{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:12:13Z","timestamp":1716682333996},"reference-count":45,"publisher":"Tohoku University Medical Press","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tohoku J. Exp. Med."],"published-print":{"date-parts":[[2024]]},"DOI":"10.1620\/tjem.2024.j015","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T22:14:35Z","timestamp":1707948875000},"page":"43-50","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Gene-Expression Analysis of the Ligamentum Flavum of Patients with Lumbar Spinal Canal Stenosis: Comparison between the Dural and Dorsal Sides of the Thickened Ligamentum Flavum"],"prefix":"10.1620","volume":"263","author":[{"given":"Yutaka","family":"Yabe","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, National Hospital Organization Sendai Nishitaga Hospital"},{"name":"Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Takemura","sequence":"additional","affiliation":[{"name":"Nanotechnology Innovation Station, National Institute for Materials Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Hattori","sequence":"additional","affiliation":[{"name":"Nanotechnology Innovation Station, National Institute for Materials Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimi","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"622","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Altinkaya, N., Yildirim, T., Demir, S., Alkan, O. &amp; Sarica, F.B. (2011)  Factors associated with the thickness of the ligamentum flavum: is ligamentum flavum thickening due to hypertrophy or buckling? <i>Spine <\/i>(<i>Phila Pa 1976<\/i>), 36, E1093-1097.","DOI":"10.1097\/BRS.0b013e318203e2b5"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Cunliffe, I.A., Rees, R.C. &amp; Rennie, I.G. (1996)  The effect of TGF-beta 1 and TGF-beta 2 on the proliferation of human Tenon\u2019s capsule fibroblasts in tissue culture.  <i>Acta Ophthalmol. Scand.<\/i>, 74, 31-35.","DOI":"10.1111\/j.1600-0420.1996.tb00677.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Duan, Y., Ni, S., Zhao, K., Qian, J. &amp; Hu, X. (2022)  Immune cell infiltration and the genes associated with ligamentum flavum hypertrophy: identification and validation.  <i>Front. Cell Dev. Biol.<\/i>, 10, 914781.","DOI":"10.3389\/fcell.2022.914781"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Funkhouser, J.D. &amp; Aronson, N.N.Jr. (2007)  Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family.  <i>BMC Evol. Biol.<\/i>, 7, 96.","DOI":"10.1186\/1471-2148-7-96"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Gao, J., Messner, K., Ralphs, J.R. &amp; Benjamin, M. (1996)  An immunohistochemical study of enthesis development in the medial collateral ligament of the rat knee joint.  <i>Anat. Embryol. <\/i>(<i>Berl<\/i>), 194, 399-406.","DOI":"10.1007\/BF00198542"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Hayashi, F., Morimoto, M., Higashino, K., Goda, Y., Sato, N., Tezuka, F., Yamashita, K. &amp; Sairyo, K. (2022)  Myofibroblasts are increased in the dorsal layer of the hypertrophic ligamentum flavum in lumbar spinal canal stenosis.  <i>Spine J.<\/i>, 22, 697-704.","DOI":"10.1016\/j.spinee.2021.11.003"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Hjorten, R., Hansen, U., Underwood, R.A., Telfer, H.E., Fernandes, R.J., Krakow, D., Sebald, E., Wachsmann-Hogiu, S., Bruckner, P., Jacquet, R., Landis, W.J., Byers, P.H. &amp; Pace, J.M. (2007)  Type XXVII collagen at the transition of cartilage to bone during skeletogenesis.  <i>Bone<\/i>, 41, 535-542.","DOI":"10.1016\/j.bone.2007.06.024"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Honma, M., Minami-Hori, M., Takahashi, H. &amp; Iizuka, H. (2012)  Podoplanin expression in wound and hyperproliferative psoriatic epidermis: regulation by TGF-beta and STAT-3 activating cytokines, IFN-gamma, IL-6, and IL-22.  <i>J. Dermatol. Sci.<\/i>, 65, 134-140.","DOI":"10.1016\/j.jdermsci.2011.11.011"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Hur, J.W., Bae, T., Ye, S., Kim, J.H., Lee, S., Kim, K., Lee, S.H., Kim, J.S., Lee, J.B., Cho, T.H., Park, J.Y. &amp; Hur, J.K. (2017)  Myofibroblast in the ligamentum flavum hypertrophic activity.  <i>Eur. Spine J.<\/i>, 26, 2021-2030.","DOI":"10.1007\/s00586-017-4981-2"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Hur, J.W., Kim, B.J., Park, J.H., Kim, J.H., Park, Y.K., Kwon, T.H. &amp; Moon, H.J. (2015)  The mechanism of ligamentum flavum hypertrophy: introducing angiogenesis as a critical link that couples mechanical stress and hypertrophy.  <i>Neurosurgery<\/i>, 77, 274-281; discussion 281-272.","DOI":"10.1227\/NEU.0000000000000755"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Kamita, M., Mori, T., Sakai, Y., Ito, S., Gomi, M., Miyamoto, Y., Harada, A., Niida, S., Yamada, T., Watanabe, K. &amp; Ono, M. (2015)  Proteomic analysis of ligamentum flavum from patients with lumbar spinal stenosis.  <i>Proteomics<\/i>, 15, 1622-1630.","DOI":"10.1002\/pmic.201400442"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Kosaka, H., Sairyo, K., Biyani, A., Leaman, D., Yeasting, R., Higashino, K., Sakai, T., Katoh, S., Sano, T., Goel, V.K. &amp; Yasui, N. (2007)  Pathomechanism of loss of elasticity and hypertrophy of lumbar ligamentum flavum in elderly patients with lumbar spinal canal stenosis.  <i>Spine <\/i>(<i>Phila Pa 1976<\/i>), 32, 2805-2811.","DOI":"10.1097\/BRS.0b013e31815b650f"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Lakemeier, S., Schofer, M.D., Foltz, L., Schmid, R., Efe, T., Rohlfs, J., Fuchs-Winkelmann, S., El-Zayat, B.F., Paletta, J.R. &amp; Foelsch, C. (2013)  Expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and matrix metalloproteinases 1, 3, and 9 in hypertrophied ligamentum flavum.  <i>J. Spinal Disord. Tech.<\/i>, 26, 400-406.","DOI":"10.1097\/BSD.0b013e3182495b88"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Lay, A.J., Zhang, H.E., McCaughan, G.W. &amp; Gorrell, M.D. (2019)  Fibroblast activation protein in liver fibrosis.  <i>Front. Biosci. <\/i>(<i>Landmark Ed.<\/i>), 24, 1-17.","DOI":"10.2741\/4706"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Longo, G.M., Xiong, W., Greiner, T.C., Zhao, Y., Fiotti, N. &amp; Baxter, B.T. (2002)  Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms.  <i>J. Clin. Invest.<\/i>, 110, 625-632.","DOI":"10.1172\/JCI15334"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Mak, K.M., Png, C.Y. &amp; Lee, D.J. (2016)  Type V collagen in health, disease, and fibrosis.  <i>Anat. Rec. <\/i>(<i>Hoboken<\/i>), 299, 613-629.","DOI":"10.1002\/ar.23330"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Nakamura, T., Okada, T., Endo, M., Kadomatsu, T., Taniwaki, T., Sei, A., Odagiri, H., Masuda, T., Fujimoto, T., Nakamura, T., Oike, Y. &amp; Mizuta, H. (2014)  Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis.  <i>PLoS One<\/i>, 9, e85542.","DOI":"10.1371\/journal.pone.0085542"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Park, J.B., Chang, H. &amp; Lee, J.K. (2001)  Quantitative analysis of transforming growth factor-beta 1 in ligamentum flavum of lumbar spinal stenosis and disc herniation.  <i>Spine <\/i>(<i>Phila Pa 1976<\/i>), 26, E492-495.","DOI":"10.1097\/00007632-200111010-00007"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Park, J.B., Lee, J.K., Park, S.J. &amp; Riew, K.D. (2005)  Hypertrophy of ligamentum flavum in lumbar spinal stenosis associated with increased proteinase inhibitor concentration.  <i>J. Bone Joint Surg. Am.<\/i>, 87, 2750-2757.","DOI":"10.2106\/JBJS.E.00251"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Pfaffl, M.W. (2001)  A new mathematical model for relative quantification in real-time RT-PCR.  <i>Nucleic Acids Res.<\/i>, 29, e45.","DOI":"10.1093\/nar\/29.9.e45"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Sairyo, K., Biyani, A., Goel, V., Leaman, D., Booth, R. Jr., Thomas, J., Gehling, D., Vishnubhotla, L., Long, R. &amp; Ebraheim, N. (2005)  Pathomechanism of ligamentum flavum hypertrophy: a multidisciplinary investigation based on clinical, biomechanical, histologic, and biologic assessments.  <i>Spine <\/i>(<i>Phila Pa 1976<\/i>), 30, 2649-2656.","DOI":"10.1097\/01.brs.0000188117.77657.ee"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Sairyo, K., Biyani, A., Goel, V.K., Leaman, D.W., Booth, R. Jr., Thomas, J., Ebraheim, N.A., Cowgill, I.A. &amp; Mohan, S.E. (2007)  Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation-related scar tissue.  <i>Spine <\/i>(<i>Phila Pa 1976<\/i>), 32, E340-347.","DOI":"10.1097\/01.brs.0000263407.25009.6e"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Saito, T., Hara, M., Kumamaru, H., Kobayakawa, K., Yokota, K., Kijima, K., Yoshizaki, S., Harimaya, K., Matsumoto, Y., Kawaguchi, K., Hayashida, M., Inagaki, Y., Shiba, K., Nakashima, Y. &amp; Okada, S. (2017)  Macrophage infiltration is a causative factor for ligamentum flavum hypertrophy through the activation of collagen production in fibroblasts.  <i>Am. J. Pathol.<\/i>, 187, 2831-2840.","DOI":"10.1016\/j.ajpath.2017.08.020"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Sch\u00f6nstr\u00f6m, N.R. &amp; Hansson, T.H. (1991)  Thickness of the human ligamentum flavum as a function of load: an in vitro experimental study.  <i>Clin. Biomech. <\/i>(<i>Bristol, Avon<\/i>), 6, 19-24.","DOI":"10.1016\/0268-0033(91)90037-Q"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Shemesh, S., Sidon, E., Kaisler, E., Sheinis, D., Velkes, S., Ohana, N. &amp; Benayahu, D. (2018)  Diabetes mellitus is associated with increased elastin fiber loss in ligamentum flavum of patients with lumbar spinal canal stenosis: results of a pilot histological study.  <i>Eur. Spine J.<\/i>, 27, 1614-1622.","DOI":"10.1007\/s00586-017-5315-0"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Snyman, C. &amp; Niesler, C.U. (2015)  MMP-14 in skeletal muscle repair.  <i>J. Muscle Res. Cell Motil.<\/i>, 36, 215-225.","DOI":"10.1007\/s10974-015-9414-4"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Song, R.H., Tortorella, M.D., Malfait, A.M., Alston, J.T., Yang, Z., Arner, E.C. &amp; Griggs, D.W. (2007)  Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.  <i>Arthritis Rheum.<\/i>, 56, 575-585.","DOI":"10.1002\/art.22334"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Sugimoto, K., Nakamura, T., Tokunaga, T., Uehara, Y., Okada, T., Taniwaki, T., Fujimoto, T. &amp; Mizuta, H. (2018)  Matrix metalloproteinase promotes elastic fiber degradation in ligamentum flavum degeneration.  <i>PLoS One<\/i>, 13, e0200872.","DOI":"10.1371\/journal.pone.0200872"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Szpalski, M. &amp; Gunzburg, R. (2003)  Lumbar spinal stenosis in the elderly: an overview.  <i>Eur. Spine J.<\/i>, 12 Suppl 2, S170-175.","DOI":"10.1007\/s00586-003-0612-1"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Takashima, H., Takebayashi, T., Yoshimoto, M., Onodera, M., Ogon, I., Morita, T., Iesato, N., Terashima, Y., Tanimoto, K. &amp; Yamashita, T. (2018)  The difference in gender affects the pathogenesis of ligamentum flavum hypertrophy.  <i>Spine Surg. Relat. Res.<\/i>, 2, 263-269.","DOI":"10.22603\/ssrr.2017-0069"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Takeda, H., Nagai, S., Ikeda, D., Kaneko, S., Tsuji, T. &amp; Fujita, N. (2021)  Collagen profiling of ligamentum flavum in patients with lumbar spinal canal stenosis.  <i>J. Orthop. Sci.<\/i>, 26, 560-565.","DOI":"10.1016\/j.jos.2020.06.006"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Takimoto, A., Kokubu, C., Watanabe, H., Sakuma, T., Yamamoto, T., Kondoh, G., Hiraki, Y. &amp; Shukunami, C. (2019)  Differential transactivation of the upstream aggrecan enhancer regulated by PAX1\/9 depends on SOX9-driven transactivation.  <i>Sci. Rep.<\/i>, 9, 4605.","DOI":"10.1038\/s41598-019-40810-4"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Visse, R. &amp; Nagase, H. (2003)  Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.  <i>Circ. Res.<\/i>, 92, 827-839.","DOI":"10.1161\/01.RES.0000070112.80711.3D"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Weber, C.E., Li, N.Y., Wai, P.Y. &amp; Kuo, P.C. (2012)  Epithelial-mesenchymal transition, TGF-beta, and osteopontin in wound healing and tissue remodeling after injury.  <i>J. Burn Care Res.<\/i>, 33, 311-318.","DOI":"10.1097\/BCR.0b013e318240541e"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Wei, W., He, S., Wang, Z., Dong, J., Xiang, D., Li, Y., Ren, L., Kou, N. &amp; Lv, J. (2021)  LINC01534 promotes the aberrant metabolic dysfunction and inflammation in IL-1beta-simulated osteoarthritic chondrocytes by targeting miR-140-5p.  <i>Cartilage<\/i>, 13, 898S-907S.","DOI":"10.1177\/1947603519888787"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Wilgus, T.A., Vodovotz, Y., Vittadini, E., Clubbs, E.A. &amp; Oberyszyn, T.M. (2003)  Reduction of scar formation in full-thickness wounds with topical celecoxib treatment.  <i>Wound Repair Regen.<\/i>, 11, 25-34.","DOI":"10.1046\/j.1524-475X.2003.11106.x"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Yabe, Y., Hagiwara, Y., Ando, A., Tsuchiya, M., Minowa, T., Takemura, T., Honda, M., Hatori, K., Sonofuchi, K., Kanazawa, K., Koide, M., Sekiguchi, T. &amp; Itoi, E. (2015)  Chondrogenic and fibrotic process in the ligamentum flavum of patients with lumbar spinal canal stenosis.  <i>Spine <\/i>(<i>Phila Pa 1976<\/i>), 40, 429-435.","DOI":"10.1097\/BRS.0000000000000795"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Yabe, Y., Hagiwara, Y., Tsuchiya, M., Honda, M., Hatori, K., Sonofuchi, K., Kanazawa, K., Koide, M., Sekiguchi, T., Itaya, N. &amp; Itoi, E. (2016)  Decreased elastic fibers and increased proteoglycans in the ligamentum flavum of patients with lumbar spinal canal stenosis.  <i>J. Orthop. Res.<\/i>, 34, 1241-1247.","DOI":"10.1002\/jor.23130"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Yabe, Y., Hagiwara, Y., Tsuchiya, M., Onoda, Y., Yoshida, S., Onoki, T., Ishikawa, K., Kurosawa, D. &amp; Murakami, E. (2022)  Factors associated with thickening of the ligamentum flavum on magnetic resonance imaging in patients with lumbar spinal canal stenosis.  <i>Spine <\/i>(<i>Phila Pa 1976<\/i>), 47, 1036-1041.","DOI":"10.1097\/BRS.0000000000004341"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Yamayoshi, S., Yamashita, Y., Li, J., Hanagata, N., Minowa, T., Takemura, T. &amp; Koike, S. (2009)  Scavenger receptor B2 is a cellular receptor for enterovirus 71.  <i>Nat. Med.<\/i>, 15, 798-801.","DOI":"10.1038\/nm.1992"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Yang, J., Savvatis, K., Kang, J.S., Fan, P., Zhong, H., Schwartz, K., Barry, V., Mikels-Vigdal, A., Karpinski, S., Kornyeyev, D., Adamkewicz, J., Feng, X., Zhou, Q., Shang, C., Kumar, P., et al.  (2016)  Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment.  <i>Nat. Commun.<\/i>, 7, 13710.","DOI":"10.1038\/ncomms13710"},{"key":"42","doi-asserted-by":"crossref","unstructured":"Yoshida, M., Shima, K., Taniguchi, Y., Tamaki, T. &amp; Tanaka, T. (1992)  Hypertrophied ligamentum flavum in lumbar spinal canal stenosis.  Pathogenesis and morphologic and immunohistochemical observation.  <i>Spine <\/i>(<i>Phila Pa 1976<\/i>), 17, 1353-1360.","DOI":"10.1097\/00007632-199211000-00015"},{"key":"43","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Chen, J., Zhong, Z.M., Yang, D. &amp; Zhu, Q. (2010)  Is platelet-derived growth factor-BB expression proportional to fibrosis in the hypertrophied lumber ligamentum flavum? <i>Spine <\/i>(<i>Phila Pa 1976<\/i>), 35, E1479-1486.","DOI":"10.1097\/BRS.0b013e3181f3d2df"},{"key":"44","doi-asserted-by":"crossref","unstructured":"Zhong, Z.M., Zha, D.S., Xiao, W.D., Wu, S.H., Wu, Q., Zhang, Y., Liu, F.Q. &amp; Chen, J.T. (2011)  Hypertrophy of ligamentum flavum in lumbar spine stenosis associated with the increased expression of connective tissue growth factor.  <i>J. Orthop. Res.<\/i>, 29, 1592-1597.","DOI":"10.1002\/jor.21431"},{"key":"45","doi-asserted-by":"crossref","unstructured":"Zimmermann, P., Boeuf, S., Dickhut, A., Boehmer, S., Olek, S. &amp; Richter, W. (2008)  Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter.  <i>Arthritis Rheum.<\/i>, 58, 2743-2753.","DOI":"10.1002\/art.23736"}],"container-title":["The Tohoku Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/263\/1\/263_2024.J015\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T03:23:29Z","timestamp":1716607409000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tjem\/263\/1\/263_2024.J015\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1620\/tjem.2024.j015","relation":{},"ISSN":["0040-8727","1349-3329"],"issn-type":[{"value":"0040-8727","type":"print"},{"value":"1349-3329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"2024.J015"}}