\/1381612825666190425190754","article-title":"Carrageenan: A wonder polymer from marine algae for potential drug delivery applications","volume":"25","author":"Qureshi D.","year":"2019","journal-title":"Curr Pharm Des"},{"issue":"1","key":"3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74845-9","article-title":"Therapeutic effects of antibiotics loaded cellulose nanofiber and k-carrageenan oligosaccharide composite hydrogels for periodontitis treatment","volume":"10","author":"Johnson A.","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"4","doi-asserted-by":"crossref","DOI":"10.1186\/s12903-022-02409-6","article-title":"Biocompatibility and antioxidant activity of a novel carrageenan based injectable hydrogel scaffold incorporated with Cissus quadrangularis: An in vitro study","volume":"22","author":"Sairaman S.","year":"2022","journal-title":"BMC Oral Health"},{"key":"5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.carbpol.2018.06.086","article-title":"Carrageenan based hydrogels for drug delivery, tissue engineering and wound healing","volume":"198","author":"Yegappan R.","year":"2018","journal-title":"Carbohydr Polym"},{"issue":"1","key":"6","doi-asserted-by":"crossref","DOI":"10.1007\/s11033-023-09146-1","article-title":"Marine-derived k-carrageenan-coated zinc oxide nanoparticles for targeted drug delivery and apoptosis induction in oral cancer","volume":"51","author":"Marunganathan V.","year":"2024","journal-title":"Mol Biol Rep"},{"issue":"1","key":"7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/2320206820980248","article-title":"Internet of things-a novel innovation in dentistry","volume":"12","author":"Balaji Ganesh S.","year":"2021","journal-title":"J Adv Oral Res"},{"key":"8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.apradiso.2013.04.035","article-title":"Antioxidant activity potential of gamma irradiated carrageenan","volume":"79","author":"Abad L.V.","year":"2013","journal-title":"Appl Radiat Isot"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1615\/JLongTermEffMedImplants.2022043121","article-title":"Microbiological profile in periodontitis and peri-implantitis: A systematic review","volume":"32","author":"Rajasekar A.","year":"2022","journal-title":"J Long Term Eff Med Implants"},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-0501.1997.tb00002.x","article-title":"Guided bone regeneration in dental implant treatment using a bioabsorbable membrane","volume":"8","author":"Mayfield L.","year":"1997","journal-title":"Clin Oral Implants Res"},{"issue":"19","key":"11","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1016\/j.biomaterials.2004.09.014","article-title":"Guided bone regeneration membrane made of polycaprolactone\/calcium carbonate composite nano-fibers","volume":"26","author":"Fujihara K.","year":"2005","journal-title":"Biomaterials"},{"issue":"5","key":"12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/eos.12364","article-title":"Guided bone regeneration: Materials and biological mechanisms revisited","volume":"125","author":"Elgali I.","year":"2017","journal-title":"Eur J Oral Sci"},{"issue":"2","key":"13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jcis.2008.01.035","article-title":"Rheological behavior of thermoreversible kappa-carrageenan\/nanosilica gels","volume":"320","author":"Daniel-Da-Silva A.L.","year":"2008","journal-title":"J Colloid Interf Sci"},{"key":"14","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.837858","article-title":"Fabrication of guided tissue regeneration membrane using lignin-mediated ZnO nanoparticles in biopolymer matrix for antimicrobial activity","volume":"10","author":"Bilal B.","year":"2022","journal-title":"Front Chem"},{"issue":"3","key":"15","article-title":"Development of a Cissus quadrangularis-doped extracellular matrix and a hyaluronic acid-incorporated scaffold for periodontal regeneration: An in vitro study","volume":"16","author":"Ganesh S.B.","year":"2024","journal-title":"Cureus"},{"issue":"2","key":"16","article-title":"Hyaluronic acid hydrogel combined with ocimum sanctum and tendon-derived extracellular matrix enhances tenogenesis in periodontal ligament stem cells","volume":"16","author":"Aardra B.S.","year":"2024","journal-title":"Cureus"},{"issue":"11","key":"17","doi-asserted-by":"crossref","DOI":"10.3390\/md18110571","article-title":"Fucoidan characterization: Determination of purity and physicochemical and chemical properties","volume":"18","author":"Zayed A.","year":"2020","journal-title":"Mar Drugs"},{"issue":"6","key":"18","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.sdentj.2023.05.021","article-title":"Fabrication of hydroxyapatite reinforced polymeric hydrogel membrane for regeneration","volume":"35","author":"Kishen A.","year":"2023","journal-title":"Saudi Dent J"},{"issue":"39","key":"19","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.1039\/C4TB00737A","article-title":"Fabrication and evaluation of electrospun PCL-gelatin micro-\/nanofiber membranes for anti-infective GTR implants","volume":"2","author":"Xue J.","year":"2014","journal-title":"J Mater Chem B"},{"issue":"12","key":"20","doi-asserted-by":"crossref","first-page":"5985","DOI":"10.1021\/acsabm.9b00912","article-title":"Injectable adhesive hydrogel through a microcapsule cross-link for periodontitis treatment","volume":"2","author":"Dong Z.","year":"2019","journal-title":"ACS Appl Bio Mater"},{"issue":"3","key":"21","article-title":"Transglutaminase cross-linked gelatin-alginate-antibacterial hydrogel as the drug delivery-coatings for implant-related infections","volume":"13","author":"Sun C.K.","year":"2021","journal-title":"Polymers"},{"issue":"2","key":"22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4103\/jisp.jisp_678_21","article-title":"The implication of mitochondrial DNA mutation and dysfunction in periodontal diseases","volume":"27","author":"Kannan B.","year":"2023","journal-title":"J Indian Soc Periodontol"},{"issue":"10","key":"23","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1039\/D1BM00164G","article-title":"A flexible fibrous membrane based on copper (ii) metal-organic framework\/poly (lactic acid) composites with superior antibacterial performance","volume":"9","author":"Liu Z.","year":"2021","journal-title":"Biomater Sci"},{"issue":"21","key":"24","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.2217\/nnm-2023-0180","article-title":"Nanotechnology-based mucoadhesive and mucus-penetrating drug-delivery systems for transbuccal drug delivery","volume":"18","author":"Desai D.D.","year":"2023","journal-title":"Nanomedicine"},{"issue":"7","key":"25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.dental.2012.04.022","article-title":"Recent advances in the development of GTR\/GBR membranes for periodontal regeneration-a materials perspective","volume":"28","author":"Bottino M.C.","year":"2012","journal-title":"Dent Mater"},{"issue":"3","key":"26","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s10266-016-0268-z","article-title":"Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating","volume":"105","author":"Shahi R.G.","year":"2017","journal-title":"Odontology"}],"container-title":["Journal of Long-Term Effects of Medical Implants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dl.begellhouse.com\/download\/article\/7514e82e62472a98\/JLT-49789.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T16:12:22Z","timestamp":1746720742000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dl.begellhouse.com\/journals\/1bef42082d7a0fdf,410626e27f6fdfa9,7514e82e62472a98.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1615\/jlongtermeffmedimplants.2024049789","relation":{},"ISSN":["1050-6934"],"issn-type":[{"type":"print","value":"1050-6934"}],"subject":[],"published":{"date-parts":[[2025]]}}}