{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:56:01Z","timestamp":1768434961540,"version":"3.49.0"},"reference-count":26,"publisher":"Tohoku University Medical Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2024]]},"DOI":"10.1620\/tjem.2023.j092","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T22:14:01Z","timestamp":1699481641000},"page":"253-261","source":"Crossref","is-referenced-by-count":4,"title":["Polo-Like Kinase 4 Correlates with Aggressive Tumor Characteristics, Shortened Disease-Free Survival and Overall Survival in Patients with Cutaneous Melanoma who Undergo Surgical Resection"],"prefix":"10.1620","volume":"262","author":[{"given":"Ling","family":"Zhang","sequence":"first","affiliation":[{"name":"Dermatology Center, Affiliated Hospital of Hebei Engineering University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Department, HanDan Central Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Han","sequence":"additional","affiliation":[{"name":"Dermatology Center, Affiliated Hospital of Hebei Engineering University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Dermatology Center, Affiliated Hospital of Hebei Engineering University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Dermatology Center, Affiliated Hospital of Hebei Engineering University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Li","sequence":"additional","affiliation":[{"name":"Dermatology Center, Affiliated Hospital of Hebei Engineering University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoying","family":"Miao","sequence":"additional","affiliation":[{"name":"Dermatology Center, Affiliated Hospital of Hebei Engineering University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Niu","sequence":"additional","affiliation":[{"name":"Dermatology Center, Affiliated Hospital of Hebei Engineering University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Ahmed, B., Qadir, M.I. &amp; Ghafoor, S. (2020)  Malignant melanoma: skin cancer-diagnosis, prevention, and treatment.  <i>Crit. Rev. Eukaryot. Gene Expr.<\/i>, 30, 291-297.","DOI":"10.1615\/CritRevEukaryotGeneExpr.2020028454"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Arnold, M., Singh, D., Laversanne, M., Vignat, J., Vaccarella, S., Meheus, F., Cust, A.E., de Vries, E., Whiteman, D.C. &amp; Bray, F. (2022)  Global burden of cutaneous melanoma in 2020 and projections to 2040.  <i>JAMA Dermatol.<\/i>, 158, 495-503.","DOI":"10.1001\/jamadermatol.2022.0160"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Bamboat, Z.M., Konstantinidis, I.T., Kuk, D., Ariyan, C.E., Brady, M.S. &amp; Coit, D.G. (2014)  Observation after a positive sentinel lymph node biopsy in patients with melanoma.  <i>Ann. Surg. Oncol.<\/i>, 21, 3117-3123.","DOI":"10.1245\/s10434-014-3758-7"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Bruce, W.J., Koljonen, J.L., Romanelli, M.R., Khan, A.U. &amp; Neumeister, M.W. (2021)  Adjuvant and neoadjuvant therapeutics for the treatment of cutaneous melanoma.  <i>Clin. Plast. Surg.<\/i>, 48, 651-658.","DOI":"10.1016\/j.cps.2021.06.001"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Buja, A., Bardin, A., Damiani, G., Zorzi, M., De Toni, C., Fusinato, R., Spina, R., Vecchiato, A., Del Fiore, P., Mocellin, S., Baldo, V., Rugge, M. &amp; Rossi, C.R. (2021)  Prognosis for cutaneous melanoma by clinical and pathological profile: a population-based study.  <i>Front. Oncol.<\/i>, 11, 737399.","DOI":"10.3389\/fonc.2021.737399"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Chen, X., Liu, X., Deng, B., Martinka, M., Zhou, Y., Lan, X. &amp; Cheng, Y. (2018)  Cytoplasmic Pin1 expression is increased in human cutaneous melanoma and predicts poor prognosis.  <i>Sci. Rep.<\/i>, 8, 16867.","DOI":"10.1038\/s41598-018-34906-6"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Denu, R.A., Shabbir, M., Nihal, M., Singh, C.K., Longley, B.J., Burkard, M.E. &amp; Ahmad, N. (2018)  Centriole overduplication is the predominant mechanism leading to centrosome amplification in melanoma.  <i>Mol. Cancer Res.<\/i>, 16, 517-527.","DOI":"10.1158\/1541-7786.MCR-17-0197"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Duan, Z., Cai, L., Cao, J. &amp; Wu, W. (2022)  Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer.  <i>Oncol. Lett.<\/i>, 24, 269.","DOI":"10.3892\/ol.2022.13389"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Hoffmann, I. (2022)  Role of polo-like kinases Plk1 and Plk4 in the initiation of centriole duplication-impact on cancer.  <i>Cells<\/i>, 11, 786.","DOI":"10.3390\/cells11050786"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Hu, C., Liu, Q., Hu, C., Wang, Y., Wang, P. &amp; Zhou, X. (2022)  PLK4 is a potential biomarker for abnormal tumor proliferation, immune infiltration, and prognosis in ccRCC.  <i>Comput. Math. Methods Med.<\/i>, 2022, 6302234.","DOI":"10.1155\/2022\/6302234"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Jang, S., Poretta, T., Bhagnani, T., Harshaw, Q., Burke, M. &amp; Rao, S. (2020)  Real-world recurrence rates and economic burden in patients with resected early-stage melanoma.  <i>Dermatol. Ther. <\/i>(<i>Heidelb<\/i>), 10, 985-999.","DOI":"10.1007\/s13555-020-00404-9"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Jiang, W., Zhao, Y., Zhang, S., Zeng, Y. &amp; Ma, J. (2022)  Aberrant expression of polo-like kinase 4 in renal cell carcinoma: association with clinicopathological characteristics and long-term survival.  <i>Oncol. Lett.<\/i>, 24, 427.","DOI":"10.3892\/ol.2022.13547"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Jiawei, W., Xiajun, B., Tian, S., Xuzheng, G. &amp; Zhenwang, Z. (2022)  Comprehensive analysis of PLKs expression and prognosis in breast cancer.  <i>Cancer Genet.<\/i>, 268-269, 83-92.","DOI":"10.1016\/j.cancergen.2022.09.007"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Kazazian, K., Go, C., Wu, H., Brashavitskaya, O., Xu, R., Dennis, J.W., Gingras, A.C. &amp; Swallow, C.J. (2017)  Plk4 promotes cancer invasion and metastasis through Arp2\/3 complex regulation of the actin cytoskeleton.  <i>Cancer Res.<\/i>, 77, 434-447.","DOI":"10.1158\/0008-5472.CAN-16-2060"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Levine, M.S., Bakker, B., Boeckx, B., Moyett, J., Lu, J., Vitre, B., Spierings, D.C., Lansdorp, P.M., Cleveland, D.W., Lambrechts, D., Foijer, F. &amp; Holland, A.J. (2017)  Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals.  <i>Dev. Cell<\/i>, 40, 313-322 e315.","DOI":"10.1016\/j.devcel.2016.12.022"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Long, G.V., Swetter, S.M., Menzies, A.M., Gershenwald, J.E. &amp; Scolyer, R.A. (2023)  Cutaneous melanoma.  <i>Lancet<\/i>, 402, 485-502.","DOI":"10.1016\/S0140-6736(23)00821-8"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Maniswami, R.R., Prashanth, S., Karanth, A.V., Koushik, S., Govindaraj, H., Mullangi, R., Rajagopal, S. &amp; Jegatheesan, S.K. (2018)  PLK4: a link between centriole biogenesis and cancer.  <i>Expert Opin. Ther. Targets<\/i>, 22, 59-73.","DOI":"10.1080\/14728222.2018.1410140"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Michielin, O., van Akkooi, A.C.J., Ascierto, P.A., Dummer, R. &amp; Keilholz, U.; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org  (2019)  Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up<i><sup>\u2020<\/sup><\/i>.  <i>Ann. Oncol.<\/i>, 30, 1884-1901.","DOI":"10.1093\/annonc\/mdz411"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Schadendorf, D., van Akkooi, A.C.J., Berking, C., Griewank, K.G., Gutzmer, R., Hauschild, A., Stang, A., Roesch, A. &amp; Ugurel, S. (2018)  Melanoma.  <i>Lancet<\/i>, 392, 971-984.","DOI":"10.1016\/S0140-6736(18)31559-9"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Statius Muller, M.G., van Leeuwen, P.A., van Diest, P.J., Pijpers, R., Nijveldt, R.J., Vuylsteke, R.J. &amp; Meijer, S. (2002)  Pattern and incidence of first site recurrences following sentinel node procedure in melanoma patients.  <i>World J. Surg.<\/i>, 26, 1405-1411.","DOI":"10.1007\/s00268-002-6197-8"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Subramanian, S., Han, G., Olson, N., Leong, S.P., Kashani-Sabet, M., White, R.L., Zager, J.S., Sondak, V.K., Messina, J.L., Pockaj, B., Kosiorek, H.E., Vetto, J., Fowler, G., Schneebaum, S. &amp; Han, D. (2021)  Regression is significantly associated with outcomes for patients with melanoma.  <i>Surgery<\/i>, 170, 1487-1494.","DOI":"10.1016\/j.surg.2021.05.010"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Tarhini, A., Ghate, S.R., Ionescu-Ittu, R., Manceur, A.M., Ndife, B., Jacques, P., Laliberte, F., Nakasato, A., Burne, R. &amp; Duh, M.S. (2018)  Postsurgical treatment landscape and economic burden of locoregional and distant recurrence in patients with operable nonmetastatic melanoma.  <i>Melanoma Res.<\/i>, 28, 618-628.","DOI":"10.1097\/CMR.0000000000000507"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Zeng, Y., Li, N., Liu, W., Zeng, M., Cheng, J. &amp; Huang, J. (2020)  Analyses of expressions and prognostic values of Polo-like kinases in non-small cell lung cancer.  <i>J. Cancer Res. Clin. Oncol.<\/i>, 146, 2447-2460.","DOI":"10.1007\/s00432-020-03288-6"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Zhang, X., Li, Z., Wei, C., Luo, L., Li, S., Zhou, J., Liang, H., Li, Y. &amp; Han, L. (2022)  PLK4 initiates crosstalk between cell cycle, cell proliferation and macrophages infiltration in gliomas.  <i>Front. Oncol.<\/i>, 12, 1055371.","DOI":"10.3389\/fonc.2022.1055371"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Zhao, Y. &amp; Wang, X. (2019)  PLK4: a promising target for cancer therapy.  <i>J. Cancer Res. Clin. Oncol.<\/i>, 145, 2413-2422.","DOI":"10.1007\/s00432-019-02994-0"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Zitouni, S., Nabais, C., Jana, S.C., Guerrero, A. &amp; Bettencourt-Dias, M. (2014)  Polo-like kinases: structural variations lead to multiple functions.  <i>Nat. Rev. Mol. Cell Biol.<\/i>, 15, 433-452.","DOI":"10.1038\/nrm3819"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/262\/4\/262_2023.J092\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T03:26:18Z","timestamp":1714188378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/262\/4\/262_2023.J092\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.2023.j092","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"2023.J092"}}