{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:35:31Z","timestamp":1768318531596,"version":"3.49.0"},"reference-count":19,"publisher":"Tohoku University Medical Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2022]]},"DOI":"10.1620\/tjem.2022.j067","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T22:11:02Z","timestamp":1661379062000},"page":"103-110","source":"Crossref","is-referenced-by-count":17,"title":["COVID-19-Related Symptoms during the SARS-CoV-2 Omicron (B.1.1.529) Variant Surge in Japan"],"prefix":"10.1620","volume":"258","author":[{"given":"Tetsuya","family":"Akaishi","sequence":"first","affiliation":[{"name":"Department of Education and Support for Regional Medicine, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Kushimoto","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Katori","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tohoku University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Egusa","sequence":"additional","affiliation":[{"name":"Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Division of Craniofacial Anomalies, Tohoku University Graduate School of Dentistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoo","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Kure","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tohoku University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Education and Support for Regional Medicine, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiaki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Education and Support for Regional Medicine, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Education and Support for Regional Medicine, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Ohsawa","sequence":"additional","affiliation":[{"name":"Department of Education and Support for Regional Medicine, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Ishizawa","sequence":"additional","affiliation":[{"name":"Department of Education and Support for Regional Medicine, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Education and Support for Regional Medicine, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Imai","sequence":"additional","affiliation":[{"name":"Clinical Skills Laboratory, Tohoku University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Inaba","sequence":"additional","affiliation":[{"name":"Course of Radiological Technology, Health Sciences, Tohoku University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Iwamatsu-Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Dental Infection Control, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Onodera","sequence":"additional","affiliation":[{"name":"Department of Education and Support for Regional Medicine, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Education and Support for Regional Medicine, Tohoku University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Abdullah, F., Myers, J., Basu, D., Tintinger, G., Ueckermann, V., Mathebula, M., Ramlall, R., Spoor, S., de Villiers, T., Van der Walt, Z., Cloete, J., Soma-Pillay, P., Rheeder, P., Paruk, F., Engelbrecht, A.,  et al. (2022)  Decreased severity of disease during the first global omicron variant covid-19 outbreak in a large hospital in tshwane, south africa.  <i>Int. J. Infect. Dis<\/i>., 116, 38-42.","DOI":"10.1016\/j.ijid.2021.12.357"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Akaishi, T. &amp; Ishii, T.(2022)  Variation in the prevalence of cough symptoms 4-5 days after infection with SARS-CoV-2 between seasons with different prevalent strains.  <i>J. Gen. Fam. Med<\/i>., 23, 248-254.","DOI":"10.1002\/jgf2.536"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Akaishi, T., Kushimoto, S., Katori, Y., Kure, S., Igarashi, K., Fujita, M., Takayama, S., Abe, M., Kikuchi, A., Tanaka, J., Abe, Y., Imai, H., Inaba, Y., Iwamatsu-Kobayashi, Y., Nishioka, T.,  et al.(2021)  Discriminatory value of self-reported olfactory dysfunction in the prediction of coronavirus disease 2019.  <i>Intern. Med<\/i>., 60, 2905-2910.","DOI":"10.2169\/internalmedicine.7238-21"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Backer, J.A., Eggink, D., Andeweg, S.P., Veldhuijzen, I.K., van Maarseveen, N., Vermaas, K., Vlaemynck, B., Schepers, R., van den Hof, S., Reusken, C.B. &amp; Wallinga, J.(2022)  Shorter serial intervals in SARS-CoV-2 cases with Omicron BA.1 variant compared with Delta variant, the Netherlands, 13 to 26 December 2021.  <i>Euro Surveill.<\/i>, 27, 2200042.","DOI":"10.2807\/1560-7917.ES.2022.27.6.2200042"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Davies, N.G., Jarvis, C.I., Edmunds, W.J., Jewell, N.P.,  Diaz-Ordaz, K. &amp; Keogh, R.H.; CMMID COVID-19 Working Group (2021)  Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7.  <i>Nature<\/i>, 593, 270-274.","DOI":"10.1038\/s41586-021-03426-1"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Ishii, T., Kushimoto, S., Katori, Y., Kure, S., Igarashi, K., Fujita, M., Takayama, S., Abe, M., Tanaka, J., Kikuchi, A., Abe, Y., Imai, H., Inaba, Y., Iwamatsu-Kobayashi, Y., Nishioka, T.,  et al.(2021)  Predictors of SARS-CoV-2 positivity based on RT-PCR swab tests at a drive-through outpatient clinic for COVID-19 screening in Japan.  <i>Tohoku J. Exp. Med<\/i>., 253, 101-108.","DOI":"10.1620\/tjem.253.101"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Karim, S.S.A. &amp; Karim, Q.A.(2021)  Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic.  <i>Lancet<\/i>, 398, 2126-2128.","DOI":"10.1016\/S0140-6736(21)02758-6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Menni, C., Valdes, A.M., Polidori, L., Antonelli, M., Penamakuri, S., Nogal, A., Louca, P., May, A., Figueiredo, J.C., Hu, C., Molteni, E., Canas, L., \u00d6sterdahl, M.F., Modat, M., Sudre, C.H.,  et al.(2022)  Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study.  <i>Lancet<\/i>, 399, 1618-1624.","DOI":"10.1016\/S0140-6736(22)00327-0"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Nealon, J. &amp; Cowling, B.J.(2022)  Omicron severity: milder but not mild.  <i>Lancet<\/i>, 399, 412-413.","DOI":"10.1016\/S0140-6736(22)00056-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Petersen, E., Ntoumi, F., Hui, D.S., Abubakar, A., Kramer, L.D., Obiero, C., Tambyah, P.A., Blumberg, L., Yapi, R., Al-Abri, S., Pinto, T.C.A., Yeboah-Manu, D., Haider, N., Asogun, D., Velavan, T.P.,  et al.(2022)  Emergence of new SARS-CoV-2 Variant of Concern Omicron (B.1.1.529)  - highlights Africa\u2019s research capabilities, but exposes major knowledge gaps, inequities of vaccine distribution, inadequacies in global COVID-19 response and control efforts.  <i>Int. J. Infect. Dis<\/i>., 114, 268-272.","DOI":"10.1016\/j.ijid.2021.11.040"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Piersiala, K., Kakabas, L., Bruckova, A., Starkhammar, M. &amp; Cardell, L.O.(2022)  Acute odynophagia: a new symptom of COVID-19 during the SARS-CoV-2 Omicron variant wave in Sweden.  <i>J. Intern. Med<\/i>., 292, 154-161.","DOI":"10.1111\/joim.13470"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Sato, T., Ueha, R., Goto, T., Yamauchi, A., Kondo, K. &amp; Yamasoba, T.(2021)  Expression of ACE2 and TMPRSS2 proteins in the upper and lower aerodigestive tracts of rats: implications on COVID 19 infections.  <i>Laryngoscope<\/i>, 131, E932-E939.","DOI":"10.1002\/lary.29132"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Shirato, K., Nao, N., Katano, H., Takayama, I., Saito, S., Kato, F., Katoh, H., Sakata, M., Nakatsu, Y., Mori, Y., Kageyama, T., Matsuyama, S. &amp; Takeda, M.(2020)  Development of genetic diagnostic methods for detection for novel coronavirus 2019 (nCoV-2019) in Japan.  <i>Jpn. J. Infect. Dis<\/i>., 73, 304-307.","DOI":"10.7883\/yoken.JJID.2020.061"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Song, J.S., Lee, J., Kim, M., Jeong, H.S., Kim, M.S., Kim, S.G., Yoo, H.N., Lee, J.J., Lee, H.Y., Lee, S.E., Kim, E.J., Rhee, J.E., Kim, I.H. &amp; Park, Y.J.(2022)  Serial intervals and household transmission of SARS-CoV-2 Omicron variant, South Korea, 2021.  <i>Emerg. Infect. Dis<\/i>., 28, 756-759.","DOI":"10.3201\/eid2803.212607"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Twohig, K.A., Nyberg, T., Zaidi, A., Thelwall, S., Sinnathamby, M.A., Aliabadi, S., Seaman, S.R., Harris, R.J., Hope, R., Lopez-Bernal, J., Gallagher, E., Charlett, A., De Angelis, D.,  Presanis, A.M. &amp; Dabrera, G.; COVID-19 Genomics UK (COG-UK) consortium (2022)  Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. <i>Lancet Infect. Dis.<\/i>, 22, 35-42.","DOI":"10.1016\/S1473-3099(21)00475-8"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Wang, Z., Zhou, J., Marshall, B., Rekaya, R., Ye, K. &amp; Liu, H.X.(2020)  SARS-CoV-2 receptor ACE2 is enriched in a subpopulation of mouse tongue epithelial cells in nongustatory papillae but not in taste buds or embryonic oral epithelium.  <i>ACS Pharmacol. Transl. Sci<\/i>., 3, 749-758.","DOI":"10.1021\/acsptsci.0c00062"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Xu, H., Zhong, L., Deng, J., Peng, J., Dan, H., Zeng, X., Li, T. &amp; Chen, Q.(2020)  High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.  <i>Int. J. Oral Sci.<\/i>, 12, 8.","DOI":"10.1038\/s41368-020-0074-x"},{"key":"18","unstructured":"Xu, X., Sun, D., Cao, M., Zhang, W., Pu, Y., Chen, C., Sun, Y., Zhou, S. &amp; Fang, B.(2022)  Analysis of clinical characteristics and prognosis of 4 264 patients with asymptomatic and mild novel coronavirus infections in Shanghai.  <i>Zhonghua Wei Zhong Bing Ji Jiu Yi Xue<\/i>, 34, 449-453."},{"key":"19","doi-asserted-by":"crossref","unstructured":"Zhang, J., Chen, N., Zhao, D., Zhang, J., Hu, Z. &amp; Tao, Z.(2022)  Clinical characteristics of COVID-19 patients infected by the omicron variant of SARS-CoV-2.  <i>Front. Med. (Lausanne)<\/i>, 9, 912367.","DOI":"10.3389\/fmed.2022.912367"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/258\/2\/258_2022.J067\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T05:44:18Z","timestamp":1662788658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/258\/2\/258_2022.J067\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.2022.j067","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"2022.J067"}}